Ann Oncol:《食物、营养、身体活动与癌症预防》报告再次更新(WCRF/AICR)

2017-07-25 MedSci MedSci原创

2007年,世界癌症研究基金会、美国癌症研究所的21位专家用时5年,综合了来自流行病学研究和其他研究中有关食物、营养、身体活动和肥胖程度和癌症危险性的证据,总结出《食物、营养、身体活动与癌症预防》报告。其后,专家们更新了该报告的内容,在第二份专家报告中,专家小组认为有确凿的证据表明酒精饮料和肥胖增加了食道癌的风险,而水果和蔬菜可降低其风险。该结论主要依据一个病例对照研究而得出。作为一个连续更新的报

2007年,世界癌症研究基金会、美国癌症研究所的21位专家用时5年,综合了来自流行病学研究和其他研究中有关食物、营养、身体活动和肥胖程度和癌症危险性的证据,总结出《食物、营养、身体活动与癌症预防》报告。其后,专家们更新了该报告的内容,在第二份专家报告中,专家小组认为有确凿的证据表明酒精饮料和肥胖增加了食道癌的风险,而水果和蔬菜可降低其风险。该结论主要依据一个病例对照研究而得出。作为一个连续更新的报告,近日,研究人员通过队列研究中积累的科学证据对该报告再次进行了更新。

方法:研究人员通过对2017年1月10日之前的PubMed数据库的搜索,更新了该连续更新报告的数据库,并进行了剂量反应分析,用随机效应模型估计总结性相对危险度(RR)和95%置信区间(CI)。

本研究共纳入了13项荟萃分析,即57项队列研究。食管腺癌的风险与蔬菜的摄入量呈负相关(每100?克/天的RR:0.89;95%置信区间:0.80-0.99,n = 3),与体重指数(BMI)直接相关(每5kg/平方米的RR:1.47;95%置信区间:1.34-1.61,n = 9)。食管鳞状细胞癌,与水果的摄入量(每增加100g/天的RR:0.84;95%置信区间:0.75-0.94,n = 3)和BMI(每增加5kg/平方米的RR:0.64;95%置信区间:0.56-0.73,n = 8)负相关,和处理过的肉类的摄入量(每50?克/天的RR 递增:1.59;95%置信区间:1.11-2.28,n = 3),加工肉和红肉的摄入量(每100?克/天的RR递增:1.37;95%置信区间:1.04-1.82,n = 3)和酒精的摄入量(每10?克/天的RR 增量:1.25;95%CI:1.12-1.41,n = 6)直接相关。

结论:队列研究的证据表明,蔬菜和体重控制在食管腺癌的发展中具有保护作用。对于鳞状细胞癌,摄入较多的红肉和加工过的肉类,以及酒精可能会增加患病风险,而水果摄入可能起到保护作用。

原始出处:

Vingeliene S, Chan DSM,et al.An update of the WCRF/AICR systematic literature review and meta-analysis on dietary and anthropometric factors and esophageal cancer risk.Ann Oncol. 2017 Jun 29. doi: 10.1093/annonc/mdx338. [Epub ahead of print]

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    2018-02-12 仁心济世
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    2018-07-03 minlingfeng
  3. 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    2017-07-28 1e145228m78(暂无匿称)

    学习了,谢谢作者分享!

    0

  4. 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    2017-07-27 1e145228m78(暂无匿称)

    学习了,谢谢作者分享!

    0

  5. 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    2017-07-27 yhy100201
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    2017-07-25 1e145228m78(暂无匿称)

    学习了,谢谢作者分享!

    0

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    2017-07-25 童小孩

    学习

    0

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