PNAS：重磅！攻破三阴性乳腺癌！梅奥诊所发现新药物疗法！

2018-10-11 Michael,Zoe 转化医学网

根据最新2018全球肿瘤分析报告，女性死亡率最高的肿瘤仍是多年的“榜首”——乳腺癌，而在乳腺癌中对于化疗和放疗均不敏感的三阴性乳腺癌在所有乳腺癌类型中其致死率最高。虽然对于该类型乳腺癌的突破性研究频频出现，但最终应用于临床研究的却屈指可数。而来自明尼苏达州梅奥诊所的分子生物学家John Hawse教授率领的研究团队发现已经应用于临床的雌二醇药物可用于治疗三阴性乳腺癌。研究人员很快会在II期临床试验

导读

根据最新2018全球肿瘤分析报告，女性死亡率最高的肿瘤仍是多年的“榜首”——乳腺癌，而在乳腺癌中对于化疗和放疗均不敏感的三阴性乳腺癌在所有乳腺癌类型中其致死率最高。虽然对于该类型乳腺癌的突破性研究频频出现，但最终应用于临床研究的却屈指可数。而来自明尼苏达州梅奥诊所的分子生物学家John Hawse教授率领的研究团队发现已经应用于临床的雌二醇药物可用于治疗三阴性乳腺癌。研究人员很快会在II期临床试验中测试这种具有令人意想不到用途的药物。其研究的最新结果发表于最新的《PNAS》杂志。

与其他类型的乳腺癌相比，三阴性乳腺癌能够更快地增殖和转移。此外，由于该类型的癌细胞缺乏激素受体，导致临床常用的激素疗法对该类型肿瘤的治疗无效。因此。对该类型的肿瘤目前唯一治疗方法是化疗，但其对患者的生活质量影响较大。

雌二醇与雌激素β受体

Hawse教授解释道，“三阴性乳腺癌是一种缺乏雌激素受体α、孕激素受体和（HER2）表达的乳腺癌，由于其缺乏有效的靶点，因此表现出较高的转移率和复发率”。

然而，Hawse和其团队先前的研究发现，另外一种形式的雌激素受体——被称为雌激素受体β存在于25％的三阴性肿瘤中，以及超过30％的雌激素受体阳性的乳腺癌肿瘤当中。

该研究还表明，雌激素受体β是一种肿瘤抑制因子，与患者更好的预后密切相关。在他们的新研究中，Hawse和他的同事们研究了雌二醇对表达雌激素受体β的三阴性肿瘤的影响。

Hawse表示，“他们发现雌二醇通常情况下可以刺激表达雌激素受体α的癌细胞的生长，但在三阴性乳腺癌中却具有相反的效果。当仅有雌激素受体β存在时，雌二醇可抑制三阴性乳腺癌的生长”。

雌二醇诱导半胱氨酸蛋白酶的产生

这项新研究阐明了雌二醇与三阴性乳腺癌相互作用的分子机制。当雌二醇与雌激素受体β结合时，它会诱导出一个被称为“半胱氨酸蛋白酶”物质的分泌。

而诱导出的蛋白酶则会抑制肿瘤生长并阻止癌细胞扩散。这表明雌激素受体β靶向疗法或可成为一种全新的三阴性乳腺癌治疗方案，其可靶向治疗雌激素受体β 表达的三阴性乳腺癌患者。

在不久的将来，研究人员计划开始一项II期临床试验，进而更为详细地测试雌二醇在治疗雌激素受体β阳性癌症中的有效性。

医学肿瘤学家Matthew Goetz博士称，“雌二醇目前被FDA批准用于乳腺癌患者的治疗，但其仅限于雌激素受体α阳性乳腺癌患者，目前此类患者已经对现有标准疗法产生抗药性。

因此，他们急需加强雌二醇在乳腺癌患者的应用研究”。他对雌二醇重新应用于雌激素受体β表达阳性三阴性乳腺癌的治疗充满信心。

原始出处;

Jordan M. Reese, Elizabeth S. Bruinsma, Adam W. Nelson, et.al. ERβ-mediated induction of cystatins results in suppression of TGFβ signaling and inhibition of triple-negative breast cancer metastasis. PNAS October 9, 2018 115 (41) E9580-E9589

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2018-11-16 gostraight

#药物疗法#

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2019-01-12 ms1065684921169360

#新药物#

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encodeId=79d61458e161d, content=<a href='/topic/show?id=3ef91982030' target=_blank style='color:#2F92EE;'>#三阴性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=19820, encryptionId=3ef91982030, topicName=三阴性)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a5666112721, createdName=xlysu, createdTime=Sat Oct 13 11:27:00 CST 2018, time=2018-10-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1489731, encodeId=baed1489e310a, content=<a href='/topic/show?id=39dd6242530' target=_blank style='color:#2F92EE;'>#梅奥诊所#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=62425, encryptionId=39dd6242530, topicName=梅奥诊所)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=22488584370, createdName=echonoir, createdTime=Sat Oct 13 11:27:00 CST 2018, time=2018-10-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1549389, encodeId=5af315493893f, content=<a href='/topic/show?id=f7879600061' target=_blank style='color:#2F92EE;'>#重磅#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=96000, encryptionId=f7879600061, topicName=重磅)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=3acc14121561, createdName=xxxx1054, createdTime=Sat Oct 13 11:27:00 CST 2018, time=2018-10-13, status=1, ipAttribution=)]
2018-10-28 circumcision

#阴性乳腺癌#

28 0
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style='color:#2F92EE;'>#PNAS#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=21, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=14428, encryptionId=f32014428fc, topicName=PNAS)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=395f25, createdName=爆笑小医, createdTime=Sat Nov 17 19:27:00 CST 2018, time=2018-11-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=349205, encodeId=0e24349205c5, content=优秀啊！, beContent=null, objectType=article, channel=null, level=null, likeNumber=72, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1c961986924, createdName=1e196c88m23(暂无匿称), createdTime=Sat Oct 13 20:36:21 CST 2018, time=2018-10-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1311131, encodeId=87a113111312b, content=<a href='/topic/show?id=39be91564e5' target=_blank style='color:#2F92EE;'>#诊所#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=91564, encryptionId=39be91564e5, topicName=诊所)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c805395, createdName=ycmayy, createdTime=Sat Oct 13 11:27:00 CST 2018, time=2018-10-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1368288, encodeId=aff2136828814, content=<a href='/topic/show?id=8a5e6242257' target=_blank style='color:#2F92EE;'>#梅奥#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=62422, encryptionId=8a5e6242257, topicName=梅奥)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c689267, createdName=cmj8wellington, createdTime=Sat Oct 13 11:27:00 CST 2018, time=2018-10-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1458716, encodeId=79d61458e161d, content=<a href='/topic/show?id=3ef91982030' target=_blank style='color:#2F92EE;'>#三阴性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=19820, encryptionId=3ef91982030, topicName=三阴性)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a5666112721, createdName=xlysu, createdTime=Sat Oct 13 11:27:00 CST 2018, time=2018-10-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1489731, encodeId=baed1489e310a, content=<a href='/topic/show?id=39dd6242530' target=_blank style='color:#2F92EE;'>#梅奥诊所#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=62425, encryptionId=39dd6242530, topicName=梅奥诊所)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=22488584370, createdName=echonoir, createdTime=Sat Oct 13 11:27:00 CST 2018, time=2018-10-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1549389, encodeId=5af315493893f, content=<a href='/topic/show?id=f7879600061' target=_blank style='color:#2F92EE;'>#重磅#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=96000, encryptionId=f7879600061, topicName=重磅)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=3acc14121561, createdName=xxxx1054, createdTime=Sat Oct 13 11:27:00 CST 2018, time=2018-10-13, status=1, ipAttribution=)]
2018-11-17 爆笑小医

#PNAS#

21 0
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style='color:#2F92EE;'>#PNAS#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=21, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=14428, encryptionId=f32014428fc, topicName=PNAS)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=395f25, createdName=爆笑小医, createdTime=Sat Nov 17 19:27:00 CST 2018, time=2018-11-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=349205, encodeId=0e24349205c5, content=优秀啊！, beContent=null, objectType=article, channel=null, level=null, likeNumber=72, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1c961986924, createdName=1e196c88m23(暂无匿称), createdTime=Sat Oct 13 20:36:21 CST 2018, time=2018-10-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1311131, encodeId=87a113111312b, content=<a href='/topic/show?id=39be91564e5' target=_blank style='color:#2F92EE;'>#诊所#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=91564, encryptionId=39be91564e5, topicName=诊所)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c805395, createdName=ycmayy, createdTime=Sat Oct 13 11:27:00 CST 2018, time=2018-10-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1368288, encodeId=aff2136828814, content=<a href='/topic/show?id=8a5e6242257' target=_blank style='color:#2F92EE;'>#梅奥#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=62422, encryptionId=8a5e6242257, topicName=梅奥)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c689267, createdName=cmj8wellington, createdTime=Sat Oct 13 11:27:00 CST 2018, time=2018-10-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1458716, encodeId=79d61458e161d, content=<a href='/topic/show?id=3ef91982030' target=_blank style='color:#2F92EE;'>#三阴性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=19820, encryptionId=3ef91982030, topicName=三阴性)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a5666112721, createdName=xlysu, createdTime=Sat Oct 13 11:27:00 CST 2018, time=2018-10-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1489731, encodeId=baed1489e310a, content=<a href='/topic/show?id=39dd6242530' target=_blank style='color:#2F92EE;'>#梅奥诊所#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=62425, encryptionId=39dd6242530, topicName=梅奥诊所)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=22488584370, createdName=echonoir, createdTime=Sat Oct 13 11:27:00 CST 2018, time=2018-10-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1549389, encodeId=5af315493893f, content=<a href='/topic/show?id=f7879600061' target=_blank style='color:#2F92EE;'>#重磅#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=96000, encryptionId=f7879600061, topicName=重磅)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=3acc14121561, createdName=xxxx1054, createdTime=Sat Oct 13 11:27:00 CST 2018, time=2018-10-13, status=1, ipAttribution=)]
2018-10-13 1e196c88m23(暂无匿称)

优秀啊！

72 0
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style='color:#2F92EE;'>#PNAS#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=21, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=14428, encryptionId=f32014428fc, topicName=PNAS)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=395f25, createdName=爆笑小医, createdTime=Sat Nov 17 19:27:00 CST 2018, time=2018-11-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=349205, encodeId=0e24349205c5, content=优秀啊！, beContent=null, objectType=article, channel=null, level=null, likeNumber=72, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1c961986924, createdName=1e196c88m23(暂无匿称), createdTime=Sat Oct 13 20:36:21 CST 2018, time=2018-10-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1311131, encodeId=87a113111312b, content=<a href='/topic/show?id=39be91564e5' target=_blank style='color:#2F92EE;'>#诊所#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=91564, encryptionId=39be91564e5, topicName=诊所)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c805395, createdName=ycmayy, createdTime=Sat Oct 13 11:27:00 CST 2018, time=2018-10-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1368288, encodeId=aff2136828814, content=<a href='/topic/show?id=8a5e6242257' target=_blank style='color:#2F92EE;'>#梅奥#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=62422, encryptionId=8a5e6242257, topicName=梅奥)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c689267, createdName=cmj8wellington, createdTime=Sat Oct 13 11:27:00 CST 2018, time=2018-10-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1458716, encodeId=79d61458e161d, content=<a href='/topic/show?id=3ef91982030' target=_blank style='color:#2F92EE;'>#三阴性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=19820, encryptionId=3ef91982030, topicName=三阴性)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a5666112721, createdName=xlysu, createdTime=Sat Oct 13 11:27:00 CST 2018, time=2018-10-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1489731, encodeId=baed1489e310a, content=<a href='/topic/show?id=39dd6242530' target=_blank style='color:#2F92EE;'>#梅奥诊所#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=62425, encryptionId=39dd6242530, topicName=梅奥诊所)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=22488584370, createdName=echonoir, createdTime=Sat Oct 13 11:27:00 CST 2018, time=2018-10-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1549389, encodeId=5af315493893f, content=<a href='/topic/show?id=f7879600061' target=_blank style='color:#2F92EE;'>#重磅#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=96000, encryptionId=f7879600061, topicName=重磅)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=3acc14121561, createdName=xxxx1054, createdTime=Sat Oct 13 11:27:00 CST 2018, time=2018-10-13, status=1, ipAttribution=)]
2018-10-13 ycmayy

#诊所#

27 0
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createdAvatar=https://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTIuNQXObUwZmFG3VcZa2uhFq27sY7vfTowUhQCgRj2bj1odUibMF4sFXpuRLf6IE5t5yGVDSiaOoOcQ/132, createdBy=1e622500088, createdName=ms1065684921169360, createdTime=Sat Jan 12 01:27:00 CST 2019, time=2019-01-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2047995, encodeId=cfb4204e99536, content=<a href='/topic/show?id=12e49e53102' target=_blank style='color:#2F92EE;'>#阴性乳腺癌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=97531, encryptionId=12e49e53102, topicName=阴性乳腺癌)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f65b226, createdName=circumcision, createdTime=Sun Oct 28 03:27:00 CST 2018, time=2018-10-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1856226, encodeId=6b121856226e3, content=<a href='/topic/show?id=f32014428fc' target=_blank style='color:#2F92EE;'>#PNAS#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=21, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=14428, encryptionId=f32014428fc, topicName=PNAS)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=395f25, createdName=爆笑小医, createdTime=Sat Nov 17 19:27:00 CST 2018, time=2018-11-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=349205, encodeId=0e24349205c5, content=优秀啊！, beContent=null, objectType=article, channel=null, level=null, likeNumber=72, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1c961986924, createdName=1e196c88m23(暂无匿称), createdTime=Sat Oct 13 20:36:21 CST 2018, time=2018-10-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1311131, encodeId=87a113111312b, content=<a href='/topic/show?id=39be91564e5' target=_blank style='color:#2F92EE;'>#诊所#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=91564, encryptionId=39be91564e5, topicName=诊所)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c805395, createdName=ycmayy, createdTime=Sat Oct 13 11:27:00 CST 2018, time=2018-10-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1368288, encodeId=aff2136828814, content=<a href='/topic/show?id=8a5e6242257' target=_blank style='color:#2F92EE;'>#梅奥#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=62422, encryptionId=8a5e6242257, topicName=梅奥)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c689267, createdName=cmj8wellington, createdTime=Sat Oct 13 11:27:00 CST 2018, time=2018-10-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1458716, encodeId=79d61458e161d, content=<a href='/topic/show?id=3ef91982030' target=_blank style='color:#2F92EE;'>#三阴性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=19820, encryptionId=3ef91982030, topicName=三阴性)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a5666112721, createdName=xlysu, createdTime=Sat Oct 13 11:27:00 CST 2018, time=2018-10-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1489731, encodeId=baed1489e310a, content=<a href='/topic/show?id=39dd6242530' target=_blank style='color:#2F92EE;'>#梅奥诊所#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=62425, encryptionId=39dd6242530, topicName=梅奥诊所)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=22488584370, createdName=echonoir, createdTime=Sat Oct 13 11:27:00 CST 2018, time=2018-10-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1549389, encodeId=5af315493893f, content=<a href='/topic/show?id=f7879600061' target=_blank style='color:#2F92EE;'>#重磅#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=96000, encryptionId=f7879600061, topicName=重磅)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=3acc14121561, createdName=xxxx1054, createdTime=Sat Oct 13 11:27:00 CST 2018, time=2018-10-13, status=1, ipAttribution=)]
2018-10-13 cmj8wellington

#梅奥#

51 0
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style='color:#2F92EE;'>#PNAS#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=21, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=14428, encryptionId=f32014428fc, topicName=PNAS)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=395f25, createdName=爆笑小医, createdTime=Sat Nov 17 19:27:00 CST 2018, time=2018-11-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=349205, encodeId=0e24349205c5, content=优秀啊！, beContent=null, objectType=article, channel=null, level=null, likeNumber=72, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1c961986924, createdName=1e196c88m23(暂无匿称), createdTime=Sat Oct 13 20:36:21 CST 2018, time=2018-10-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1311131, encodeId=87a113111312b, content=<a href='/topic/show?id=39be91564e5' target=_blank style='color:#2F92EE;'>#诊所#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=91564, encryptionId=39be91564e5, topicName=诊所)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c805395, createdName=ycmayy, createdTime=Sat Oct 13 11:27:00 CST 2018, time=2018-10-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1368288, encodeId=aff2136828814, content=<a href='/topic/show?id=8a5e6242257' target=_blank style='color:#2F92EE;'>#梅奥#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=62422, encryptionId=8a5e6242257, topicName=梅奥)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c689267, createdName=cmj8wellington, createdTime=Sat Oct 13 11:27:00 CST 2018, time=2018-10-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1458716, encodeId=79d61458e161d, content=<a href='/topic/show?id=3ef91982030' target=_blank style='color:#2F92EE;'>#三阴性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=19820, encryptionId=3ef91982030, topicName=三阴性)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a5666112721, createdName=xlysu, createdTime=Sat Oct 13 11:27:00 CST 2018, time=2018-10-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1489731, encodeId=baed1489e310a, content=<a href='/topic/show?id=39dd6242530' target=_blank style='color:#2F92EE;'>#梅奥诊所#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=62425, encryptionId=39dd6242530, topicName=梅奥诊所)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=22488584370, createdName=echonoir, createdTime=Sat Oct 13 11:27:00 CST 2018, time=2018-10-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1549389, encodeId=5af315493893f, content=<a href='/topic/show?id=f7879600061' target=_blank style='color:#2F92EE;'>#重磅#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=96000, encryptionId=f7879600061, topicName=重磅)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=3acc14121561, createdName=xxxx1054, createdTime=Sat Oct 13 11:27:00 CST 2018, time=2018-10-13, status=1, ipAttribution=)]
2018-10-13 xlysu

#三阴性#

30 0
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createdAvatar=https://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTIuNQXObUwZmFG3VcZa2uhFq27sY7vfTowUhQCgRj2bj1odUibMF4sFXpuRLf6IE5t5yGVDSiaOoOcQ/132, createdBy=1e622500088, createdName=ms1065684921169360, createdTime=Sat Jan 12 01:27:00 CST 2019, time=2019-01-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2047995, encodeId=cfb4204e99536, content=<a href='/topic/show?id=12e49e53102' target=_blank style='color:#2F92EE;'>#阴性乳腺癌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=97531, encryptionId=12e49e53102, topicName=阴性乳腺癌)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f65b226, createdName=circumcision, createdTime=Sun Oct 28 03:27:00 CST 2018, time=2018-10-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1856226, encodeId=6b121856226e3, content=<a href='/topic/show?id=f32014428fc' target=_blank style='color:#2F92EE;'>#PNAS#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=21, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=14428, encryptionId=f32014428fc, topicName=PNAS)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=395f25, createdName=爆笑小医, createdTime=Sat Nov 17 19:27:00 CST 2018, time=2018-11-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=349205, encodeId=0e24349205c5, content=优秀啊！, beContent=null, objectType=article, channel=null, level=null, likeNumber=72, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1c961986924, createdName=1e196c88m23(暂无匿称), createdTime=Sat Oct 13 20:36:21 CST 2018, time=2018-10-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1311131, encodeId=87a113111312b, content=<a href='/topic/show?id=39be91564e5' target=_blank style='color:#2F92EE;'>#诊所#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=91564, encryptionId=39be91564e5, topicName=诊所)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c805395, createdName=ycmayy, createdTime=Sat Oct 13 11:27:00 CST 2018, time=2018-10-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1368288, encodeId=aff2136828814, content=<a href='/topic/show?id=8a5e6242257' target=_blank style='color:#2F92EE;'>#梅奥#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=62422, encryptionId=8a5e6242257, topicName=梅奥)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c689267, createdName=cmj8wellington, createdTime=Sat Oct 13 11:27:00 CST 2018, time=2018-10-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1458716, encodeId=79d61458e161d, content=<a href='/topic/show?id=3ef91982030' target=_blank style='color:#2F92EE;'>#三阴性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=19820, encryptionId=3ef91982030, topicName=三阴性)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a5666112721, createdName=xlysu, createdTime=Sat Oct 13 11:27:00 CST 2018, time=2018-10-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1489731, encodeId=baed1489e310a, content=<a href='/topic/show?id=39dd6242530' target=_blank style='color:#2F92EE;'>#梅奥诊所#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=62425, encryptionId=39dd6242530, topicName=梅奥诊所)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=22488584370, createdName=echonoir, createdTime=Sat Oct 13 11:27:00 CST 2018, time=2018-10-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1549389, encodeId=5af315493893f, content=<a href='/topic/show?id=f7879600061' target=_blank style='color:#2F92EE;'>#重磅#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=96000, encryptionId=f7879600061, topicName=重磅)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=3acc14121561, createdName=xxxx1054, createdTime=Sat Oct 13 11:27:00 CST 2018, time=2018-10-13, status=1, ipAttribution=)]
2018-10-13 echonoir

#梅奥诊所#

25 0
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style='color:#2F92EE;'>#PNAS#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=21, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=14428, encryptionId=f32014428fc, topicName=PNAS)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=395f25, createdName=爆笑小医, createdTime=Sat Nov 17 19:27:00 CST 2018, time=2018-11-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=349205, encodeId=0e24349205c5, content=优秀啊！, beContent=null, objectType=article, channel=null, level=null, likeNumber=72, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1c961986924, createdName=1e196c88m23(暂无匿称), createdTime=Sat Oct 13 20:36:21 CST 2018, time=2018-10-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1311131, encodeId=87a113111312b, content=<a href='/topic/show?id=39be91564e5' target=_blank style='color:#2F92EE;'>#诊所#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=91564, encryptionId=39be91564e5, topicName=诊所)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c805395, createdName=ycmayy, createdTime=Sat Oct 13 11:27:00 CST 2018, time=2018-10-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1368288, encodeId=aff2136828814, content=<a href='/topic/show?id=8a5e6242257' target=_blank style='color:#2F92EE;'>#梅奥#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=62422, encryptionId=8a5e6242257, topicName=梅奥)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c689267, createdName=cmj8wellington, createdTime=Sat Oct 13 11:27:00 CST 2018, time=2018-10-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1458716, encodeId=79d61458e161d, content=<a href='/topic/show?id=3ef91982030' target=_blank style='color:#2F92EE;'>#三阴性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=19820, encryptionId=3ef91982030, topicName=三阴性)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a5666112721, createdName=xlysu, createdTime=Sat Oct 13 11:27:00 CST 2018, time=2018-10-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1489731, encodeId=baed1489e310a, content=<a href='/topic/show?id=39dd6242530' target=_blank style='color:#2F92EE;'>#梅奥诊所#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=62425, encryptionId=39dd6242530, topicName=梅奥诊所)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=22488584370, createdName=echonoir, createdTime=Sat Oct 13 11:27:00 CST 2018, time=2018-10-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1549389, encodeId=5af315493893f, content=<a href='/topic/show?id=f7879600061' target=_blank style='color:#2F92EE;'>#重磅#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=96000, encryptionId=f7879600061, topicName=重磅)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=3acc14121561, createdName=xxxx1054, createdTime=Sat Oct 13 11:27:00 CST 2018, time=2018-10-13, status=1, ipAttribution=)]
2018-10-13 xxxx1054

#重磅#

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PNAS：重磅！攻破三阴性乳腺癌！梅奥诊所发现新药物疗法！

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