JACC:心肌梗死患者白细胞介素1β水平与过早死亡风险之间的关系

2020-08-29 MedSci原创 MedSci原创

急性心肌梗死患者入院时测量的IL-1β与死亡风险和复发性MACE独立相关。

在既往有心肌梗死(MI)和高敏C反应蛋白(hs-CRP)升高的患者中,抑制白介素1β(IL-1β)固有免疫途径具有抗炎效应,并与降低复发性血管事件风险相关。近日,心血管领域权威杂志JACC上发表了一篇研究文章,该研究旨在评估接受经皮冠状动脉介入治疗的急性ST段抬高型心肌梗死(MI)患者IL-1β水平与全因死亡率之间的关系,以及IL-1β和hs-CRP浓度与过早死亡风险之间的相互作用。

研究人员对前瞻性队列研究中1398名ST段抬高的MI患者进行了IL-1β检测,并使用多元Cox比例回归分析法分析了90天和一年内全因和心血管疾病死亡率的风险比。研究人员分析了主要心血管事件(MACE)。

入院时测量的IL-1β浓度与90天全因死亡率相关(每升高1个SD调整后的风险比[adjHR]为1.47;95%CI为1.16至1.87;p<0.002)。这种关系是非线性的,并且IL-1β水平处于最高三分位数与90天(adjHR为2.78; 95%CI为1.61-4.79,p=0.0002)和一年(adjHR为1.93; 95%CI为1.21-3.06,p=0.005))的较高死亡率相关,而与hs-CRP浓度无关。在考虑90天(分别有adjHR:2.42;95%CI为1.36-4.28,p=0.002和2.29;95%CI为1.31-4.01,p=0.004)和1年(分别有adjHR:2.32; 95%CI为1.36-3.97,p=0.002和2.35;95%CI:1.39-3.96,p=0.001)心血管死亡和MACE,均观察到显著关系。

由此可见,急性心肌梗死患者入院时测量的IL-1β与死亡风险和复发性MACE独立相关。

原始出处:

Johanne Silvain,et al.Interleukin-1Beta and Risk of Premature Death in Patients with Myocardial Infarction.JACC.2020.https://www.onlinejacc.org/content/early/recent

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    2020-08-29 lovetcm

    #心肌梗死#急性心肌梗死患者入院时测量的IL-1β与死亡风险和复发性MACE独立相关

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