Rheumatology:嗜酸性肉芽肿伴多血管炎(EGPA)亚临床动脉粥样硬化的证据

2022-07-25 紫菀款冬 MedSci原创

评估嗜酸性肉芽肿性多血管炎(EGPA)患者和对照人群中的亚临床动脉粥样硬化。

目的:与普通人群相比,受嗜酸性肉芽肿性多血管炎(EGPA)影响的患者发生动脉粥样硬化血栓事件的风险增加。在其他抗中性粒细胞胞浆抗体(ANCA)相关血管炎(AAV)中观察到动脉粥样硬化亚临床标记物的频率增加,但没有专门针对EGPA的研究。因此,该研究评估了EGPA患者和对照人群中的亚临床动脉粥样硬化。

方法:40例EGPA患者和80例对照组(按年龄、性别和传统心血管危险因素匹配)接受了颈总动脉(CCA)内膜-中层厚度(IMT)超声评估。还研究了CCA斑块的存在。并且评估了CCA-IMT与临床、实验室特征之间的相关性

结果:EGPA患者的CCA-IMT中位数显著高于对照组(p=0.002)。此外,EGPA患者中CCA-IMT增加和斑块出现的受试者比例显著较高(两者均p<0.001)。此外,在EGPA队列中,CCA-IMT往往随着疾病持续时间(p=0.034)和皮质类固醇累积剂量(p=0.004)而增加。

未发现CCA-IMT、ANCA状态、其他临床特征和治疗方案之间存在显著相关性。值得注意的是,在有、无CCA-IMT增加的患者中,传统心血管危险因素的患病率具有可比性

结论:与对照组相比,EGPA患者亚临床动脉粥样硬化的超声标记物增加,与传统的心血管危险因素无关

 

文献来源:

Bello F, Bettiol A, Silvestri E, et al. Evidence of subclinical atherosclerosis in Eosinophilic Granulomatosis with Polyangiitis (EGPA) [published online ahead of print, 2022 Jul 21]. Rheumatology (Oxford). 2022;keac427. doi:10.1093/rheumatology/keac427

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    2022-07-22 jingjing

    大家一般关心疾病,但是亚临床更重要,这是疾病防控方向的前移,各类疾病都是这样。如亚临床甲减,亚临床心肌损伤,亚临床心衰等

    0

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