J Gastroenterology:肿瘤部位对III期结肠癌淋巴结数量的影响与预后的关系

2019-01-06 MedSci MedSci原创

目前文献对结肠癌患者肠系膜淋巴结比(LNR)的预后意义的定义并不一致。本项研究的目的是确定右侧和左侧结肠癌中LNR的适当临界值,并阐明其临床意义。

背景及目的
目前文献对结肠癌患者肠系膜淋巴结比(LNR)的预后意义的定义并不一致。本项研究的目的是确定右侧和左侧结肠癌中LNR的适当临界值,并阐明其临床意义。

方法
研究人员收集5463例III期结肠癌患者的临床病理资料。以左右结肠癌患者的预后为指标,对LNR的最佳截止值进行了研究。同时使用Akaike信息标准(AIC)比较了LNR与淋巴结转移数量之间的预后影响,并评估了LNR在每个III期亚类中的预后意义。

结果
当LNR分别按右侧和左侧结肠癌的截止值0.16和0.22分类时,表现出最佳表现。LNR-低位结肠癌患者要比LNR-高位结肠癌患者在IIIA期(95.7%对89.3%),IIIB(86.7%对77.2%)和IIIC(71.2%对58.7%)中有更好的癌症特异性存活率。

结论
本项研究的结果证明右侧和左侧结肠癌之间LNR的适当截止值的差异。通过LNR的位置特异性截断分类可能对III期癌症患者的危险分层有用。

原始出处:

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    2019-12-14 juliusluan78
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    2019-05-23 许安
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    2019-01-08 sodoo
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