Metabolites:耳蜗移植患者外淋巴代谢组学与听力损失持续时间的关系研究

2019-11-19 Alex Yang MedSci原创

外淋巴代谢组学是改善人们对感觉神经性耳聋病理生理认识的一种新兴的创新方法。最近,有研究人员对人类外淋巴进行了代谢组学分析来评估代谢组与听力损失持续时间之间的关系。研究参与者的入选标准为符合耳蜗移植并在手术期间容易接近卵圆窗,排除了那些进行移植的耳蜗具有残余声学听力的患者。研究人员在耳蜗移植手术期间对19名受试者进行了外淋巴样本采集并对其进行了分析。研究人员共鉴定了106种不同的代谢物。研究发现,代

外淋巴代谢组学是改善人们对感觉神经性耳聋病理生理认识的一种新兴的创新方法。最近,有研究人员对人类外淋巴进行了代谢组学分析来评估代谢组与听力损失持续时间之间的关系。

研究参与者的入选标准为符合耳蜗移植并在手术期间容易接近卵圆窗,排除了那些进行移植的耳蜗具有残余声学听力的患者。研究人员在耳蜗移植手术期间对19名受试者进行了外淋巴样本采集并对其进行了分析。研究人员共鉴定了106种不同的代谢物。研究发现,代谢物情况在≤12年听力损失和>12年听力损失的患者中显著不同,其中包括了以下化合物:n -乙酰神经氨酸、戊二酸、胱氨酸、2-甲基丙酸、丁酸和黄嘌呤。和预期相似,患者的年龄也是一个主要的区别参数。研究人员观察了不同听力损失持续时间的代谢特征。

最后,研究人员指出,他们的发现对阐释感觉神经性耳聋发病机制相关的病理生理途径具有重要意义,并为使用代谢组分析进一步探索感觉神经性耳聋机制提供了可能。

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    2020-06-30 guojianrong
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    2020-03-03 一闲
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    2019-11-21 ysjykql
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  5. [GetPortalCommentsPageByObjectIdResponse(id=1888090, encodeId=ebac1888090e1, content=<a href='/topic/show?id=d56611584ec' target=_blank style='color:#2F92EE;'>#Meta#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11584, encryptionId=d56611584ec, topicName=Meta)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d8f4110, createdName=guojianrong, createdTime=Tue Jun 30 23:12:00 CST 2020, time=2020-06-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1896580, encodeId=94b1189658032, content=<a href='/topic/show?id=4a391158248' target=_blank style='color:#2F92EE;'>#MET#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11582, encryptionId=4a391158248, topicName=MET)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=18fc139, createdName=一闲, createdTime=Tue Mar 03 06:12:00 CST 2020, time=2020-03-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1306447, encodeId=c1ec130644e5f, content=<a href='/topic/show?id=aeb639230b7' target=_blank style='color:#2F92EE;'>#听力#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=39230, encryptionId=aeb639230b7, topicName=听力)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=96d4340, createdName=ysjykql, createdTime=Thu Nov 21 04:12:00 CST 2019, time=2019-11-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1378953, encodeId=0cb813e895310, content=<a href='/topic/show?id=db548051642' target=_blank style='color:#2F92EE;'>#耳蜗移植#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=80516, encryptionId=db548051642, topicName=耳蜗移植)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=ba58436, createdName=马龙, createdTime=Thu Nov 21 04:12:00 CST 2019, time=2019-11-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1480303, encodeId=f217148030339, content=<a href='/topic/show?id=2f6f2546977' target=_blank style='color:#2F92EE;'>#代谢组#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=25469, encryptionId=2f6f2546977, topicName=代谢组)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0f1e7632392, createdName=ms6897892027066920, createdTime=Thu Nov 21 04:12:00 CST 2019, time=2019-11-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1503669, encodeId=18271503669dd, content=<a href='/topic/show?id=4f215634296' target=_blank style='color:#2F92EE;'>#持续时间#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=56342, encryptionId=4f215634296, topicName=持续时间)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=13e29684821, createdName=zhwj, createdTime=Thu Nov 21 04:12:00 CST 2019, time=2019-11-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1598038, encodeId=fb0615980385c, content=<a href='/topic/show?id=6c6f1e62c5' target=_blank style='color:#2F92EE;'>#ABO#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=1762, encryptionId=6c6f1e62c5, topicName=ABO)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b6c918580135, createdName=闆锋旦, createdTime=Thu Nov 21 04:12:00 CST 2019, time=2019-11-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1050715, encodeId=e1fe1050e15c4, content=代谢组学是热点,它反映疾病的终极状态,通过代谢组学可以反向知道生命体的活动特点,只是目前代谢组成分太复杂,背后的机制仍然不完全清楚而已。, beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=明天jing, createdTime=Tue Nov 19 16:12:00 CST 2019, time=2019-11-19, status=1, ipAttribution=)]
  6. [GetPortalCommentsPageByObjectIdResponse(id=1888090, encodeId=ebac1888090e1, content=<a href='/topic/show?id=d56611584ec' target=_blank style='color:#2F92EE;'>#Meta#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11584, encryptionId=d56611584ec, topicName=Meta)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d8f4110, createdName=guojianrong, createdTime=Tue Jun 30 23:12:00 CST 2020, time=2020-06-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1896580, encodeId=94b1189658032, content=<a href='/topic/show?id=4a391158248' target=_blank style='color:#2F92EE;'>#MET#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11582, encryptionId=4a391158248, topicName=MET)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=18fc139, createdName=一闲, createdTime=Tue Mar 03 06:12:00 CST 2020, time=2020-03-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1306447, encodeId=c1ec130644e5f, content=<a href='/topic/show?id=aeb639230b7' target=_blank style='color:#2F92EE;'>#听力#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=39230, encryptionId=aeb639230b7, topicName=听力)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=96d4340, createdName=ysjykql, createdTime=Thu Nov 21 04:12:00 CST 2019, time=2019-11-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1378953, encodeId=0cb813e895310, content=<a href='/topic/show?id=db548051642' target=_blank style='color:#2F92EE;'>#耳蜗移植#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=80516, encryptionId=db548051642, topicName=耳蜗移植)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=ba58436, createdName=马龙, createdTime=Thu Nov 21 04:12:00 CST 2019, time=2019-11-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1480303, encodeId=f217148030339, content=<a href='/topic/show?id=2f6f2546977' target=_blank style='color:#2F92EE;'>#代谢组#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=25469, encryptionId=2f6f2546977, topicName=代谢组)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0f1e7632392, createdName=ms6897892027066920, createdTime=Thu Nov 21 04:12:00 CST 2019, time=2019-11-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1503669, encodeId=18271503669dd, content=<a href='/topic/show?id=4f215634296' target=_blank style='color:#2F92EE;'>#持续时间#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=56342, encryptionId=4f215634296, topicName=持续时间)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=13e29684821, createdName=zhwj, createdTime=Thu Nov 21 04:12:00 CST 2019, time=2019-11-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1598038, encodeId=fb0615980385c, content=<a href='/topic/show?id=6c6f1e62c5' target=_blank style='color:#2F92EE;'>#ABO#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=1762, encryptionId=6c6f1e62c5, topicName=ABO)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b6c918580135, createdName=闆锋旦, createdTime=Thu Nov 21 04:12:00 CST 2019, time=2019-11-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1050715, encodeId=e1fe1050e15c4, content=代谢组学是热点,它反映疾病的终极状态,通过代谢组学可以反向知道生命体的活动特点,只是目前代谢组成分太复杂,背后的机制仍然不完全清楚而已。, beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=明天jing, createdTime=Tue Nov 19 16:12:00 CST 2019, time=2019-11-19, status=1, ipAttribution=)]
    2019-11-21 zhwj
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    2019-11-21 闆锋旦
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    2019-11-19 明天jing

    代谢组学是热点,它反映疾病的终极状态,通过代谢组学可以反向知道生命体的活动特点,只是目前代谢组成分太复杂,背后的机制仍然不完全清楚而已。

    0

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