复旦郁金泰|Translational Psychiatry:别小看血液生化,他们就能预测发生痴呆症的风险!

2022-08-07 MedSci原创 MedSci原创

维生素D缺乏、GH-IGF-1轴紊乱、生物活性性激素缺乏、肝功能降低、肾功能异常、氧化、胰岛素抵抗、免疫性菌群失调和脂质失调等标志物与发生痴呆有关。

痴呆是一组基本不可逆的神经系统疾病,其特点是记忆力减退、认知障碍和日常生活活动困难,这大大降低了生活质量并造成了巨大的社会负担。随着痴呆症发病率的增加和有效治疗方法的缺乏,目前的趋势表明,确定新的生物标志物和寻找可改变的风险因素,用非侵入性的方法对抗痴呆症的流行是很有必要的。

为此,来自复旦华山的郁金泰教授团队调查了常见的血清实验室测试与发生痴呆症风险的关系,结果发表在Translational Psychiatry杂志。在英国生物库的407190名参与者中(中位随访时间为9.19年),研究人员使用Cox模型和限制性立方样条模型研究了30项实验室检查对全因痴呆风险的线性和非线性影响。

结果发现,痴呆症发病率与低维生素D浓度(HR=0.994,95%CI0.993-0.996)、内分泌失调的指标有关。IGF-1水平(非线性的P=1.1E-05),睾酮水平(非线性的P=0.006);性激素结合球蛋白水平高(HR= 1.004,95%CI:1.003-1.006);肝功能降低:丙氨酸氨基转移酶降低(HR=0.990,95%CI:0.986-0.995);肾功能障碍:胱氨酸C水平(非线性的P=0.028)。

此外,氧化应激:尿酸水平降低(HR=0.998,95% CI:0.998-0.999);血脂失调:低密度脂蛋白(HR=0.918,95% CI:0.872-0.965)和甘油三酯(HR=0. 924,95%CI:0.882-0.967)浓度;胰岛素抵抗:高血糖(HR=1.093,95%CI:1.045-1.143)和HbA1c(HR =1.017,95%CI:1.009-1.025)水平免疫失调,C-反应蛋白(非线性的P=5.5E-09)也与痴呆风险密切相关。

总之,维生素D缺乏、GH-IGF-1轴紊乱、生物活性性激素缺乏、肝功能降低、肾功能异常、氧化、胰岛素抵抗、免疫性菌群失调和脂质失调等标志物与发生痴呆有关。

 

参考文献:

Serum clinical laboratory tests and risk of incident dementia: a prospective cohort study of 407,190 individuals. Transl Psychiatry 12, 312 (2022). https://doi.org/10.1038/s41398-022-02082-x

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    2022-09-25 Boyinsh
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    2022-12-14 bsmagic9140
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    2022-08-09 saikp
  8. [GetPortalCommentsPageByObjectIdResponse(id=1836317, encodeId=ab23183631e5f, content=<a href='/topic/show?id=4613e1212fc' target=_blank style='color:#2F92EE;'>#痴呆症#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=71212, encryptionId=4613e1212fc, topicName=痴呆症)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=726030, createdName=Boyinsh, createdTime=Sun Sep 25 13:53:07 CST 2022, time=2022-09-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1796083, encodeId=75131e9608385, content=<a href='/topic/show?id=8c201e758e5' target=_blank style='color:#2F92EE;'>#translational#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=56, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=17758, encryptionId=8c201e758e5, topicName=translational)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d81c2500028, createdName=12498561m32(暂无昵称), createdTime=Mon May 29 12:53:07 CST 2023, time=2023-05-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1792329, encodeId=100c1e92329d8, content=<a href='/topic/show?id=696a14818df' target=_blank style='color:#2F92EE;'>#Psychiatry#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=52, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=14818, encryptionId=696a14818df, topicName=Psychiatry)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c192448, createdName=diushouji, createdTime=Sat Nov 12 16:53:07 CST 2022, time=2022-11-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2067637, encodeId=ae5c206e63775, content=<a href='/topic/show?id=d0841e75535' target=_blank style='color:#2F92EE;'>#Transl#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=17755, encryptionId=d0841e75535, topicName=Transl)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdqq.qlogo.cn/qqapp/101173734/363C99735735B7F4CB11D5F78F580525/100, createdBy=aab22500211, createdName=ms3025846204744509, createdTime=Sat Jul 08 10:53:07 CST 2023, time=2023-07-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1795963, encodeId=edd61e959634b, content=<a href='/topic/show?id=42211e757d7' target=_blank style='color:#2F92EE;'>#Translation#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=57, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=17757, encryptionId=42211e757d7, topicName=Translation)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdwx.qlogo.cn/mmopen/vi_32/DYAIOgq83eqPdWFricgmt6Dde2ptNxJzD6Y9c4cxpXdTo4pNlVPARAnFdKu6nWIPele9icxApTaFgibq0uVlgRiceQ/132, createdBy=4b8c2500026, createdName=ms8435843352634314, createdTime=Thu Jun 08 05:53:07 CST 2023, time=2023-06-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1657665, encodeId=56c1165e6658a, content=<a href='/topic/show?id=3ca31e71903' target=_blank style='color:#2F92EE;'>#TRA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=17719, encryptionId=3ca31e71903, topicName=TRA)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=757b24868428, createdName=bsmagic9140, createdTime=Wed Dec 14 18:53:07 CST 2022, time=2022-12-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1538655, encodeId=e7d115386551e, content=<a href='/topic/show?id=751e42660f1' target=_blank style='color:#2F92EE;'>#复旦#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=42660, encryptionId=751e42660f1, topicName=复旦)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=e6c312994908, createdName=saikp, createdTime=Tue Aug 09 02:53:07 CST 2022, time=2022-08-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1247166, encodeId=7c2f124e16655, content=老年性痴呆,未来还是希望借助神经电生理吧,也许更为有效!, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=neuro.Dr, createdTime=Sun Aug 07 14:53:07 CST 2022, time=2022-08-07, status=1, ipAttribution=)]
    2022-08-07 neuro.Dr

    老年性痴呆,未来还是希望借助神经电生理吧,也许更为有效!

    0

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