JAHA:年青1型糖尿病患者的心血管危险因素和动脉僵化负担

2019-06-21 xing.T MedSci原创

在患有T1DM的年轻人中,持续的低血糖控制和较高水平的传统CVRF与动脉衰老独立相关。改善血糖控制和降低CVRF干预可以预防T1DM患者的心血管事件。

儿童中1型糖尿病(T1DM)的发病率正在增加,由糖尿病相关的血管功能障碍导致的心血管疾病负担更高。

近日,心血管疾病领域权威杂志JAHA上发表了一篇研究文章,研究人员评估了1809名T1DM青年的心血管危险因素(CVRF)和动脉参数。在T1DM发病和5年后收集人口统计学指标、人体测量学指标、血压和实验室数据。用眼压计收集脉搏波速度和增强指数。ANOVA或卡方检验用于分析CVRF测量动脉参数的差异。将CVRF曲线下面积输入一般线性模型,以探索加速血管老化的决定因素。

动脉测量时参与者的平均年龄为17.6±4.5岁,50%为女性,76%为非西班牙裔白人,T1DM病程为7.8±1.9年。血糖控制差(糖化血红蛋白为9.1±1.8%),糖化血红蛋白≥9%的参与者的所有动脉参数均较高,脉搏波速度较高,胰岛素敏感性较低或糖尿病病程较长。通过性别、年龄和肥胖、高血压或血脂异常的存在发现动脉参数的差异。在多变量模型中,较高的糖化血红蛋白、较低的胰岛素敏感性、体重指数、血压和脂质的曲线下面积与加速的血管老化相关。

在患有T1DM的年轻人中,持续的低血糖控制和较高水平的传统CVRF与动脉衰老独立相关。改善血糖控制和降低CVRF干预可以预防T1DM患者的心血管事件。 

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    2019-06-23 zhaohui6731
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    2019-06-21 misszhang

    谢谢MedSci提供最新的资讯

    0