Sci Rep:机器人辅助腹腔镜前列腺癌根治术中异丙酚对炎症反应的作用研究

2019-04-14 AlexYang MedSci原创

机器人辅助的腹腔镜前列腺癌根治术(RALRP)是一种微创手术;然而,一些外科手术创伤仍旧能够激发系统炎症。更多的是,RALRP期间的腹腔集气能够诱导再灌注损伤(IRI)。异丙酚是一种麻醉剂,且已知其具有抗炎症和抗氧化的特性。最近,有研究人员比较了异丙酚与地氟醚在RALRP中的炎症和IRI中的作用,具体是通过测量不同的生物标记和围手术期肾功能评估来比较的。研究包括了50名接受地氟醚(n=25)或者异

机器人辅助的腹腔镜前列腺癌根治术(RALRP)是一种微创手术;然而,一些外科手术创伤仍旧能够激发系统炎症。更多的是,RALRP期间的腹腔集气能够诱导再灌注损伤(IRI)。异丙酚是一种麻醉剂,且已知其具有抗炎症和抗氧化的特性。

最近,有研究人员比较了异丙酚与地氟醚在RALRP中的炎症和IRI中的作用,具体是通过测量不同的生物标记和围手术期肾功能评估来比较的。研究包括了50名接受地氟醚(n=25)或者异丙酚(n=25)以及瑞芬太尼治疗的患者。研究发现,在2个小组中,尽管异丙酚组中的IL-6的增加被明显的削弱,T2和T3时期的IL-6水平还是要比T1时期更高。其他参数在2个小组中的3个时间点上并没有表现出差异。另外,异丙酚组中的术中尿量要比地氟醚组显著更高,而肌酸酐水平在任何1个小组中都没有明显的变化。

最后,研究人员指出,他们的发现表明了异丙酚不仅能够在经历RALRP患者腹腔集气期间和之后减弱他们的炎症反应,还能够阻止腹腔集气期间减少尿量。

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2019, time=2019-04-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1040435, encodeId=bd7f1040435b8, content=前列腺癌相关研究,学习了,谢谢梅斯, beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=misszhang, createdTime=Sun Apr 14 17:46:00 CST 2019, time=2019-04-14, status=1, ipAttribution=)]
    2019-04-16 xue8602
  5. 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  6. 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    2019-04-16 lq0303
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    2019-04-16 jeanqiuqiu
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    2019-04-14 misszhang

    前列腺癌相关研究,学习了,谢谢梅斯

    0

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