Gut:活动性炎症性肠炎增加患者动脉血管事件发生率

2017-06-25 zhangfan MedSci原创

炎症性肠炎患者其急性动脉血管事件发生率上升,特别是中年人群,活动性疾病独立增加患者血管风险

炎症性肠炎(IBD)患者急性血管事件风险的大小和独立驱动因素尚不清楚,近日研究人员比较了IBD患者与健康人群急性血管事件风险差异。

研究人员利用法国国立医院数据库,分析了2008-13年间,15岁以上IBD患者资料,利用Cox模型研究了急性动脉事件发生率与IBD疾病活动的影响。

研究包含了210162名IBD患者,其中克罗恩病(CD)97708例,溃疡性结肠炎(UC)患者112454例,发生了5554起急性动脉事件。CD与UC显著增加急性动脉事件风险(CD:校准事件率[SIR]1.35; 95% CI 1.30 —1.41 ,UC:SIR 1.10; 95 CI 1.06 —1.13),其中55岁患者的动脉事件风险最高。活动性IBD相关住院事件会显著增加急性动脉事件发生率(3个月前发生:HR,1.74; 95 CI 1.44 —2.09,3个月内发生:HR 1.87; 95% CI 1.58 —2.22)。

研究表明,炎症性肠炎患者其急性动脉血管事件发生率上升,特别是中年人群,活动性疾病独立增加患者血管风险。

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  5. 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href='/topic/show?id=4ef26e01766' target=_blank style='color:#2F92EE;'>#炎症性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=67017, encryptionId=4ef26e01766, topicName=炎症性)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=09e813968720, createdName=12498dd9m15暂无昵称, createdTime=Tue Jun 27 01:16:00 CST 2017, time=2017-06-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=215226, encodeId=72c3215226e1, content=学习了,谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=61, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/Q3auHgzwzM4o2XVpJ6449yqDsjibydI5HnJ8MibGxNn4HZiaZib0bdfibbwoz3KQrIyN9AGxq36ZlZRNicYlPfOOWMtwgsajY6mGNFiaPclFdowjD0/0, createdBy=97bd1338592, createdName=清风拂面, createdTime=Sun Jun 25 13:29:28 CST 2017, time=2017-06-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=215190, encodeId=1e3a2151908d, content=炎症性肠炎背后可能是有共同的一个炎症反应,而炎症反应他也会增加心血管事件的发生,一般认为很多心血管疾病背后都是一些微炎症, beContent=null, objectType=article, channel=null, level=null, likeNumber=76, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=c4a5105539, createdName=lovetcm, createdTime=Sun Jun 25 11:02:54 CST 2017, time=2017-06-25, status=1, ipAttribution=)]
    2017-07-06 虈亣靌

    学习谢谢分享

    0

  6. 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href='/topic/show?id=4ef26e01766' target=_blank style='color:#2F92EE;'>#炎症性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=67017, encryptionId=4ef26e01766, topicName=炎症性)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=09e813968720, createdName=12498dd9m15暂无昵称, createdTime=Tue Jun 27 01:16:00 CST 2017, time=2017-06-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=215226, encodeId=72c3215226e1, content=学习了,谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=61, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/Q3auHgzwzM4o2XVpJ6449yqDsjibydI5HnJ8MibGxNn4HZiaZib0bdfibbwoz3KQrIyN9AGxq36ZlZRNicYlPfOOWMtwgsajY6mGNFiaPclFdowjD0/0, createdBy=97bd1338592, createdName=清风拂面, createdTime=Sun Jun 25 13:29:28 CST 2017, time=2017-06-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=215190, encodeId=1e3a2151908d, content=炎症性肠炎背后可能是有共同的一个炎症反应,而炎症反应他也会增加心血管事件的发生,一般认为很多心血管疾病背后都是一些微炎症, beContent=null, objectType=article, channel=null, level=null, likeNumber=76, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=c4a5105539, createdName=lovetcm, createdTime=Sun Jun 25 11:02:54 CST 2017, time=2017-06-25, status=1, ipAttribution=)]
    2017-06-28 天涯183

    非常好的文章,学习了,很受益

    0

  7. 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topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7LIiaRZTzJ3SEfiauCzTMPW7YvPPYLNJBXG9oh6Al1icq2VQQkIHWxqXehcicTS62YKJVBhxeth3wggw/0, createdBy=7ce01621306, createdName=天涯183, createdTime=Wed Jun 28 14:26:40 CST 2017, time=2017-06-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=215996, encodeId=5961215996be, content=很值得期待,据说很好, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zMoyicyo6ia9f4IuLQAwZoxD6Hx4ibd5CMcOCYhStY6oDibbKK6O2X8iaicldO5ib8j1iapOIobIKCGiczU2A/0, createdBy=56251941490, createdName=虈亣靌, createdTime=Tue Jun 27 14:15:26 CST 2017, time=2017-06-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1547053, encodeId=a24d154e05358, content=<a href='/topic/show?id=4ef26e01766' target=_blank style='color:#2F92EE;'>#炎症性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=67017, encryptionId=4ef26e01766, topicName=炎症性)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=09e813968720, createdName=12498dd9m15暂无昵称, createdTime=Tue Jun 27 01:16:00 CST 2017, time=2017-06-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=215226, encodeId=72c3215226e1, content=学习了,谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=61, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/Q3auHgzwzM4o2XVpJ6449yqDsjibydI5HnJ8MibGxNn4HZiaZib0bdfibbwoz3KQrIyN9AGxq36ZlZRNicYlPfOOWMtwgsajY6mGNFiaPclFdowjD0/0, createdBy=97bd1338592, createdName=清风拂面, createdTime=Sun Jun 25 13:29:28 CST 2017, time=2017-06-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=215190, encodeId=1e3a2151908d, content=炎症性肠炎背后可能是有共同的一个炎症反应,而炎症反应他也会增加心血管事件的发生,一般认为很多心血管疾病背后都是一些微炎症, beContent=null, objectType=article, channel=null, level=null, likeNumber=76, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=c4a5105539, createdName=lovetcm, createdTime=Sun Jun 25 11:02:54 CST 2017, time=2017-06-25, status=1, ipAttribution=)]
    2017-06-27 虈亣靌

    很值得期待,据说很好

    0

  8. 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topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7LIiaRZTzJ3SEfiauCzTMPW7YvPPYLNJBXG9oh6Al1icq2VQQkIHWxqXehcicTS62YKJVBhxeth3wggw/0, createdBy=7ce01621306, createdName=天涯183, createdTime=Wed Jun 28 14:26:40 CST 2017, time=2017-06-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=215996, encodeId=5961215996be, content=很值得期待,据说很好, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zMoyicyo6ia9f4IuLQAwZoxD6Hx4ibd5CMcOCYhStY6oDibbKK6O2X8iaicldO5ib8j1iapOIobIKCGiczU2A/0, createdBy=56251941490, createdName=虈亣靌, createdTime=Tue Jun 27 14:15:26 CST 2017, time=2017-06-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1547053, encodeId=a24d154e05358, content=<a 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  9. 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time=2017-06-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=215190, encodeId=1e3a2151908d, content=炎症性肠炎背后可能是有共同的一个炎症反应,而炎症反应他也会增加心血管事件的发生,一般认为很多心血管疾病背后都是一些微炎症, beContent=null, objectType=article, channel=null, level=null, likeNumber=76, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=c4a5105539, createdName=lovetcm, createdTime=Sun Jun 25 11:02:54 CST 2017, time=2017-06-25, status=1, ipAttribution=)]
    2017-06-25 清风拂面

    学习了,谢谢分享

    0

  10. 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href='/topic/show?id=4ef26e01766' target=_blank style='color:#2F92EE;'>#炎症性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=67017, encryptionId=4ef26e01766, topicName=炎症性)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=09e813968720, createdName=12498dd9m15暂无昵称, createdTime=Tue Jun 27 01:16:00 CST 2017, time=2017-06-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=215226, encodeId=72c3215226e1, content=学习了,谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=61, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/Q3auHgzwzM4o2XVpJ6449yqDsjibydI5HnJ8MibGxNn4HZiaZib0bdfibbwoz3KQrIyN9AGxq36ZlZRNicYlPfOOWMtwgsajY6mGNFiaPclFdowjD0/0, createdBy=97bd1338592, createdName=清风拂面, createdTime=Sun Jun 25 13:29:28 CST 2017, time=2017-06-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=215190, encodeId=1e3a2151908d, content=炎症性肠炎背后可能是有共同的一个炎症反应,而炎症反应他也会增加心血管事件的发生,一般认为很多心血管疾病背后都是一些微炎症, beContent=null, objectType=article, channel=null, level=null, likeNumber=76, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=c4a5105539, createdName=lovetcm, createdTime=Sun Jun 25 11:02:54 CST 2017, time=2017-06-25, status=1, ipAttribution=)]
    2017-06-25 lovetcm

    炎症性肠炎背后可能是有共同的一个炎症反应,而炎症反应他也会增加心血管事件的发生,一般认为很多心血管疾病背后都是一些微炎症

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