JAHA:妊娠并发症与心血管疾病风险的关系

2022-01-12 MedSci原创 MedSci原创

在这项大型队列研究中,妊娠并发症与全因死亡率、心血管死亡率和因CVD住院相关,在调整混杂因素(包括超重、吸烟和合并症)后也是如此。

妊娠并发症是未来心血管疾病(CVD)已知的危险因素。有妊娠并发症(如先兆子痫、妊娠期高血压(GHT)和妊娠糖尿病)病史的女性患CVD的风险增加。孕产妇妊娠并发症与CVD之间的关联已得到充分证明。一般而言,胎儿并发症与CVD之间的关联尚未明确,尽管早产、小于胎龄儿(SGA)和死产的CVD风险增加。

近日,心血管疾病领域权威杂志JAHA上发表了一篇研究文章,该研究旨在调查妊娠并发症与调整了主要混杂因素后心血管死亡率和心血管疾病(CVD)住院率之间的关联。

在这项全国性的基于登记中心的队列研究中,瑞典医学出生登记处纳入了1973年至2014年期间单胎出生的女性。从死亡原因登记中心和国家住院登记中心收集了心血管疾病的死亡率和住院结局。从第一次分娩之日起对该队列进行随访,直至死亡或随访结束,以先发生者为准。研究的妊娠并发症是先兆子痫或子痫、妊娠期高血压、妊娠期糖尿病、早产、小于胎龄儿和死产。

在2134239名女性受试者中(第一次妊娠的平均年龄为27.0岁[SD为5.1],平均产次为1.96[SD为0.9]),19.1%的受试者(N=407597)有1种妊娠并发症。在对Cox比例风险回归模型中的主要混杂因素进行调整后,所有妊娠并发症都与全因和心血管死亡率以及CVD(缺血性心脏病、缺血性卒中和外周动脉疾病)住院相关。早产的心血管死亡率调整后的风险比为1.84(95%CI为1.38-2.44),死产为3.14(95%CI为1.81-5.44)。

由此可见,在这项大型队列研究中,妊娠并发症与全因死亡率、心血管死亡率和因CVD住院相关,在调整混杂因素(包括超重、吸烟和合并症)后也是如此。该研究强调,早产和死产等不太确定的妊娠并发症也与心血管死亡率和心血管疾病相关。

原始出处:

Elin Täufer Cederlöf,et al.Pregnancy Complications and Risk of Cardiovascular Disease Later in Life: A Nationwide Cohort Study.JAHA.2022.https://www.ahajournals.org/doi/10.1161/JAHA.121.023079

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    2022-03-27 丁鹏鹏
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    2022-01-14 zhaohui6731
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    2022-01-13 泡泡糖111

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