AP&T: D型人格与炎症性肠病患者的抑郁症状和临床疾病活动有关

2021-06-24 MedSci原创 MedSci原创

炎症性肠病 (IBD) 包括克罗恩病 (CD)、溃疡性结肠炎 (UC) 和未分类的 IBD (IBDu)三种亚型。

      炎症性肠病 (IBD) 包括克罗恩病 (CD)、溃疡性结肠炎 (UC) 和未分类的 IBD (IBDu)三种亚型,影响着超过 200 万欧洲人和 150 万北美人。抑郁和焦虑已被证明是临床疾病复发的诱因。目前尚不清楚哪些 IBD 患者特别脆弱会容易出现焦虑或抑郁的症状。D型人格,也就是所谓的易恼型人格倾向于体验负面情感,在对 5000 多名冠心病患者的荟萃分析中,D 型显着增加了冠心病的风险。本项研究旨在评估 IBD 患者中 D 型人格的患病率并评估与病程的潜在关联。

 

      研究人员在瑞士一家医疗中心的 IBD 队列患者中测试了人格测试、抑郁症状(医院焦虑和抑郁量表的抑郁评分≥11)和复发性 IBD的关系。使用Cox 比例风险模型建立了回归模型,用于事件分析。IBD相关疾病评估是通过活动性疾病(克罗恩病活动指数≥ 150)和几个 IBD 相关终点进行评估。

 

      在 2275 名患者(1005 名溃疡性结肠炎,1270 名克罗恩病)中,672 名(29.5%)为 D 型人格。D 型人格是远期IBD疾病复发的重要危险因素(调整后的风险比,aHR:1.60,P=0.007),并与未来出现的抑郁症状有相关性(aHR:3.30,P< 0.001)。D 型人格和抑郁症状的组合进一步增加了活动性疾病的风险(aHR:3.98,q < 0.001)。

图:D型人格对于疾病复发的影响

      本项研究证实D型人格在 IBD 患者中的患病率与其在一般人群中的患病率相当。但D 型人格与抑郁症状密切相关,并与 IBD 的疾病复发独立关联。

 

 

原始出处:

Sebastian Bruno Ulrich Jordi. Et al. Type D personality is associated with depressive symptoms and clinical activity in inflammatory bowel disease. Alimentary Pharmacology & Therapeutics.2021.

 

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    2021-06-27 liuzhuli

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    0

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    2021-06-26 ms6000000079288216

    学习了,有用

    0

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    2021-06-25 wml_guyue

    学习了

    0

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    2021-06-25 ms854966

    感谢分享

    0

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    2021-06-25 小小医者

    别试了,真的复制不下来[我想静静][我想静静][我想静静]𓆗𓆏𓆌𓆉𓆈𓅰𓅭𓅪𓅦𓅜𓄿𓃻𓃹𓃷𓃵𓃲𓃱𓃰𓃯𓃬𓆧𓆦𓆣𓆡𓆟𓆗𓆏𓆌𓆉𓆈𓅰𓅭𓅪𓅦𓆗𓆏𓆌𓆉𓆈𓅰𓅭𓅪𓅦𓅜𓄿𓃻𓃹𓃷𓃵𓃲𓃱𓃰𓃯𓃬𓆧𓆦𓆣𓆡𓆟𓆗𓆏𓆌𓆉𓆈𓅰𓅭𓅪𓅦𓆗𓆏𓆌𓆉𓆈𓅰𓅭𓅪𓅦𓅜𓄿𓃻𓃹𓃷𓃵𓃲𓃱𓃰𓃯𓃬𓆧𓆦𓆣𓆡𓆟𓆗𓆏𓆌𓆉𓆈𓅰𓅭𓅪𓅦

    0

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