Arthritis Rheumatol:类风湿关节炎患者与健康人的口腔微生物差别

2021-11-20 xiangting MedSci原创

与健康对照组相比,早期 RA 患者和RA高危个体的口腔微生物组相似,两者口腔微生物的特征是潜在促炎菌种的相对丰度升高。

尽管遗传因素对类风湿关节炎(RA)有明确影响,然而环境因素同样起到了十分重要的作用。有研究表明,类风湿关节炎最初是由肠道微生物引发的免疫反应导致的,不过消化道来源的自体免疫反应对于类风湿性关节炎到底有怎样的影响仍不清楚。这项研究评估了与健康对照相比,早期 RA 患者和有患 RA 风险的个体口腔微生物组和牙周状况的差别。

                 

研究招募了三组受试者(每组50名):1) 早期 RA 患者(符合美国风湿病学会/欧洲风湿病协会联盟 2010年分类标准),2) 有发展为 RA 风险的个体(关节痛患者、RA 相关自身抗体阳性),和 3)健康对照。进行牙周检查评估探诊出血 (BOP)、牙周袋探诊深度 (PPD) 和牙周炎症表面积 (PISA) 。使用 16S 核糖体 DNA 扩增子测序评估龈下牙菌斑、唾液和舌苔的微生物组成,并使用置换多变量方差分析 (PERMANOVA) 比较各组差异。

早期RA 患者、高危个体和健康对照的3个牙周指标均没有显著差异(BOP P = 0.70,PPD P = 0.30 ,PISA P = 0.57)。PERMANOVA 分析比较组间的微生物组成,结果发现唾液(F=2.08,P=0.0002)和舌苔(F=2.04,P=0.008)的微生物组成存在显著差异,但龈下牙菌斑没有差异(F=0.948,P = 0.51)。然而在事后测试中,早期 RA 组和高危组的唾液或舌苔微生物组成不存在显著差异(唾液F=1.12,P = 0.28;舌苔F=0.834,P=0.59)。与健康对照相比,早期RA患者和高危个体唾液中的普里沃菌,以及唾液和舌苔中的韦荣球菌相对丰度较高。

                                  三组间口腔微生物相对丰度的比较

由此可见,与健康对照组相比,早期 RA 患者和RA高危个体的口腔微生物组相似,两者口腔微生物的特征是潜在促炎菌种的相对丰度升高。这些结果表明口腔微生物组与 RA 发病之间可能存在关联。

 

原始出处:

Johanna M. Kroese. Differences in the Oral Microbiome in Patients With Early Rheumatoid Arthritis and Individuals at Risk of Rheumatoid Arthritis Compared to Healthy Individuals. Arthritis Rheumatol. November 2021.

 

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  5. 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time=2021-11-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1357828, encodeId=849d135e8285f, content=<a href='/topic/show?id=b0702e84b9' target=_blank style='color:#2F92EE;'>#ART#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2784, encryptionId=b0702e84b9, topicName=ART)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=zhaojie88, createdTime=Sun Nov 21 03:12:53 CST 2021, time=2021-11-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1597417, encodeId=5207159e417d3, content=<a href='/topic/show?id=fa1710082017' target=_blank style='color:#2F92EE;'>#风湿关节炎#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=100820, encryptionId=fa1710082017, topicName=风湿关节炎)], attachment=null, 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    2021-11-21 1031264886

    学习了

    0

  6. 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    2021-11-21 lmm397
  7. 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  8. 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    2021-11-21 zhaojie88
  9. 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