Autophagy:浙江大学周继勇课题组阐释狂犬病毒复制的自噬机制

2017-02-27 佚名 生物帮

2017年2月23日,国际著名自噬领域学术期刊《Autophagy》在线发表在线发表了浙江大学动物科学学院农业部动物病毒学重点实验室周继勇教授课题组题为“BECN1-dependent CASP2 incomplete autophagy induction by binding to rabies virus phosphoprotein”的论文。

2017年2月23日,国际著名自噬领域学术期刊《Autophagy》在线发表在线发表了浙江大学动物科学学院农业部动物病毒学重点实验室周继勇教授课题组题为“BECN1-dependent CASP2 incomplete autophagy induction by binding to rabies virus phosphoprotein”的论文。课题组揭示了细胞自噬在狂犬病毒复制生命周期中的关键作用。博士研究生刘娟是论文的第一作者,周继勇为通讯作者。

狂犬病是世界上最古老的人兽共患传染病,感染后的发病及死亡率为100%,是至今发病后无治疗措施的传染病,目前全世界每年大约59000人感染该病死亡。亚洲国家的发病率和死亡率位居全球首位,中国人每年的狂犬病发病率和死亡率位居全世界第二位。因此,深入了解狂犬病毒的复制及发病机理、寻找感染早期的诊断标志物和治疗药物设计靶点、开发治疗性疫苗是狂犬病防治研究的重点和前沿。

由于技术难度,目前对狂犬病毒复制机制的了解知之甚少。课题组利用动物和细胞模型,首次证明了狂犬病毒感染过程中BECN1与Caspase 2(含半胱氨酸的天冬氨酸蛋白水解酶)-AMPK(AMP依赖的蛋白激酶)- AKT-MTOR及MAPK(丝裂原活化蛋白)的通路连接。在此基础上,证明了狂犬病毒通过其编码的磷蛋白P与BENC1结合,借助CASP2-AMPK-MAPK/AKT-MTOR信号途径激活不完全自噬,阐释了狂犬病病毒利用不完全自噬完成复制的分子机制。



原始出处

Juan Liu, Hailong Wang, Jinyan Gu, et al. BECN1-dependent CASP2 incomplete autophagy induction by binding to rabies virus phosphoprotein. Autophagy  2017.doi:10.1080/15548627.2017.1280220.

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    2017-03-31 凨小宅

    厉害

    0

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    2017-02-28 吴教授

    学习了,虽然不大懂。

    0

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