Eur Heart J:残余胆固醇可预测心血管疾病

2021-07-24 MedSci原创 MedSci原创

在无ASCVD的个体中,升高的RC水平与ASCVD相关,且独立于传统的危险因素、LDL-C和apoB水平。

新出现的证据表明,残余胆固醇(RC)会促进动脉粥样硬化性血管疾病(ASCVD)。

近日,心血管领域权威杂志Eur Heart J上发表了一篇研究文章,研究人员旨在评估无ASCVD的患者相比于低密度脂蛋白胆固醇(LDL-C)和载脂蛋白B(apoB)之外RC的相关风险。

研究人员汇总了来自社区动脉粥样硬化风险研究(n=9748)、动脉粥样硬化的多种族研究(n=3049)和年轻人冠状动脉风险的发展研究(n=4735)的17532名无ASCVD个体的数据。研究人员通过非高密度脂蛋白胆固醇(非HDL-C)减去LDL-C获得RC,并使用调整后的Cox模型来估计与logRC水平相关的ASCVD事件风险。

参与者的平均年龄为52.3±17.9岁,56.7%为女性,34%为黑人。在中位随访18.7年期间,共有2143起ASCVD事件。在包括LDL-C和apoB在内的多变量调整后,logRC与较高的ASCVD风险相关[风险比(HR)为1.65,95%置信区间(CI)为1.45–1.89]。此外,与一致组相比,不一致的高RC/低LDL-C组,而不是低RC/高LDL-C组与ASCVD风险增加相关(HR为1.21,95%CI为1.08-1.35)。在评估跨临界点的不一致时也具有类似的结果。

在无ASCVD的个体中,升高的RC水平与ASCVD相关,且独立于传统的危险因素、LDL-C和apoB水平。

原始出处:

Renato Quispe.et al.Remnant cholesterol predicts cardiovascular disease beyond LDL and ApoB: a primary prevention study.European Heart Journal.2021.https://doi.org/10.1093/eurheartj/ehab432

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createdName=Angela Yu, createdTime=Sat Jul 24 10:55:39 CST 2021, time=2021-07-24, status=1, ipAttribution=)]
    2021-12-09 ms3000001750303968

    学习了,谢谢!

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    2021-09-26 452946589

    学习了,设计研究模型

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    2021-07-26 施卫平

    增长了知识,謝謝!

    0

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createdName=Angela Yu, createdTime=Sat Jul 24 10:55:39 CST 2021, time=2021-07-24, status=1, ipAttribution=)]
  5. 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style='color:#2F92EE;'>#ART#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2784, encryptionId=b0702e84b9, topicName=ART)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=zhaojie88, createdTime=Mon Jul 26 01:37:27 CST 2021, time=2021-07-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1498921, encodeId=1bfb1498921f8, content=<a href='/topic/show?id=bb6f89e145a' target=_blank style='color:#2F92EE;'>#血管疾病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=89714, encryptionId=bb6f89e145a, topicName=血管疾病)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ccb99370406, createdName=andy2090, createdTime=Mon Jul 26 01:37:27 CST 2021, time=2021-07-26, status=1, ipAttribution=), 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Jul 24 19:23:41 CST 2021, time=2021-07-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1002329, encodeId=776b10023296c, content=非常受用, beContent=null, objectType=article, channel=null, level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210724/725901dc0ed249ebba9d096aacddde3f/a89b874e17434adb82b0c2dff5f374f1.jpg, createdBy=c0225555986, createdName=@gxl, createdTime=Sat Jul 24 19:02:18 CST 2021, time=2021-07-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1002189, encodeId=dc24100218989, content=学习啦~谢谢, beContent=null, objectType=article, channel=null, level=null, likeNumber=49, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210627/0e8142bbb4a04eb78e71a2d739e0aac0/4a0cee7114594824a0a9903ac1495565.jpg, createdBy=c9e91732173, createdName=Angela Yu, createdTime=Sat Jul 24 10:55:39 CST 2021, time=2021-07-24, status=1, ipAttribution=)]
    2021-07-26 zhaojie88
  6. 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createdName=Angela Yu, createdTime=Sat Jul 24 10:55:39 CST 2021, time=2021-07-24, status=1, ipAttribution=)]
  7. [GetPortalCommentsPageByObjectIdResponse(id=1078505, encodeId=08af10e85050b, content=学习了,谢谢!, beContent=null, objectType=article, channel=null, level=null, likeNumber=54, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=08bd5735710, createdName=ms3000001750303968, createdTime=Thu Dec 09 17:23:45 CST 2021, time=2021-12-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1055181, encodeId=70851055181bd, content=学习了,设计研究模型, beContent=null, objectType=article, channel=null, level=null, likeNumber=60, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=df324723890, createdName=452946589, createdTime=Sun Sep 26 22:26:12 CST 2021, time=2021-09-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1002650, encodeId=43f310026501c, content=增长了知识,謝謝!, beContent=null, objectType=article, 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createdName=Angela Yu, createdTime=Sat Jul 24 10:55:39 CST 2021, time=2021-07-24, status=1, ipAttribution=)]
    2021-07-26 slcumt
  8. 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style='color:#2F92EE;'>#ART#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2784, encryptionId=b0702e84b9, topicName=ART)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=zhaojie88, createdTime=Mon Jul 26 01:37:27 CST 2021, time=2021-07-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1498921, encodeId=1bfb1498921f8, content=<a href='/topic/show?id=bb6f89e145a' target=_blank style='color:#2F92EE;'>#血管疾病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=89714, encryptionId=bb6f89e145a, topicName=血管疾病)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ccb99370406, createdName=andy2090, createdTime=Mon Jul 26 01:37:27 CST 2021, time=2021-07-26, status=1, ipAttribution=), 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Jul 24 19:23:41 CST 2021, time=2021-07-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1002329, encodeId=776b10023296c, content=非常受用, beContent=null, objectType=article, channel=null, level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210724/725901dc0ed249ebba9d096aacddde3f/a89b874e17434adb82b0c2dff5f374f1.jpg, createdBy=c0225555986, createdName=@gxl, createdTime=Sat Jul 24 19:02:18 CST 2021, time=2021-07-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1002189, encodeId=dc24100218989, content=学习啦~谢谢, beContent=null, objectType=article, channel=null, level=null, likeNumber=49, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210627/0e8142bbb4a04eb78e71a2d739e0aac0/4a0cee7114594824a0a9903ac1495565.jpg, createdBy=c9e91732173, createdName=Angela Yu, createdTime=Sat Jul 24 10:55:39 CST 2021, time=2021-07-24, status=1, ipAttribution=)]
    2021-07-24 @gxl

    非常受用

    0

  9. 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Jul 24 19:23:41 CST 2021, time=2021-07-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1002329, encodeId=776b10023296c, content=非常受用, beContent=null, objectType=article, channel=null, level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210724/725901dc0ed249ebba9d096aacddde3f/a89b874e17434adb82b0c2dff5f374f1.jpg, createdBy=c0225555986, createdName=@gxl, createdTime=Sat Jul 24 19:02:18 CST 2021, time=2021-07-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1002189, encodeId=dc24100218989, content=学习啦~谢谢, beContent=null, objectType=article, channel=null, level=null, likeNumber=49, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210627/0e8142bbb4a04eb78e71a2d739e0aac0/4a0cee7114594824a0a9903ac1495565.jpg, createdBy=c9e91732173, createdName=Angela Yu, createdTime=Sat Jul 24 10:55:39 CST 2021, time=2021-07-24, status=1, ipAttribution=)]
    2021-07-24 @gxl

    非常受用

    0

  10. 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Jul 24 19:23:41 CST 2021, time=2021-07-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1002329, encodeId=776b10023296c, content=非常受用, beContent=null, objectType=article, channel=null, level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210724/725901dc0ed249ebba9d096aacddde3f/a89b874e17434adb82b0c2dff5f374f1.jpg, createdBy=c0225555986, createdName=@gxl, createdTime=Sat Jul 24 19:02:18 CST 2021, time=2021-07-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1002189, encodeId=dc24100218989, content=学习啦~谢谢, beContent=null, objectType=article, channel=null, level=null, likeNumber=49, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210627/0e8142bbb4a04eb78e71a2d739e0aac0/4a0cee7114594824a0a9903ac1495565.jpg, createdBy=c9e91732173, createdName=Angela Yu, createdTime=Sat Jul 24 10:55:39 CST 2021, time=2021-07-24, status=1, ipAttribution=)]
    2021-07-24 Angela Yu

    学习啦~谢谢

    0

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