AJG:年轻男性的性激素结合球蛋白水平与中年非酒精性脂肪肝相关

2019-06-19 不详 MedSci原创

有研究数据显示,患有非酒精性脂肪性肝病(NAFLD)的男性睾酮和性激素结合球蛋白(SHBG)水平较低。目前尚不清楚年轻男性的性激素水平是否可预测NAFLD的预后结局,因此,本项研究旨在探究这二者之间的关系。

背景及目的:
有研究数据显示,患有非酒精性脂肪性肝病(NAFLD)的男性睾酮和性激素结合球蛋白(SHBG)水平较低。目前尚不清楚年轻男性的性激素水平是否可预测NAFLD的预后结局,因此,本项研究旨在探究这二者之间的关系。

方法:
研究人员从一项前瞻性多中心年轻成人冠状动脉风险发展研究(平均年龄50岁; n = 837)的男性数据库中进行数据收集,并评估了在研究第10年的NAFLD发生是否与在研究第25周时的睾酮和SHBG水平有关.NAFLD的诊断是在排除其他肝脏脂肪变性原因后使用CT扫描确诊的。通过Logistic回归评估睾酮和SHBG与NAFLD的关联。

结果:
年轻男性的总睾酮水平与中年时NAFLD的发生呈负相关(比值比[OR] 0.64,95%置信区间0.53-0.7,P <0.001),相反,SHBG与NAFLD的发生存在显着的负相关关系,与睾酮和代谢协变量无关(OR 0.68,OR 0.51-0.92,P = 0.013)。同时研究人员发现内脏脂肪可解释较低SHBG与NAFLD相关性。

结论:
年轻男性SHBG水平较低与中年人群NAFLD发生风险增加有关,与综合代谢危险因素无关。SHBG可能为年轻男性提供新的NAFLD风险标记。

原始出处:

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    2019-09-23 minzju5052
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    2020-01-26 xzw113
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