研究发现胰腺癌的四种新亚型

2016-02-26 Jeffrey MedSci原创

胰腺癌——“癌中之王”。据全球肿瘤流行病统计数据(GLOBOCAN)显示,世界范围内胰腺癌是排名第13位的常见肿瘤,且在西方国家肿瘤相关死亡中排名第4。目前约有99%的胰腺癌患者死亡。因其很难被及早发现,且患者生存期短,死亡率高,预后极差,成为当前临床治疗中相当棘手的一种癌症。图片来源:www.nsh.uk近日,发表于同行评议杂志Nature上研究论文中,来自全球40多个机构的研究人员分析发现,胰

胰腺癌——“癌中之王”。据全球肿瘤流行病统计数据(GLOBOCAN)显示,世界范围内胰腺癌是排名第13位的常见肿瘤,且在西方国家肿瘤相关死亡中排名第4。目前约有99%的胰腺癌患者死亡。因其很难被及早发现,且患者生存期短,死亡率高,预后极差,成为当前临床治疗中相当棘手的一种癌症。


图片来源:www.nhs.uk

近日,发表于同行评议杂志Nature上研究论文中,来自全球40多个机构的研究人员分析发现,胰腺癌可分为四种亚型:鳞状上皮肿瘤、胰腺祖细胞瘤、ADEX肿瘤和免疫原性肿瘤。这一研究发现或许将有助于找到新的治疗方法,改变胰腺癌长期以来难以治疗的状况。

这是一个实验性研究,研究人员利用基因测序技术和计算机分析456个胰腺肿瘤的基因突变方式。研究发现胰腺癌中有32种基因发生明显突变,它们与引发癌症的10种分子机制相关。并根据基因突变引发癌症的不同机制将胰腺癌为分四种亚型:

鳞状上皮肿瘤——这些肿瘤在胰腺癌中更具侵袭性并快速蔓延。
胰腺祖细胞瘤——胰腺细胞生长的转录网发生错误。
ADEX(异常分化内分泌腺)肿瘤——胰腺祖细胞瘤的一个亚型,特定基因过表达,破坏胰腺正常生长。
免疫原性肿瘤——破坏识别癌细胞并保护它们的免疫系统。

研究者称,这一研究结果有助于他们推断胰腺癌亚型分子进化的差异性,并找出新的治疗方法。不同类型肿瘤可能有不同致病因,找到这些原因可以帮助我们更好地治疗胰腺癌。特别是对于免疫原性肿瘤,对癌细胞生长和增殖过程中免疫系统作用新的认识,有助于我们研发新的治疗方法,特异性破坏肿瘤逃避免疫系统攻击的机制。

研究人员表示,新药已经被用于临床试验治疗其它癌症,未来也将会应用此药治疗“胰腺癌新的免疫原性亚型”。但至于是否真的有效还需临床试验验证。

从研究中我们还无法知道所有四种胰腺癌都能获得新的治疗方法。我们也不知道对胰腺癌患者在治疗前进行基因组测序是否可行。虽然研究为未来胰腺癌治疗带来了希望,但是它到底是不是重大突破还需假以时日。

当前20%被诊断为胰腺癌的患者生存期不超过1年。有些患者对某种治疗方法并无响应,可能是因为特定肿瘤只对特定治疗方法响应。目前针对免疫系统识别和攻击癌细胞的治疗方法已经在应用和提高。但是,我们还需要更多的研究证实针对不同胰腺癌亚型的治疗方法是切实有效的。

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    2016-02-28 jetleo

    这里包括了神经内分泌肿瘤吗?

    0

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    2016-02-28 jetleo

    四种亚型:鳞状上皮肿瘤、胰腺祖细胞瘤、ADEX肿瘤和免疫原性肿瘤

    0

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    2016-02-28 jetleo

    世界范围内胰腺癌是排名第13位的常见肿瘤,且在西方国家肿瘤相关死亡中排名第4

    0

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    2016-02-26 tiffany8083

    胰腺癌的病因我也想了解呀,吃太多?

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=1753129, encodeId=6c161e53129b2, content=<a href='/topic/show?id=6a57e33772b' target=_blank style='color:#2F92EE;'>#研究发现#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=18, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=73377, encryptionId=6a57e33772b, topicName=研究发现)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=7e1736602208, createdName=hanhaisha2020, createdTime=Thu Aug 04 19:42:00 CST 2016, time=2016-08-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=66197, encodeId=f4466619e45, content=这里包括了神经内分泌肿瘤吗?, beContent=null, objectType=article, channel=null, level=null, likeNumber=102, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4bfa83595, createdName=jetleo, createdTime=Sun Feb 28 19:11:00 CST 2016, time=2016-02-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=66196, encodeId=e6fd66196a2, content=四种亚型:鳞状上皮肿瘤、胰腺祖细胞瘤、ADEX肿瘤和免疫原性肿瘤, beContent=null, objectType=article, channel=null, level=null, likeNumber=108, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4bfa83595, createdName=jetleo, createdTime=Sun Feb 28 19:09:00 CST 2016, time=2016-02-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=66195, encodeId=fbcd6619543, content=世界范围内胰腺癌是排名第13位的常见肿瘤,且在西方国家肿瘤相关死亡中排名第4, beContent=null, objectType=article, channel=null, level=null, likeNumber=117, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4bfa83595, createdName=jetleo, createdTime=Sun Feb 28 19:08:00 CST 2016, time=2016-02-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=65778, encodeId=6e2365e780c, content=胰腺癌的病因我也想了解呀,吃太多?, beContent=null, objectType=article, channel=null, level=null, likeNumber=115, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160219/IMG56C6C68249B6F6895.jpg, createdBy=4a1b1689144, createdName=tiffany8083, createdTime=Fri Feb 26 17:09:00 CST 2016, time=2016-02-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=65761, encodeId=1d5b65e61e1, content=CAR-T细胞治疗胰腺癌已初露曙光, beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://login.medsci.cn/upload/avatar/3ff956d32880c934f09cb38d2173bf88/f0dba89ce78b70994395334fac6dd9d1.jpg, createdBy=480d1617293, createdName=fangnanjing, createdTime=Fri Feb 26 14:55:00 CST 2016, time=2016-02-26, status=1, ipAttribution=)]
    2016-02-26 fangnanjing

    CAR-T细胞治疗胰腺癌已初露曙光

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