Dig Liver Dis: 慢性中性粒细胞性非过敏性鼻炎与胃食管反流病的酸暴露时间增加有关

2020-04-04 MedSci原创 MedSci原创

慢性鼻炎是一种流行性疾病,可分为过敏性(AR)和非过敏性鼻炎(NAR)。鼻细胞学可以根据炎性细胞浸润情况识别不同的NAR亚型。

背景与目标:慢性鼻炎是一种流行性疾病,可分为过敏性(AR)和非过敏性鼻炎(NAR)。鼻细胞学可以根据炎性细胞浸润情况识别不同的NAR亚型。NAR的病因尚未明确,对于NARNE(非嗜中性粒细胞过敏性鼻炎)亚型,胃食管反流病(GERD)已被认为是病因之一。本项研究的目的是评估GERD在NARNE患者中的病因作用。

方法:本研究纳入了51例具有鼻腔症状和细胞学提示NAR的患者。所有患者均进行了胃肠病学评估,进行了高分辨率食管测压和24小时pH阻抗监测。

结果:25(49%)位患者的鼻腔细胞学检查结果显示NARNE阳性。在7例NARNE患者(28%)中发现了一种病理性pH阻抗,而只有1例(4%)具有不同NAR亚型。统计分析表明,与其他NAR患者相比,NARNE中较高的酸暴露时间(AET)和较弱的鼻后引流更为常见。

结论:NARNE与更高的AET和反流次数密切相关;因此,除鼻腔细胞学检查外,还应对NARNE患者进行pH阻抗监测以判断鼻炎分型。

原始出处:
Daniele Mandolesi. Et al. Chronic non-allergic rhinitis with neutrophils is associated with higher acid exposure time: A pH-impedance monitoring study. Dig Liver Dis.2020.

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status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1437531, encodeId=7ef6143e53171, content=<a href='/topic/show?id=0e311010591a' target=_blank style='color:#2F92EE;'>#食管#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=101059, encryptionId=0e311010591a, topicName=食管)], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/aLGWoFXAyMbIu3qymFOyheQLjPSX3OUs5GmkyBlcCOwTPIeq3why9NGibxxUqYo6hcx8qZLHZFgNPnBK1yzWeOFpyg2OnWOt0/0, createdBy=fa4716, createdName=zhouqu_8, createdTime=Mon Apr 06 12:17:27 CST 2020, time=2020-04-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1571683, encodeId=bdd615e168310, content=<a href='/topic/show?id=41e33e76137' target=_blank style='color:#2F92EE;'>#反流#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, 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  8. [GetPortalCommentsPageByObjectIdResponse(id=2013266, encodeId=594e2013266f3, content=<a href='/topic/show?id=7d69598468' target=_blank style='color:#2F92EE;'>#Dis#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5984, encryptionId=7d69598468, topicName=Dis)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c689267, createdName=cmj8wellington, createdTime=Mon Oct 26 03:17:27 CST 2020, time=2020-10-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1948589, encodeId=6e201948589b0, content=<a href='/topic/show?id=87828339e7a' target=_blank style='color:#2F92EE;'>#胃食管#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=83397, encryptionId=87828339e7a, topicName=胃食管)], attachment=null, authenticateStatus=null, 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status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1437531, encodeId=7ef6143e53171, content=<a href='/topic/show?id=0e311010591a' target=_blank style='color:#2F92EE;'>#食管#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=101059, encryptionId=0e311010591a, topicName=食管)], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/aLGWoFXAyMbIu3qymFOyheQLjPSX3OUs5GmkyBlcCOwTPIeq3why9NGibxxUqYo6hcx8qZLHZFgNPnBK1yzWeOFpyg2OnWOt0/0, createdBy=fa4716, createdName=zhouqu_8, createdTime=Mon Apr 06 12:17:27 CST 2020, time=2020-04-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1571683, encodeId=bdd615e168310, content=<a href='/topic/show?id=41e33e76137' target=_blank style='color:#2F92EE;'>#反流#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=37761, encryptionId=41e33e76137, topicName=反流)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=220d15750403, createdName=feifers, createdTime=Mon Apr 06 12:17:27 CST 2020, time=2020-04-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2047243, encodeId=808c204e243f8, content=<a href='/topic/show?id=6f5294036b1' target=_blank style='color:#2F92EE;'>#过敏性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=94036, encryptionId=6f5294036b1, topicName=过敏性)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0a8e213, createdName=hongbochen, createdTime=Thu Aug 20 05:17:27 CST 2020, time=2020-08-20, status=1, ipAttribution=)]
    2020-04-06 zhouqu_8
  9. 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status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1437531, encodeId=7ef6143e53171, content=<a href='/topic/show?id=0e311010591a' target=_blank style='color:#2F92EE;'>#食管#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=101059, encryptionId=0e311010591a, topicName=食管)], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/aLGWoFXAyMbIu3qymFOyheQLjPSX3OUs5GmkyBlcCOwTPIeq3why9NGibxxUqYo6hcx8qZLHZFgNPnBK1yzWeOFpyg2OnWOt0/0, createdBy=fa4716, createdName=zhouqu_8, createdTime=Mon Apr 06 12:17:27 CST 2020, time=2020-04-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1571683, encodeId=bdd615e168310, content=<a href='/topic/show?id=41e33e76137' target=_blank style='color:#2F92EE;'>#反流#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, 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    2020-04-06 feifers
  10. 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因此,研究中的小组成员赞同:(1)当没有GERD的临床特征时,不应进行GERD治疗; (2)应使用儿科GERD指南来指导儿童患者的治疗和调查。

病例:患者反复咳嗽竟然因为胃食管反流?

患者反复咳嗽、清晨喉咙有异物感2年,打嗝会有液体反流到喉咙但没感觉反酸,晚上胸闷,感觉胸口老有东西堵着,像有痰咳不出来感觉,胃口不好,看到食物就恶心、胃痛。本地医生建议做食管测压和24小时监测。该患者有必要做相关检查吗?或者有其他方法可以诊断?

J Rheumatol:伴胃食管反流的SSc患者中患者报告结局指标的纵向评估

UCLA GIT 2.0反流量表、PROMIS反流量表和QOLRAD对变化敏感,可以被纳入未来的临床试验。

2019 CHEST指南:儿童咳嗽和胃食管反流

儿童胃食管反流 (GER) 或胃食管反流病 (GERD) 是否能导致咳嗽还存在争议,本文主要应用PICO的格式,针对儿童咳嗽和胃食管反流的管理提出指导建议。

胃食管反流16年,整年服药,仍时有不适,该怎么办

患者胃食管反流16年,24小时食管酸反流检测属于重度反流,服药后仍时有心口疼痛,该怎么办?

Sci Rep:过敏性鼻炎是胃食管反流病的一种风险因素

胃食管反流病(GERD)能够引起一些上呼吸道症状,并改变鼻咽粘膜的生理,而反过来上呼吸道疾病同样可能加剧GERD症状。长久以来,哮喘被认为是GERD的一种风险因素。根据相似的流行病学与病理生理学,哮喘和过敏性鼻炎(AR)通常被鉴定为联合气道疾病;然而,AR与GERD的相关性仍旧还没有阐明。最近,有研究人员评估了是否AR能够增加GERD的风险。研究人员从健康保险数据库中鉴定了诊断为AR的患者,时间为