Crit Care:重症监护病房机械通气患者呼吸机相关事件的流行病学特征和临床结局

2021-02-02 MedSci原创 MedSci原创

VAE在使用呼吸机超过4天的ICU患者中很常见。所有VAE与不良的临床结局高度相关,包括较长的ICU和住院时间以及更高的死亡风险。这些发现凸显了VAE监视以及开发预防VAE新策略的重要性。

呼吸机相关肺炎(VAP)是重症监护病房(ICU)患者最常见的医院获得性感染(HAI)。呼吸机相关事件(VAE)是一个更为客观的概念,它已取代了传统的VAP监视,现已在美国广泛使用。但是,在美国以外的地区使用并未推广。近日,危重病医学领域权威杂志Critical Care上发表了一篇研究文章,该研究旨在描述中国VAE的流行病学情况和临床结局。

研究人员采用中国西部ICU-HAI登记资料进行了观察性研究,纳入了2015年4月1日至2018年12月31日期间入住ICU并接受机械通气(MV)的患者。研究人员比较了伴有和不伴有VAE患者的特征和结局,并计算了所有VAE的发生率,并描述了可能发生VAP(PVAP)患者的病原体分布。

该研究共有20769名ICU患者接受了MV,研究人员总共确定了1882次呼吸机相关疾病(VAC)事件(每1000呼吸机天数有16.7次),721次感染相关的呼吸机相关并发症(IVAC)事件(每1000呼吸机天数有6.4次)和185次PVAP事件(每1000呼吸机天数有1.64次)。不同ICU的VAC发生率各不相同,在外科ICU中发生率最高(每1000呼吸机天数有23.72次)。从通气开始到第一次VAC、IVAC和PVAP的中位时间分别为5(3-8)、5(3-9)和6(4-13)天。三组患者的平均住院天数分别为28.00(17.00-43.00)、30.00(19.00-44.00)和30.00(21.00-46.00)天,均比没有VAE的患者要长(16.00 [12.00-23.00])。VAE患者的住院死亡率是非VAE患者的三倍以上。

由此可见,VAE在使用呼吸机超过4天的ICU患者中很常见。所有VAE与不良的临床结局高度相关,包括较长的ICU和住院时间以及更高的死亡风险。这些发现凸显了VAE监视以及开发预防VAE新策略的重要性。

原始出处:

Qiao He.et al.The epidemiology and clinical outcomes of ventilator-associated events among 20,769 mechanically ventilated patients at intensive care units: an observational study.Critical Care.2021.https://ccforum.biomedcentral.com/articles/10.1186/s13054-021-03484-x

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    2021-02-04 Boyinsh
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    2021-02-04 xugumin
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    2021-02-04 bioon6
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    2021-02-04 ms5000001852640370

    重中之重#高血压#

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    2021-02-03 carrotlyl

    感谢

    0

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