Genome Res:“超级细菌”揭示大肠杆菌血液感染的复杂情况

2017-10-25 佚名 生物探索

对大肠杆菌(E.coli)的首次大规模遗传学研究表明,耐药“超级细菌”并不总是与其他菌株竞争,大肠杆菌来自英国血液感染患者。 Wellcome Trust Sanger研究所及其合作者的研究表明,新型大肠杆菌经常出现,但与其他一些感染不同,耐药菌株并不是感染的主要原因。

对大肠杆菌(E.coli)的首次大规模遗传学研究表明,耐药“超级细菌”并不总是与其他菌株竞争,大肠杆菌来自英国血液感染患者。 Wellcome Trust Sanger研究所及其合作者的研究表明,新型大肠杆菌经常出现,但与其他一些感染不同,耐药菌株并不是感染的主要原因。研究人员今天在Genome Research发表了一项研究,检测了十多年来从血液感染患者中分离的大量大肠杆菌,其中一些对许多抗生素具有抗性,而另外一些则不具有抗性。研究人员发现,感染可以由超过200种大肠杆菌引起。随着时间的推移,包括多药耐药大肠杆菌在内的新菌株被发现在收集物中,但是这些菌株很快与菌群中的其他菌株达成了平衡,而不是随着时间的推移而增加。大肠杆菌是人类消化道天然携带的非常常见的细菌,但也是血液感染的主要原因。2014年英国有35,676例,通常来自于尿路或胃肠道感染的传播。研究者已经广泛研究了某些大肠杆菌菌株,如耐多种抗生素的“超级”菌株ST131。但是这项研究采用了不同的方法 - 而不仅仅着重于抗生素耐药菌株,这项研究进一步收集了1509种大肠杆菌,其大部分来自英国各地,时间超过11年。研究人员利用全基因

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    2017-10-25 15938038573红旗飘飘

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