Clinical Nutrition:补充维生素D可降低缺乏维生素D的老年人跌倒的风险

2021-10-06 MedSci原创 MedSci原创

维生素D是维持人体机体功能非常重要的营养元素之一,并且在人体生长发育中起着重要作用。特别是对于骨骼发育和新陈代谢,它是不可获得的物质。如果老人来说缺乏维生素D

      维生素D是维持人体机体功能非常重要的营养元素之一,并且在人体生长发育中起着重要作用。特别是对于骨骼发育和新陈代谢,它是不可获得的物质。如果老人来说缺乏维生素D,容易导致发育不全和骨质疏松,甚至骨折。维生素D补充剂已被广泛推荐用于预防老年人跌倒。然而,关于这种补充和跌倒风险的关联存在相当大的争议。因此,本项研究旨在对维生素D与老年人跌倒之间的风险进行了相关性分析。

 

      研究人员系统地检索了包括 PubMed 和 Embase 在内的多个文献数据库,将报告单独补充维生素 D 或与钙一起补充对跌倒发生率影响的随机临床试验 (RCT) 纳入了本项荟萃分析。提取定性和定量信息;进行随机效应模型评估,并使用I 2检验评估统计异质性。

 

      最后总共纳入了包含57867 名参与者的 31 项研究,总共报告17623 次跌倒的发生。共有 21 项单独使用维生素D的 RCT 和 10 项维生素D加钙的 RCT 被纳入荟萃分析。与安慰剂或不治疗相比, 21 项 RCT(51 984 名参与者)单独补充维生素 D(每日或间歇性剂量为 400-60 000 IU)的荟萃分析未显示维生素D的补充与跌倒风险降低相关([RR] 1.00,95% [CI] 0.95 至 1.05) 。亚组分析显示,基线血清 25(OH)D 浓度低于 50 nmoL/l 与跌倒风险降低(RR 0.77,95% CI 0.61 至 0.98)相关。

 

      本项研究证实维生素 D 和钙的组合对预防老年人跌倒有益。尽管单独补充维生素 D 对 25(OH)D 水平高于 50 nmol/L 的老年人的跌倒风险没有影响,但单独补充维生素 D 确实对25(OH)D 水平低于 50 nmol/L的老年人是有益的。

 

 

原始出处:

Yali Ling. Et al. Vitamin D supplementation reduces the risk of fall in the vitamin D deficient elderly: An updated systematic review and meta-analysis. Clinical Nutrition.2021.

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  2. [GetPortalCommentsPageByObjectIdResponse(id=1661664, encodeId=844816616641a, content=<a href='/topic/show?id=1b3c1315481' target=_blank style='color:#2F92EE;'>#nutrition#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13154, encryptionId=1b3c1315481, topicName=nutrition)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=6f0d25331316, createdName=膀胱癌, createdTime=Thu Jul 14 11:57:44 CST 2022, time=2022-07-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1060436, encodeId=540e106043647, content=有意思, beContent=null, objectType=article, channel=null, level=null, likeNumber=54, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a0a85549889, createdName=ms2000000182667314, createdTime=Thu Oct 14 13:09:11 CST 2021, time=2021-10-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1507796, encodeId=9480150e79633, content=<a href='/topic/show?id=8764484014' target=_blank style='color:#2F92EE;'>#clinical#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4840, encryptionId=8764484014, topicName=clinical)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=1ee59933733, createdName=zll0628, createdTime=Fri Oct 08 12:57:44 CST 2021, time=2021-10-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1058273, encodeId=881f10582e37b, content=涨知识, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=11e21946749, createdName=胖胖的瘦子, createdTime=Thu Oct 07 10:14:51 CST 2021, time=2021-10-07, status=1, ipAttribution=)]
    2021-10-14 ms2000000182667314

    有意思

    0

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    2021-10-08 zll0628
  4. [GetPortalCommentsPageByObjectIdResponse(id=1661664, encodeId=844816616641a, content=<a href='/topic/show?id=1b3c1315481' target=_blank style='color:#2F92EE;'>#nutrition#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13154, encryptionId=1b3c1315481, topicName=nutrition)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=6f0d25331316, createdName=膀胱癌, createdTime=Thu Jul 14 11:57:44 CST 2022, time=2022-07-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1060436, encodeId=540e106043647, content=有意思, beContent=null, objectType=article, channel=null, level=null, likeNumber=54, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a0a85549889, createdName=ms2000000182667314, createdTime=Thu Oct 14 13:09:11 CST 2021, time=2021-10-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1507796, encodeId=9480150e79633, content=<a href='/topic/show?id=8764484014' target=_blank style='color:#2F92EE;'>#clinical#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4840, encryptionId=8764484014, topicName=clinical)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=1ee59933733, createdName=zll0628, createdTime=Fri Oct 08 12:57:44 CST 2021, time=2021-10-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1058273, encodeId=881f10582e37b, content=涨知识, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=11e21946749, createdName=胖胖的瘦子, createdTime=Thu Oct 07 10:14:51 CST 2021, time=2021-10-07, status=1, ipAttribution=)]
    2021-10-07 胖胖的瘦子

    涨知识

    0

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