Diabetologia:低血糖对1型糖尿病患者工作记忆和局部脑血流量的影响

2018-04-10 MedSci MedSci原创

近日,国际杂志 《Diabetologia》上在线发表一项关于低血糖对1型糖尿病患者工作记忆和局部脑血流量影响的一项随机交叉试验的研究。这项随机交叉试验的目的是比较1型糖尿病患者低血糖期间认知功能和相关脑激活模式(血糖<3.1 mmol / l)和血糖异常的关系。 在这项患者盲法交叉研究中,共有26位1型糖尿病患者参加了两项随机实验随访:一次低血糖钳夹(PG 2.8±0.2 mmol/

近日,国际杂志 《Diabetologia》上在线发表一项关于低血糖对1型糖尿病患者工作记忆和局部脑血流量影响的一项随机交叉试验的研究。这项随机交叉试验的目的是比较1型糖尿病患者低血糖期间认知功能和相关脑激活模式(血糖<3.1 mmol / l)和血糖异常的关系。 在这项患者盲法交叉研究中,共有26位1型糖尿病患者参加了两项随机实验随访:一次低血糖钳夹(PG 2.8±0.2 mmol/l,大约持续55 min)和一次正常血糖钳夹(PG 5.5 mmol/l± 10%)。通过高胰岛素血糖钳夹维持PG水平。在使用数字符号替换测试(mDSST)和对照DSST(cDSST)的修改版本评估低血糖和血糖正常条件下的认知功能。同时,通过6次H215O正电子发射断层扫描(PET)测量预先指定的脑区域的局部脑血流量(rCBF)。 与正常血糖相比,在低血糖期间工作记忆受损,统计学显示mDSST评分较低(估计的治疗差异[ETD] -0.63 [95%CI -1.13,-0.14],p=0.014)和更长的响应时间(ETD 2.86 s [7%] [95%CI 0.67,5.05],p = 0.013)

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    2018-04-13 yfjms

    学习

    0

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    2018-04-12 chg122
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