GUT:十二指肠黏膜重铺术与血糖控制

2019-07-23 MedSci MedSci原创

研究发现,DMR联合药物可显著持久的控制患者血糖

十二指肠是治疗多种代谢相关疾病的靶点。近日研究人员评估了十二指肠黏膜重铺术(DMR)对II型糖尿病的血糖的影响。

T2D(HbA1c 59~86 mmol/mol,7.5%~10.0%)患者(BMI 24-40)在稳定口服降糖药物的基础上接受DMR治疗。降糖药物在DMR后继续治疗24周。随访期间,测定HbA1c、空腹血糖(FPG)、体重、肝转氨酶、胰岛素抵抗稳态模型评估(HOMA-IR)、不良事件(AES)和治疗满意度。

46例患者中,37例(80%)接受了完整的DMR,36例纳入分析。24例患者发生至少1例与DMR相关的AE(52%),其中81%为轻度。报告了1起SAE,未报告非预期AE。24周DMR(n=36)后,患者HbA1c(-10mmol/mol,0.9%)、FPG(-1.7)、HOMA-IR均有改善(-2.9)、体重 (-2.5 kg)以及肝转氨酶水平均有所降低。效果在12个月内维持。HbA1c的变化与轻度体重减轻无关。糖尿病治疗满意度评分显著提高。

研究发现,DMR联合药物可显著持久的控制患者血糖。

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