J Physiol:生酮饮料可改善血糖及胰岛素敏感性

2018-02-28 国际循环编辑部 国际循环

既往曾有研究报道,脂肪含量较高而碳水化合物含量较低的生酮饮食有减少癫痫发作、改善儿童行为及生活质量和减少偏头痛的健康益处。

既往曾有研究报道,脂肪含量较高而碳水化合物含量较低的生酮饮食有减少癫痫发作、改善儿童行为及生活质量和减少偏头痛的健康益处。另有研究显示,生酮饮食可改善2型糖尿病患者的预后。但是,人们对于上述作用的持久性仍存在质疑。《生理学杂志》2月15日刊中在线发表的一项有关健康志愿者的最新小型随机交叉研究表明,所谓的生酮饮料可降低血糖反应并改善胰岛素敏感性指标,且不会影响胰岛素的分泌。

研究者加拿大不列颠哥伦比亚大学奥卡纳干分校的ÉtienneMyette-Côté等共计入选20例18~35岁的健康志愿者,于过夜进食分别摄入生酮饮料或安慰剂然后行75 g OGTT试验,并在2.5小时内每15~30分钟收集一次血样。结果发现,与安慰剂相比,摄入生酮饮料时,OGTT期间的血糖反应减弱(曲线下面积减少16%,P=0.001),循环中非酯化脂肪酸(NEFA)水平及C肽增量均降低,口服葡萄糖胰岛素敏感性指数可改善11%(P=0.001)

上述结果提示,餐前应用外源性酮体补充剂生酮饮料有望降低血糖反应,可通过改善胰岛素敏感性降低血糖,可能具有防治代谢性疾病的潜能。若该研究结果能在2型糖尿病或其高危人群中得以验证,则将对代谢性疾病的防治产生重大影响。

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    2018-03-16 baoya
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    2018-03-04 yfjms

    学习

    0

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