Cell Rep:国内学者在发热伴血小板减少综合征病毒诱发炎症反应研究方面取得新进展

2020-07-28 佚名 病毒学界

研究团队通过运用临床病人样本转录组和定量蛋白质组的多维组学研究方法来揭示SFTSV感染的潜在致病机制。

近日,病毒学国家重点实验室彭珂研究组与肖庚富研究组在国际学术期刊《Cell Reports》在线发表了最新研究成果,论文题为“SFTSV Infection Induces BAK/BAX-Dependent Mitochondrial DNA Release to Trigger NLRP3 Inflammasome Activation”(发热伴血小板减少综合征病毒感染诱发BAK/BAX激活依赖的线粒体DNA释放激活NLRP3炎症小体)。

发热伴血小板减少综合征(SFTS)是一种在我国首次发现,并在东亚地区传播流行的病毒性新发传染疾病,由新型蜱传布尼亚病毒(SFTSV)感染所引起。该病起病急骤,临床病死率高(12-50%)。目前,尚无针对SFTSV的有效疫苗。因此,亟需深入解析SFTSV感染的致病机理从而为临床治疗方案的研究提供新思路。

研究团队通过运用临床病人样本转录组和定量蛋白质组的多维组学研究方法来揭示SFTSV感染的潜在致病机制。多维组学联合分析发现炎症反应与疾病进程和致死结局高度相关,而SFTSV感染诱发的线粒体损伤可能与炎症反应的发生有关。进一步的机制研究发现SFTSV感染诱发线粒体DNA的氧化,激活BAK/BAX促使氧化形式的线粒体DNA向胞质内释放,胞质内氧化形式的线粒体DNA结合并激活NLRP3炎症小体,从而导致疾病相关的炎症反应。这项研究揭示了SFTSV感染诱发线粒体DNA的氧化和胞质内释放,进一步激活NLRP3炎症小体的机制,为SFTS的临床治疗方案开发提供了理论参考。

中国科学院武汉病毒研究所助理研究员李淑芬和军事科学院军事医学研究院黎浩研究员为该文的共同第一作者,中国科学院武汉病毒研究所彭珂研究员、中国科学院武汉病毒研究所肖庚富团队的张磊砢副研究员和军事科学院军事医学研究院刘玮研究员为该文的共同通讯作者。

该工作得到了国家科技重大专项、国家重点研发计划、国家自然科学基金和中国科学院战略性先导科技专项等基金的支持。

原始出处:Shufen Li, Hao Li, Yu-Lan Zhang, et al. SFTSV Infection Induces BAK/BAX-Dependent Mitochondrial DNA Release to Trigger NLRP3 Inflammasome Activation . Cell Rep. March 31, 2020

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