Stroke:颈动脉夹层串联病变的机械取栓

2017-12-13 杨中华 脑血管病及重症文献导读

从技术上来讲,前循环串联病变采用血管内血栓切除术是一项挑战,但是HERMES工作组发现串联病变和孤立性颅内闭塞的预后类似。颈总动脉狭窄-闭塞的2个重要的病因为动脉粥样硬化和动脉夹层,这两项病因对血管内治疗后再灌注和临床预后的影响尚不清楚。


从技术上来讲,前循环串联病变采用血管血栓切除术是一项挑战,但是HERMES工作组发现串联病变和孤立性颅内闭塞的预后类似。颈总动脉狭窄-闭塞的2个重要的病因为动脉粥样硬化和动脉夹层,这两项病因对血管内治疗后再灌注和临床预后的影响尚不清楚。

为此,2017年11月来自法国的Benjamin Gory等在Stroke上公布了他们的研究结果,目的在于比较血管内治疗对动脉粥样硬化导致的串联病变和动脉夹层引起的串联病变的预后。

该研究对前瞻性收集的连续经过血管内治疗的串联病变患者个体数据进行了回顾性分析。主要终点为90天mRS 0-2,次要终点为成功再灌注(mTICI 0-2),再灌注的时间,安全性结局包括手术并发症,症状性ICH和90天死亡率。

共纳入了295例患者,65例为颈动脉夹层,230例为颈动脉粥样硬化。夹层组和动脉粥样硬化组主要终点分别为56.3%和47.6%(调整OR 1.08,95% CI 0.5 - 2.3;P = 0.85)。二级终点和安全性终点没有显著性差异。夹层组和动脉粥样硬化组平均手术时间分别为76min和67min(P = 0.24)。

最终作者认为对于前循环动脉粥样硬化性串联病变和动脉夹层性串联病变,采用血管内血栓切除术的预后没有差异。需要进一步研究证实。

原始出处:

Gory B1, Piotin M2, Haussen DC,et al.Thrombectomy in Acute Stroke With Tandem Occlusions From Dissection Versus Atherosclerotic Cause.Stroke. 2017 Nov;48(11):3145-3148. doi: 10.1161/STROKEAHA.117.018264. Epub 2017 Oct 3.

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由此可见,颈动脉迂曲与颈动脉夹层相关,这可能意味着在这些患者中颈部血管结构较为薄弱。

Stroke:颈部手法治疗或与卒中发生相关

来自罗耀拉大学医学中心的Dr. Jose Biller及其他卒中专家在Stroke杂志发表文章称,尽管仍有待确证,但包括颈部按摩在内的治疗方式或许与卒中发生相关。颈动脉的微小撕裂,也称作颈动脉夹层,是年轻及中年人群发生卒中的最常见原因之一。动脉夹层可导致血栓,血栓随血流进入脑中触发卒中。多数动脉夹层涉及创伤、拉伸或机械应力等原因,可能导致颈部过度拉伸或旋转的突然活动,如挥鞭样运动、某些运动、甚至是