J Asthma:FeNO和MMEF在预测患有或者不患有过敏性鼻炎慢性咳嗽患者中的咳嗽变异性哮喘中的诊断价值分析

2019-12-25 AlexYang MedSci原创

最近,有研究人员评估了呼出气中一氧化氮浓度(FeNO)和最大中段呼气流速(MMEF)在患有或者不患有过敏性鼻炎慢性咳嗽患者中区分咳嗽变异性哮喘(CVA)的诊断价值情况。研究总共包括了328名慢性咳嗽患者,且经历了呼吸量测试和FeNO测试。研究人员根据CVA诊断标准将患者分成了两个小组,CVA组(n=125)和NCVA(n=203)组。研究发现,FeNO和MMEF从慢性咳嗽中区分CVA的最优FeNO

最近,有研究人员评估了呼出气中一氧化氮浓度(FeNO)和最大中段呼气流速(MMEF)在患有或者不患有过敏性鼻炎慢性咳嗽患者中区分咳嗽变异性哮喘(CVA)的诊断价值情况。

研究总共包括了328名慢性咳嗽患者,且经历了呼吸量测试和FeNO测试。研究人员根据CVA诊断标准将患者分成了两个小组,CVA组(n=125)和NCVA(n=203)组。研究发现,FeNO和MMEF从慢性咳嗽中区分CVA的最优FeNO和MMEF截断值分别为24.5ppb(AUC, 0.765;敏感性,69.60%;特异性72.91%;PPV, 61.27%;NPV, 79.57%)和66.2% (AUC, 0.771;敏感性,67.20%;特异性78.33%;PPV, 65.63%;NPV, 79.50%)。FeNO组合MMEF鉴别慢性咳嗽中的CVA的最佳截断值为FeNO >22 ppb, MMEF <62.6% (AUC, 0.877)。在患有过敏性鼻炎和不患有过敏性鼻炎的患者中,区分慢性咳嗽中CVA的FeNO最优截断值分别为24.5ppb (AUC, 0.820)和33.5 ppb(AUC, 0.707)。

最后,研究人员指出,FeNO和MMEF也许在从慢性咳嗽中区分CVA中具有更大的价值。联合FeNO和MMEF比单独使用预测效果更好。另外,FeNO和MMEF的预测能力在过敏性鼻炎慢性咳嗽患者中比非过敏性鼻炎慢性咳嗽患者更好。

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    2020-06-12 skhzy
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