J Periodontal Res: 基质金属蛋白酶-7在牙周炎合并2型糖尿病中的作用

2018-07-22 MedSci MedSci原创

已经在2型糖尿病(T2DM)患者的血清样本和牙周炎患者的牙龈组织中观察到基质金属蛋白酶-7(MMP7)水平升高。本研究旨在验证MMP7在T2DM与广泛性牙周炎(GP)关系之间的作用。

已经在2型糖尿病(T2DM)患者的血清样本和牙周炎患者的牙龈组织中观察到基质金属蛋白酶-7(MMP7)水平升高。本研究旨在验证MMP7在T2DM与广泛性牙周炎(GP)关系之间的作用。

实验纳入几组患者,患T2DM(T2DM / GP,n = 11)的GP患者,患GP的全身健康患者(n = 7)以及全身和牙周健康对照组(n = 11),对患者的牙龈组织进行免疫组织化学分析,以检测MMP7表达和定位。建立计算机网络模型以确定MMP7和T2DM通路之间的相互作用。在基因敲除小鼠模型中分析MMP7对嗜中性粒细胞迁移的调节。

结果:在人牙龈组织中,与对照组相比,MMP7稳定表达的细胞在T2DM / GP患者中比例升高(P = .014)。根据计算机模拟分析,"羟基自由基"和"过氧化氢"化合物是网络中最重要的节点之一,并且在连接"葡萄糖"和"MMP7"的最短路径内。在MMP7敲除小鼠中,与野生型小鼠相比,牙龈上皮中的中性粒细胞积聚明显(P = 0.0001)。

T2DM / GP患者牙龈组织中MMP7表达升高与高血糖引起的活性氧激活有关。抑制MMP7表达导致牙龈中性粒细胞迁移受损。

原始出处:

F. Zeidan, et al. Matrix metalloproteinase‐7 in periodontitis with type 2 diabetes mellitus. Journal of Periodontal Research. 2018 June. doi: 10.1111/jre.12583

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    2018-07-22 misszhang

    谢谢MedSci提供最新的资讯

    0

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    2018-07-22 神功盖世

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