袁晶:使用CRISPR/Cas9介导的同源重组修复机制编辑疟原虫基因组

2014-09-29 佚名 生物谷

9月26日,由生物谷主办的2014基因组编辑研讨会在上海好望角大饭店隆重举行。厦门大学的袁晶教授参加了此次大会并发表了题为"Efficient Editing of Malaria Parasite Genome Using the CRIPR/Cas9 System"的精彩报告。 疟疾是由疟原虫属寄生虫感染引起的传染性疾病,全球每年约有数亿人口感染疟疾,其中上百人死亡。基于目前疟原虫对抗疟

9月26日,由生物谷主办的2014基因组编辑研讨会在上海好望角大饭店隆重举行。厦门大学的袁晶教授参加了此次大会并发表了题为"Efficient Editing of Malaria Parasite Genome Using the CRIPR/Cas9 System"的精彩报告。

疟疾是由疟原虫属寄生虫感染引起的传染性疾病,全球每年约有数亿人口感染疟疾,其中上百人死亡。基于目前疟原虫对抗疟药产生抗药性,袁晶教授致力于寻找新的抗疟靶点。袁晶教授在报告中讲到,疟原虫作为一种没有siRNA干扰系统和非同源末端连接修复机制的生物,极大地限制了人类对疟原虫基因功能的揭示。他们对于疟原虫基因组的编辑做了很多尝试,这些尝试都为疟原虫基因组编辑工作的成功积累了宝贵的意见。

之后袁晶教授重点讲述了他们使用CRISPR/Cas9系统将DNA双链断裂引入到疟原虫基因组中的各个技术关键点,他们通过同源重组的修复机制,实现了疟原虫基因组中的多个基因的不同类型修饰,包括基因删除、基因加标签和等位基因替换。他们的工作极大地促进了疟原虫生物学的研究。

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    2014-10-01 yuandd
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    2014-10-01 respect
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  7. [GetPortalCommentsPageByObjectIdResponse(id=1950090, encodeId=67b8195009075, content=<a href='/topic/show?id=f98b15504d8' target=_blank style='color:#2F92EE;'>#RISPR/Cas9#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=21, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=15504, encryptionId=f98b15504d8, topicName=RISPR/Cas9)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=e1cc90, createdName=rebeccajiejie, createdTime=Wed Apr 29 00:28:00 CST 2015, time=2015-04-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2041871, encodeId=fe4c20418e1c2, content=<a href='/topic/show?id=d289389808b' target=_blank style='color:#2F92EE;'>#同源重组#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=38980, encryptionId=d289389808b, topicName=同源重组)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=21015, createdName=heli0118, createdTime=Sat Oct 18 12:28:00 CST 2014, time=2014-10-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1275813, encodeId=150312e581391, content=<a href='/topic/show?id=755d5211a0' target=_blank style='color:#2F92EE;'>#CRISPR#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5211, encryptionId=755d5211a0, topicName=CRISPR)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=583c133, createdName=yuandd, createdTime=Wed Oct 01 00:28:00 CST 2014, time=2014-10-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1341216, encodeId=b47d1341216f6, content=<a href='/topic/show?id=e9c45226b3' target=_blank style='color:#2F92EE;'>#CRISPR/Cas9#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5226, encryptionId=e9c45226b3, topicName=CRISPR/Cas9)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=7eeb2500172, createdName=haouestc, createdTime=Wed Oct 01 00:28:00 CST 2014, time=2014-10-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1364974, encodeId=a17413649e433, content=<a href='/topic/show?id=3f66412ebd' target=_blank style='color:#2F92EE;'>#Cas9#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=19, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4127, encryptionId=3f66412ebd, topicName=Cas9)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8346212, createdName=respect, createdTime=Wed Oct 01 00:28:00 CST 2014, time=2014-10-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1387826, encodeId=8bb4138e82674, content=<a href='/topic/show?id=25ffe04313d' target=_blank style='color:#2F92EE;'>#疟原虫#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=21, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=70431, encryptionId=25ffe04313d, topicName=疟原虫)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=30bd35, createdName=一叶知秋, createdTime=Wed Oct 01 00:28:00 CST 2014, time=2014-10-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1624726, encodeId=1e9f1624e26df, content=<a href='/topic/show?id=0333412062' target=_blank style='color:#2F92EE;'>#Cas#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4120, encryptionId=0333412062, topicName=Cas)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=411420689333, createdName=yaanren, createdTime=Wed Oct 01 00:28:00 CST 2014, time=2014-10-01, status=1, ipAttribution=)]
    2014-10-01 yaanren

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