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J Mater Chem B：壳聚糖/HA复合材料或是开发组织工程支架的理想技术

2019-09-28 不详 网络

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治疗性金属离子是一类金属离子，其特征在于可以在骨组织工程中利用的特定生物学特性，从而避免了使用昂贵且可能有问题的生长因子和其他敏感生物分子。在这项工作中，我们报告了包含治疗离子的两种材料平台的成功制备和表征：铜（ii）-壳聚糖衍生物和锶取代的羟基磷灰石。这些生物材料显示出理想的离子释放曲线，可提供抗菌剂的爆发释放以及锶的持久释放，从而实现长期成骨作用。我们将铜（ii）-壳聚糖和锶-羟基磷灰石组合成

治疗性金属离子是一类金属离子，其特征在于可以在骨组织工程中利用的特定生物学特性，从而避免了使用昂贵且可能有问题的生长因子和其他敏感生物分子。在这项工作中，我们报告了包含治疗离子的两种材料平台的成功制备和表征：铜（ii）-壳聚糖衍生物和锶取代的羟基磷灰石。

这些生物材料显示出理想的离子释放曲线，可提供抗菌剂的爆发释放以及锶的持久释放，从而实现长期成骨作用。我们将铜（ii）-壳聚糖和锶-羟基磷灰石组合成冷冻干燥的复合支架。这些支架的特征是形态，机械性能和生物活性，此处定义为能够触发新型磷酸钙与生物液体接触沉积的能力。另外，使用细胞系成骨细胞进行了初步的生物学表征。

我们的结果表明，壳聚糖和羟基磷灰石与铜和锶的结合在新型支架的设计中具有巨大的潜力。壳聚糖/HA复合材料可以是开发组织工程支架的理想技术，该支架可在复合材料的两个组件中提供一系列复杂的治疗离子，从而产生自定义的生物学作用，从抗菌活性到成骨和血管生成。

原始出处：

Gritsch L, Maqbool M, et al., Chitosan/hydroxyapatite composite bone tissue engineering scaffolds with dual and decoupled therapeutic ion delivery: copper and strontium. J Mater Chem B. 2019 Sep 24. doi: 10.1039/c9tb00897g.

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    2020-01-14 ms4964546379600229

    #复合材料#

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    2019-09-30 dlwang_26703132

    #壳聚糖#

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