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Diabetes：GIP调节血管骨桥蛋白表达促进血管疾病

2017-03-25 MedSci MedSci原创

GIP骨桥蛋白动脉粥样硬化糖尿病
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葡萄糖依赖的促胰岛素多肽（GIP）除可控制血糖外，还具有胰腺外效应。瑞典学者发表题为《葡萄糖依赖的促胰岛素多肽通过内皮素-1和CREB刺激血管骨桥蛋白表达》的研究文章于著名杂志Diabetes，研究发现GIP信号在脉管系统中的意外效果。GIP通过局部释放内皮素-1和激活CREB诱导小鼠动脉中致动脉粥样硬化因子骨桥蛋白（OPN）表达。GIP增加了健康个体的血浆OPN浓度。血浆内皮素-1和OPN浓度在

葡萄糖依赖的促胰岛素多肽（GIP）除可控制血糖外，还具有胰腺外效应。瑞典学者发表题为《葡萄糖依赖的促胰岛素多肽通过内皮素-1和CREB刺激血管骨桥蛋白表达》的研究文章于著名杂志Diabetes，研究发现GIP信号在脉管系统中的意外效果。

GIP通过局部释放内皮素-1和激活CREB诱导小鼠动脉中致动脉粥样硬化因子骨桥蛋白（OPN）表达。GIP增加了健康个体的血浆OPN浓度。血浆内皮素-1和OPN浓度在严重肢体缺血患者中呈正相关。与对照受试者相比，具有心血管疾病（心肌梗塞，中风）病史的个体的空腹GIP浓度较高。 GIP受体（GIPR）和OPN mRNA水平在伴有症状（中风，短暂性脑缺血发作，一过性黑懵）的颈动脉内膜切除术患者比无症状患者高，并与不稳定性炎性斑块特征参数相关（增加的脂质积累，巨噬细胞浸润，平滑肌细胞含量降低）。虽然GIPR主要是来自人、小鼠、大鼠和猪的健康动脉内皮层，但是在培养的内皮和平滑肌细胞中都观察到其显着上调，产生"血管病样"表型。此外，GIPR基因中的共同变异体rs10423928与2型糖尿病患者的卒中风险增加相关。

原始出处：Berglund LM，Lyssenko V，et al. Glucose-Dependent Insulinotropic Polypeptide Stimulates Osteopontin Expression in the Vasculature via Endothelin-1 and CREB. Diabetes. 2016 Jan；65(1)：239-54.

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    2017-12-01 ms5439512287675881

    #BET#

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    2018-02-19 木头人513

    #Diabetes#

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    2017-08-23 ms9608593228839890

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    2017-03-26 zhouqu_8

    #血管疾病#

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    2017-03-26 xuyu

    #蛋白表达#

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=1759904, encodeId=c93d1e5990495, content=<a href='/topic/show?id=9bea33520d' target=_blank style='color:#2F92EE;'>#BET#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3352, encryptionId=9bea33520d, topicName=BET)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=9a1a37427546, createdName=ms5439512287675881, createdTime=Fri Dec 01 22:00:00 CST 2017, time=2017-12-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1901584, encodeId=dac51901584e6, content=<a href='/topic/show?id=c097591ed5' target=_blank style='color:#2F92EE;'>#Diabetes#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5917, encryptionId=c097591ed5, topicName=Diabetes)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0045169, createdName=木头人513, createdTime=Mon Feb 19 09:00:00 CST 2018, time=2018-02-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1637648, encodeId=c978163e648c1, content=<a href='/topic/show?id=afda591646' target=_blank style='color:#2F92EE;'>#DIA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5916, encryptionId=afda591646, topicName=DIA)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=987022654425, createdName=ms9608593228839890, createdTime=Wed Aug 23 11:00:00 CST 2017, time=2017-08-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1498143, encodeId=162b149814392, content=<a href='/topic/show?id=bb6f89e145a' target=_blank style='color:#2F92EE;'>#血管疾病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=89714, encryptionId=bb6f89e145a, topicName=血管疾病)], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/aLGWoFXAyMbIu3qymFOyheQLjPSX3OUs5GmkyBlcCOwTPIeq3why9NGibxxUqYo6hcx8qZLHZFgNPnBK1yzWeOFpyg2OnWOt0/0, createdBy=fa4716, createdName=zhouqu_8, createdTime=Sun Mar 26 15:00:00 CST 2017, time=2017-03-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1532646, encodeId=783a1532646f2, content=<a href='/topic/show?id=f33388695c2' target=_blank style='color:#2F92EE;'>#蛋白表达#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=46, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=88695, encryptionId=f33388695c2, topicName=蛋白表达)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=d79512374813, createdName=xuyu, createdTime=Sun Mar 26 15:00:00 CST 2017, time=2017-03-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=182629, encodeId=4ac1182629f3, content=学习了，分享了, beContent=null, objectType=article, channel=null, level=null, likeNumber=75, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=387d1660055, createdName=dhzzm, createdTime=Sat Mar 25 13:04:01 CST 2017, time=2017-03-25, status=1, ipAttribution=)]
    2017-03-25 dhzzm

    学习了，分享了

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