Radiology:心脏 MRI左心房功能评估预测心肌梗死后心血管事件的价值

2019-12-19 shaosai MedSci原创

背景:左心房(LA)功能在评估急性心肌梗死(AMI)的价值尚有争议。心脏MRI心肌特征识别(MRI-FT)是一种通过评估心肌功能来反应心房功能的一种方法。本研究旨在通过MRI-FT评估的LA功能与AMI后主要不良心血管事件(MACE)的相关性。

背景:左心房(LA)功能在评估急性心肌梗死(AMI)的价值尚有争议。心脏MRI心肌特征识别(MRI-FT)是一种通过评估心肌功能来反应心房功能的一种方法。本研究旨在通过MRI-FT评估的LA功能与AMI后主要不良心血管事件(MACE)的相关性。

本研究对多中心心脏MRI研究进行再次分析,共纳入了1235例患者,其中ST抬高心肌梗死患者795例,非ST抬高心肌梗死440例。所有患者均行心脏冠脉介入治疗。由研究人员利用MRI-FT对所有患者进行左心房功能评估,包括LA储备功能峰值收缩压(εs)、LA导管压力(εe)和LA增压泵功能活动应变(εa)。利用COX比例风险模型和ROC曲线下面积(AUC)评估LA功能与AMI12月内MACE的关系。

结果为,MACE患者的LA功能指标要比无MACE患者的差(εs = 21.2% vs 16.2%, εe = 8.8% vs 6.9%, εa = 11.8% vs 10%; P < .001)。所有左心房指标与MACE均有显着相关性(HR, εs = 0.9, εe = 0.88, εa = 0.89; P < .001)。以εs 为18.8%为最佳截断值是与预测MACE的唯一独立预测指标(HR, 0.95; P = .02)。εs 对左心室射血分数、收缩期整体纵向应变、微血管闭塞和梗死大小均有额外预测价值。

本研究表明,心脏MRI特征追踪获得的左心房峰值储备应变对不良心血管事件具有很高的预测价值以及急性心肌梗死后心脏风险指标评估具有重要作用。

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    2020-03-22 ylz8411
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    2019-12-21 sodoo
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    2019-12-19 147db991m68暂无昵称

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