Ann Rheum Dis:风湿病患者感染新冠病毒的临床特征和预后

2020-05-27 xiangting MedSci原创

感染COVID-19的风湿病患者更可能需要机械通气,但其临床特征和住院率与非风湿病患者相似。

这项研究旨在探讨风湿病患者与非风湿病患者感染2019冠状病毒(COVID-19)后临床表现和预后的差异。

在马萨诸塞州大波士顿地区的合作医疗保健系统中,对感染COVID-19的风湿病患者(通过严重急性呼吸综合征冠状病毒2 PCR确诊)进行了一项比较队列研究,按1:2的比例与年龄、性别相匹配的对照进行比较,COVID-19的诊断日期是2020年3月1日至4月8日。分析了COVID-19感染的人口学、临床特征和结局差异。主要结局是住院、重症监护、机械通气和死亡。

共确定了52例感染COVID-19的风湿病患者(平均年龄63岁;女性占69%),并将其与104例非风湿病对照进行了匹配。大多数(39,75%)风湿病患者在使用免疫抑制药物。风湿病与非风湿病患者的症状和实验室检查结果相似。风湿病与非风湿病患者的住院比例相似(23(44%)vs 42(40%),p=0.50),但风湿病患者重症监护和机械通气的比例较高(11(48%) vs 7(18%),多因素OR 3.11(95%CI 1.07-9.05)。两组的死亡率相似(3(6%)vs 4(4%),p=0.69)。

感染COVID-19的风湿病患者更可能需要机械通气,但其临床特征和住院率与非风湿病患者相似。这些发现对风湿病患者具有重要意义,但需要进一步验证。

原始出处:

Kristin M D’Silva. Clinical characteristics and outcomes of patients with coronavirus disease 2019 (COVID-19) and rheumatic disease: a comparative cohort study from a US ‘hot spot. Ann Rheum Dis. 25 May 2020

版权声明:
本网站所有内容来源注明为“梅斯医学”或“MedSci原创”的文字、图片和音视频资料,版权均属于梅斯医学所有。非经授权,任何媒体、网站或个人不得转载,授权转载时须注明来源为“梅斯医学”。其它来源的文章系转载文章,或“梅斯号”自媒体发布的文章,仅系出于传递更多信息之目的,本站仅负责审核内容合规,其内容不代表本站立场,本站不负责内容的准确性和版权。如果存在侵权、或不希望被转载的媒体或个人可与我们联系,我们将立即进行删除处理。
在此留言
评论区 (5)
#插入话题
  1. [GetPortalCommentsPageByObjectIdResponse(id=2013378, encodeId=deda20133e87f, content=<a href='/topic/show?id=7d69598468' target=_blank style='color:#2F92EE;'>#Dis#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=22, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5984, encryptionId=7d69598468, topicName=Dis)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c689267, createdName=cmj8wellington, createdTime=Fri Aug 07 16:36:53 CST 2020, time=2020-08-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1842934, encodeId=71e7184293452, content=<a href='/topic/show?id=112222886b8' target=_blank style='color:#2F92EE;'>#临床特征#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=22886, encryptionId=112222886b8, topicName=临床特征)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a12645, createdName=yeye5224612, createdTime=Fri Nov 20 04:36:53 CST 2020, time=2020-11-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1028089, encodeId=689a102808978, content=新冠肺炎,疫情何时才能消失, beContent=null, objectType=article, channel=null, level=null, likeNumber=43, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=公卫新人, createdTime=Wed May 27 16:36:53 CST 2020, time=2020-05-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=600650, encodeId=156960065021, content=不错, beContent=null, objectType=article, channel=null, level=null, likeNumber=1, replyNumber=1, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20200522/f1126cd98e1448048cb906afa4286e83/fs.jpg, createdBy=2d095296474, createdName=皮大叉, createdTime=Wed May 27 16:14:29 CST 2020, time=2020-05-27, status=1, ipAttribution=)]
  2. [GetPortalCommentsPageByObjectIdResponse(id=2013378, encodeId=deda20133e87f, content=<a href='/topic/show?id=7d69598468' target=_blank style='color:#2F92EE;'>#Dis#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=22, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5984, encryptionId=7d69598468, topicName=Dis)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c689267, createdName=cmj8wellington, createdTime=Fri Aug 07 16:36:53 CST 2020, time=2020-08-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1842934, encodeId=71e7184293452, content=<a href='/topic/show?id=112222886b8' target=_blank style='color:#2F92EE;'>#临床特征#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=22886, encryptionId=112222886b8, topicName=临床特征)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a12645, createdName=yeye5224612, createdTime=Fri Nov 20 04:36:53 CST 2020, time=2020-11-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1028089, encodeId=689a102808978, content=新冠肺炎,疫情何时才能消失, beContent=null, objectType=article, channel=null, level=null, likeNumber=43, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=公卫新人, createdTime=Wed May 27 16:36:53 CST 2020, time=2020-05-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=600650, encodeId=156960065021, content=不错, beContent=null, objectType=article, channel=null, level=null, likeNumber=1, replyNumber=1, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20200522/f1126cd98e1448048cb906afa4286e83/fs.jpg, createdBy=2d095296474, createdName=皮大叉, createdTime=Wed May 27 16:14:29 CST 2020, time=2020-05-27, status=1, ipAttribution=)]
  3. [GetPortalCommentsPageByObjectIdResponse(id=2013378, encodeId=deda20133e87f, content=<a href='/topic/show?id=7d69598468' target=_blank style='color:#2F92EE;'>#Dis#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=22, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5984, encryptionId=7d69598468, topicName=Dis)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c689267, createdName=cmj8wellington, createdTime=Fri Aug 07 16:36:53 CST 2020, time=2020-08-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1842934, encodeId=71e7184293452, content=<a href='/topic/show?id=112222886b8' target=_blank style='color:#2F92EE;'>#临床特征#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=22886, encryptionId=112222886b8, topicName=临床特征)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a12645, createdName=yeye5224612, createdTime=Fri Nov 20 04:36:53 CST 2020, time=2020-11-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1028089, encodeId=689a102808978, content=新冠肺炎,疫情何时才能消失, beContent=null, objectType=article, channel=null, level=null, likeNumber=43, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=公卫新人, createdTime=Wed May 27 16:36:53 CST 2020, time=2020-05-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=600650, encodeId=156960065021, content=不错, beContent=null, objectType=article, channel=null, level=null, likeNumber=1, replyNumber=1, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20200522/f1126cd98e1448048cb906afa4286e83/fs.jpg, createdBy=2d095296474, createdName=皮大叉, createdTime=Wed May 27 16:14:29 CST 2020, time=2020-05-27, status=1, ipAttribution=)]
    2020-05-27 公卫新人

    新冠肺炎,疫情何时才能消失

    0

  4. [GetPortalCommentsPageByObjectIdResponse(id=2013378, encodeId=deda20133e87f, content=<a href='/topic/show?id=7d69598468' target=_blank style='color:#2F92EE;'>#Dis#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=22, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5984, encryptionId=7d69598468, topicName=Dis)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c689267, createdName=cmj8wellington, createdTime=Fri Aug 07 16:36:53 CST 2020, time=2020-08-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1842934, encodeId=71e7184293452, content=<a href='/topic/show?id=112222886b8' target=_blank style='color:#2F92EE;'>#临床特征#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=22886, encryptionId=112222886b8, topicName=临床特征)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a12645, createdName=yeye5224612, createdTime=Fri Nov 20 04:36:53 CST 2020, time=2020-11-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1028089, encodeId=689a102808978, content=新冠肺炎,疫情何时才能消失, beContent=null, objectType=article, channel=null, level=null, likeNumber=43, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=公卫新人, createdTime=Wed May 27 16:36:53 CST 2020, time=2020-05-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=600650, encodeId=156960065021, content=不错, beContent=null, objectType=article, channel=null, level=null, likeNumber=1, replyNumber=1, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20200522/f1126cd98e1448048cb906afa4286e83/fs.jpg, createdBy=2d095296474, createdName=皮大叉, createdTime=Wed May 27 16:14:29 CST 2020, time=2020-05-27, status=1, ipAttribution=)]
    2020-05-27 皮大叉

    不错

    1

    展开1条回复

相关资讯

2018年风湿病学领域华人学者又有哪些新发现?

2018年我国(含港澳台)作者在风湿病领域共发文4, 737篇(文章中至少有一位华人作者),位于第二位,仅次于美国(见图1)。 图1 2018年全球风湿病领域发文数量前10名的国家 根据论文被引频次、期刊影响因子(IF)、ESI高被引/热点文献等指标,合指数综合评选出了2018年风湿病领域最受关注的华人学者发表的论文前20名,并对前10名的主要研究成果进行了编译与总结,

Semin Arthritis Rheu:tDMARDs治疗的风湿病患者COVID-19的发病率

与普通人群相比,使用tDMARDs治疗的成人和儿童风湿病患者出现COVID-19感染或更严重疾病结局的风险并未升高。

Semin Arthritis Rheu:甲氨喋呤治疗引起结核菌素试验的阳性率高:假阳性结果?

使用甲氨蝶呤与TST阳性的风险显著升高2倍相关,研究发现使用甲氨蝶呤与IGRA试验阳性之间没有统计学显著相关性。

CLIN CHEM LAB MED:单一特异性的抗dfs70抗体有助于排除抗核抗体相关的风湿病?

致密细斑点(DFS)是HEp-2细胞抗核抗体(ANA)检测结果中最常见的模式之一,主要由作为主要抗原靶点的DFS70抗体引起。最近的研究表明,由于能够更好地解释不明原因的IIF抗体阳性结果,分离的抗dfs70阳性可用于排除ANA相关的风湿病(AARD)。

Ann Rheum Dis:风湿病生物制剂使用者中的结核

重新激活和新发结核是南非所有生物制剂使用者面临的一项重大风险。筛查LTBI是一项必要的预防措施。

风湿病患者原始细胞比例增高 不一定是白血病!

42岁女患者,确诊类风湿性关节炎15年,无正规治疗,一周余前关节疼痛加剧就诊,予甲氨蝶呤+雷公藤,口服一周,自觉症状缓解不明显,关节痛加剧,入院。第一次骨髓检查一类原始细胞比例偏高。治疗10天后进行二次骨穿骨髓检查:骨髓增生极度活跃,有核细胞量明显增多,中、晚幼及杆状核粒细胞增生为主。该风湿病患者又患白血病还是另有原因?