Gut:非酒精性脂肪肝疾病与糖尿病风险之间的关系

2020-09-18 MedSci原创 MedSci原创

这项最新的荟萃分析表明,NAFLD与糖尿病风险增加约2.2倍有关。

随访研究表明非酒精性脂肪性肝病(NAFLD)与糖尿病的风险增加有关,但目前尚不明确该风险是否随NAFLD的严重程度增加而改变。近日,消化病领域权威杂志Gut上发表了一篇研究文章,研究人员对相关研究进行了荟萃分析,以量化NAFLD与糖尿病风险之间的关联程度。

研究人员使用预定义的关键字系统地检索了PubMed、Scopus和Web of Science数据库,以确定2000年1月至2020年6月期间发表的随访时间至少为1年的观察性研究,研究人员通过影像学检查或活检结果诊断NAFLD,并使用随机效应模型进行荟萃分析。

该分析纳入了33项研究,涉及501022名参与者(30.8%患有NAFLD)和27953例糖尿病患者。与没有NAFLD的患者相比,NAFLD患者发生糖尿病的风险更高(n=26项研究;随机效应HR为2.19,95%CI为1.93至2.48; I2=91.2%)。患有严重NAFLD患者也更有可能患上糖尿病(n=9项研究;随机效应HR为2.69,95%CI为2.08至3.49; I2=69%)。在整个肝纤维化的严重程度中,这种风险显著增加(n=5项研究;随机效应HR为3.42,95%CI为2.29至5.11;I2=44.6%)。所有风险均与年龄、性别、肥胖和其他常见代谢风险因素无关。敏感性分析并没有改变这些结果。漏斗图未发现任何明显的发表偏倚。

这项最新的荟萃分析表明,NAFLD与糖尿病风险增加约2.2倍有关。

原始出处:

Alessandro Mantovani.et al.Non-alcoholic fatty liver disease and risk of incident diabetes mellitus: an updated meta-analysis of 501 022 adult individuals.Gut.2020.http://dx.doi.org/10.1136/gutjnl-2020-322572

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    学习使我快乐我爱学习,学习使我快乐我爱学习,学习使我快乐我爱学习,学习使我快乐我爱学习

    0

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    2020-09-18 Jessica

    非酒精性脂肪肝疾病会增加糖尿病的发生风险

    0

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content=人体为一整体,都是相互依存的关系。, beContent=null, objectType=article, channel=null, level=null, likeNumber=64, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/Q3auHgzwzM4gCIdSaEkahCNuUWZv4iaKmqvUKHyKnBiarBM9RStQKBeV5Lh6GYYFiamdV5KlSfbLvmAgZTLtq81XA/0, createdBy=13511650672, createdName=言西早, createdTime=Fri Sep 18 12:54:48 CST 2020, time=2020-09-18, status=1, ipAttribution=)]
    2020-09-18 misszhang

    谢谢MedSci提供最新的资讯

    0

  8. 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createdName=ms8000000918729047, createdTime=Fri Sep 18 13:45:14 CST 2020, time=2020-09-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=886379, encodeId=4a198863e9d3, content=<a href='/topic/show?id=774c1248491' target=_blank style='color:#2F92EE;'>#NAFLD#</a>与<a href='/topic/show?id=4f77e665253' target=_blank style='color:#2F92EE;'>#糖尿病#</a>风险, beContent=null, objectType=article, channel=null, level=null, likeNumber=246, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12484, encryptionId=774c1248491, topicName=NAFLD), TopicDto(id=76652, encryptionId=4f77e665253, topicName=糖尿病)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220519/c2ab253484ee4527a2d4e9589a4821ac/45de9bf494a54becb2ea4369c9d11e85.jpg, createdBy=7a3710, createdName=lovetcm, createdTime=Fri Sep 18 13:35:29 CST 2020, time=2020-09-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=886369, encodeId=dff68863695c, content=人体为一整体,都是相互依存的关系。, beContent=null, objectType=article, channel=null, level=null, likeNumber=64, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/Q3auHgzwzM4gCIdSaEkahCNuUWZv4iaKmqvUKHyKnBiarBM9RStQKBeV5Lh6GYYFiamdV5KlSfbLvmAgZTLtq81XA/0, createdBy=13511650672, createdName=言西早, createdTime=Fri Sep 18 12:54:48 CST 2020, time=2020-09-18, status=1, ipAttribution=)]
    2020-09-18 ms8000000918729047

    学习

    0

  9. 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createdName=ms8000000918729047, createdTime=Fri Sep 18 13:45:14 CST 2020, time=2020-09-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=886379, encodeId=4a198863e9d3, content=<a href='/topic/show?id=774c1248491' target=_blank style='color:#2F92EE;'>#NAFLD#</a>与<a href='/topic/show?id=4f77e665253' target=_blank style='color:#2F92EE;'>#糖尿病#</a>风险, beContent=null, objectType=article, channel=null, level=null, likeNumber=246, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12484, encryptionId=774c1248491, topicName=NAFLD), TopicDto(id=76652, encryptionId=4f77e665253, topicName=糖尿病)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220519/c2ab253484ee4527a2d4e9589a4821ac/45de9bf494a54becb2ea4369c9d11e85.jpg, createdBy=7a3710, createdName=lovetcm, createdTime=Fri Sep 18 13:35:29 CST 2020, time=2020-09-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=886369, encodeId=dff68863695c, content=人体为一整体,都是相互依存的关系。, beContent=null, objectType=article, channel=null, level=null, likeNumber=64, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/Q3auHgzwzM4gCIdSaEkahCNuUWZv4iaKmqvUKHyKnBiarBM9RStQKBeV5Lh6GYYFiamdV5KlSfbLvmAgZTLtq81XA/0, createdBy=13511650672, createdName=言西早, createdTime=Fri Sep 18 12:54:48 CST 2020, time=2020-09-18, status=1, ipAttribution=)]
    2020-09-18 lovetcm
  10. 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content=人体为一整体,都是相互依存的关系。, beContent=null, objectType=article, channel=null, level=null, likeNumber=64, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/Q3auHgzwzM4gCIdSaEkahCNuUWZv4iaKmqvUKHyKnBiarBM9RStQKBeV5Lh6GYYFiamdV5KlSfbLvmAgZTLtq81XA/0, createdBy=13511650672, createdName=言西早, createdTime=Fri Sep 18 12:54:48 CST 2020, time=2020-09-18, status=1, ipAttribution=)]
    2020-09-18 言西早

    人体为一整体,都是相互依存的关系。

    0

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糖尿病患者的主要死亡原因是心脑血管疾病。随着对心脑血管疾病研究的不断深入,血管内皮功能与心脑血管疾病的关系引起研究者极大关注。

Nat Mebat:胰岛细胞皮下移植获突破,新技术成功逆转1型糖尿病

1型糖尿病是一种自身免疫性疾病,其发病机制是免疫系统错误地攻击胰岛β细胞,导致胰岛素分泌不足,机体无法维持正常的血糖水平。

JNNP:慢性炎症性脱髓鞘性多发性神经根病中糖尿病和其他并发症的发生频率及其对临床表现和治疗反应的影响

目的:确定慢性发炎性脱髓鞘性多发性神经根神经病(CIDP)中不同合并症的患病率及其对结局,治疗选择和反应的影响。

JCEM:新发1型和2型糖尿病患者炎症生物标志物与肾小球滤过率之间的关系

尽管炎症与糖尿病患者的肾功能有关,但在新诊断的糖尿病中炎症与肾功能可能的关联尚不清楚。近日,内分泌和代谢性疾病领域权威杂志Journal of Clinical Endocrinology &

JAMA Psychiatry:青少年抑郁患者接受5-羟色胺再摄取抑制剂治疗导致成年后糖尿病风险增加

儿童和青少年抑郁患者接受选择性5-羟色胺再摄取抑制剂治疗导致成年后II型糖尿病风险略微升高

Nat Med :糖尿病患者的福音,人工智能治病不比医生差

对于罹患1型糖尿病的患者来讲,强化胰岛素治疗是一种标准治疗手段,可以有效降低并发症风险。然而,他们对胰岛素剂量的需求变化极快,往往难以如此频繁地调节胰岛素泵。