JAMA:警惕处方药使用过程中的抑郁不良事件风险

2018-06-13 zhangfan MedSci原创

研究认为,处方药使用过程中抑郁不良事件发生率较高,在多药联合治疗过程中更需警惕并发抑郁症风险

在美国,近年来成年人处方药使用率不断增加,而许多药物具有潜在的致抑郁风险。近日研究人员就美国处方药使用与抑郁症不良反应之间的相关性进行了考察。

研究于2005-2014年开展,每2年为一个周期,对18岁或以上的美国成年人处方药使用情况进行了代表性横断面调查,将处方药应用导致的抑郁认定为一种潜在的不良事件。采用多变量逻辑回归分析考察处方药物使用与抑郁之间的关系,排除抗抑郁和抗高血压药物治疗人群。

总计26192名成人参与研究,平均年龄46.2岁,女性占51.1%,其中7.6%的参与者报告抑郁症状。统计发现药物治疗导致的抑郁总不良事件率为37.2%,其中2005-2006年间为35.0%,而2014-14年间上升至38.4%。2005-06年间,同时服用3种以上具有潜在抑郁风险药物的患者仅占6.9%,而2013-14年间上升至9.5%。调整分析后,服用潜在抑郁风险药物数量的增加与抑郁并发症风险相关,服用3种以上潜在抑郁风险药物患者的抑郁风险为15%,而非服药人群仅为4.7%。

研究认为,处方药使用过程中抑郁不良事件发生率较高,在多药联合治疗过程中更需警惕并发抑郁症风险。

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    2018-06-13 如风四月天

    嗯嗯.有道理

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    2018-06-13 清风拂面

    谢谢分享学习

    0

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    2018-06-13 医者仁心5538

    学习了

    0

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    2018-06-13 天地飞扬

    了解一下.谢谢分享!

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=2007395, encodeId=3002200e3957d, content=<a href='/topic/show?id=609c2048199' target=_blank style='color:#2F92EE;'>#不良事件风险#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=20481, encryptionId=609c2048199, topicName=不良事件风险)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=66962500501, createdName=yige2004, createdTime=Fri Apr 12 23:09:00 CST 2019, time=2019-04-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=323880, encodeId=4260323880e7, content=嗯嗯.有道理, beContent=null, objectType=article, channel=null, level=null, likeNumber=64, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=aaca2366983, createdName=如风四月天, createdTime=Wed Jun 13 15:41:51 CST 2018, time=2018-06-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=323875, encodeId=62883238e5b1, content=谢谢分享学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=75, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/Q3auHgzwzM4o2XVpJ6449yqDsjibydI5HnJ8MibGxNn4HZiaZib0bdfibbwoz3KQrIyN9AGxq36ZlZRNicYlPfOOWMtwgsajY6mGNFiaPclFdowjD0/0, createdBy=97bd1338592, createdName=清风拂面, createdTime=Wed Jun 13 14:34:42 CST 2018, time=2018-06-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=323861, encodeId=f93732386124, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=85, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=82311653708, createdName=医者仁心5538, createdTime=Wed Jun 13 13:33:16 CST 2018, time=2018-06-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=323855, encodeId=b831323855ef, content=了解一下.谢谢分享!, beContent=null, objectType=article, channel=null, level=null, likeNumber=70, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cdnapi.center.medsci.cn/medsci/head/2019/12/23/2f51002e1349ccda5be11c1eea1e1e60.jpg, createdBy=a22097948, createdName=天地飞扬, createdTime=Wed Jun 13 13:27:36 CST 2018, time=2018-06-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=323853, encodeId=bf403238533d, content=学习了.谢谢分享., beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/xkvRjYnJzzRJ2R0y7VhicibvkjPWHjIMmu4ZpKnE9cWAu4lVicS3uDUCfF4M4JWvrkrYfpb2KehPV0Ee29tPqyPEebBUibiaKhnvD/0, createdBy=f8412001184, createdName=惠映实验室, createdTime=Wed Jun 13 13:27:21 CST 2018, time=2018-06-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=323830, encodeId=8212323830a6, content=学了, beContent=null, objectType=article, channel=null, level=null, likeNumber=20, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTKcmgibQ4oCrK7Z6f4CvMcs4k7QUGCkhopcGxvxaBfVciadECSIwaRVttllIOEKumpEaRrq5PoOUxow/0, createdBy=e3bb2081203, createdName=哈哈869, createdTime=Wed Jun 13 11:53:23 CST 2018, time=2018-06-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=323819, encodeId=26b53238194f, content=学习了.长知识, beContent=null, objectType=article, channel=null, level=null, likeNumber=17, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220115/46bcf39c32de4aa6b45c5f9d66c8ee77/6cb4a20c55bb4b7691122f47747bfca2.jpg, createdBy=9dad1662329, createdName=1ddf0692m34(暂无匿称), createdTime=Wed Jun 13 11:17:00 CST 2018, time=2018-06-13, status=1, ipAttribution=)]
    2018-06-13 惠映实验室

    学习了.谢谢分享.

    0

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    2018-06-13 哈哈869

    学了

    0

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    2018-06-13 1ddf0692m34(暂无匿称)

    学习了.长知识

    0

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