Cancer Cell:科学家鉴别出引发儿童癌症的特殊基因

2014-08-14 佚名 生物谷

近日,刊登在国际杂志Cancer Cell上的一项研究报告中,来自西南医学中心儿童医疗研究所的研究人员通过利用小鼠模型进行研究鉴别出了一种可以引起儿童(幼鼠)癌症发生的基因,研究者表示,如果研究证实其同样适用于人类,那么这或可有效帮助科学家们开发治疗儿童肿瘤的新型靶向疗法。 文章中,研究人员Hao Zhu博士表示,我们发现一种名为Lin28b的基因在一系列的癌症儿童机体中表达,这些儿童癌症包

近日,刊登在国际杂志Cancer Cell上的一项研究报告中,来自西南医学中心儿童医疗研究所的研究人员通过利用小鼠模型进行研究鉴别出了一种可以引起儿童(幼鼠)癌症发生的基因,研究者表示,如果研究证实其同样适用于人类,那么这或可有效帮助科学家们开发治疗儿童肿瘤的新型靶向疗法。

文章中,研究人员Hao Zhu博士表示,我们发现一种名为Lin28b的基因在一系列的癌症儿童机体中表达,这些儿童癌症包括有神经细胞瘤、肾母细胞瘤、肝母细胞瘤等,Lin28b基因在胎儿机体中处于开启状态,但在成体组织中却处于关闭状态;这项研究中研究人员发现基因Lin28b的过量表达可以特殊性地引发肝母细胞瘤,而阻断Lin28b的表达则会有效阻断癌症的发展。

Lin28b是开发儿童癌症疗法一种具有潜力的靶点,因为其通常在胚胎中是表达的,因此在童年期阻断其表达或许可以在不引发任何副作用的同时特异性地阻断癌症的发展。在美国每年大约有700名儿童被诊断为神经细胞瘤,500名儿童被诊断为肾母细胞瘤,100名儿童被诊断为肝母细胞瘤;过去两年里,在达拉斯儿童医学中心已经有超过100名儿童在进行这三种类型癌症的治疗了。

此前研究发现Lin28b是干细胞及胎儿组织发育过程中的一种关键因子,于是研究者Zhu就假设是否相同的基因(即Lin28b)在特定癌症的发生过程中也扮演着重要的角色;研究人员说道,在小鼠模型中我们通过多途径来研究Lin28b基因在癌症发生过程中的作用,研究显示,Lin28b基因可以激活一系列的代谢路径,为特定癌症的发生提供一定的基础

下一步研究人员还将继续通过深入的研究来揭示,和Lin28b相关的基因是否在癌症发育的过程中发挥着着类似的作用,并且确定是否这些基因可以作为更具潜能的疗法靶点。

原始出处:

Liem H. Nguyen8, Daisy A. Robinton8, Marc T. Seligson8, Linwei Wu, Lin Li, Dinesh Rakheja, Sarah A. Comerford, Saleh Ramezani, Xiankai Sun, Monisha S. Parikh, Erin H. Yang, John T. Powers, Gen Shinoda, Samar P. Shah, Robert E. Hammer, George Q. Daley, Hao Zhu.Lin28b Is Sufficient to Drive Liver Cancer and Necessary for Its Maintenance in Murine Models.Cancer Cell doi:10.1016/j.ccr.2014.06.018

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    2015-06-07 维他命
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