Crit Care Med:早期神经肌肉电刺激可改善危重病人的功能状态

2022-05-08 MedSci原创 MedSci原创

早期NMES可促进入住ICU和出院时更好的功能状态结局。EM+NMES组的患者LOS更短,ICU-AW的发生频率更低,肌力更好。未来的研究仍有必要阐明与EM相关的治疗效果,尤其需要评估患者长期结局。

ICU患者发生住院相关并发症的风险增加。一些疾病,如ICU获得性虚弱(ICU-AW)、深静脉血栓形成、认知障碍、谵妄、院内肺炎、拔管失败和死亡,可能与长时间的制动、机械通气(MV)和镇静有关。ICU-AW可增加MW持续时间、ICU和住院时间(LOS)。重症患者第一周肌肉耗损更为明显,并受年龄、脓毒症、全身性炎症、制动、卧床休息、较长的MV和ICU住院时间的影响。

近日,危重病医学领域权威杂志Critical Care Medicine上发表了一篇研究文章,该研究旨在评估额外使用早期神经肌肉电刺激(NMES)对ICU患者早期活动(EM)方案的影响。

该随机对照试验是在巴西São Paulo大学Ribeirão Preto临床医院的ICU中完成的,纳入了139例连续就诊的在入住ICU48小时内进行MV的患者。研究人员将患者分为EM组和EM+NMES组。两组每天都接受EM治疗。EM+NMES组患者在此基础上增加NMES治疗,每周5天,每次60分钟,从入住ICU的前48小时开始,直到ICU出院。

研究人员评估了受试者的功能状态、肌力、ICU和住院时间(LOS)、谵妄频率、MV天数、死亡率和生活质量。EM+NMES组患者清醒第一天的ICU功能状态评分:22(15-26) vs. 12(8-22)(p=0.019);ICU出院人数:28例(21-33) vs. 18例(11-26)(p=0.004);出院人数:33(27-35) vs. 25(17-33)(p=0.014)明显高于EM组。通过ICU量表评估受试者的身体功能,EM+NMES组患者的功能状态更好,在ICU住院的时间更短,住院LOS显著缩短,ICU-AW的发生频率更低,整体肌力更好。

由此可见,早期NMES可促进入住ICU和出院时更好的功能状态结局。EM+NMES组的患者LOS更短,ICU-AW的发生频率更低,肌力更好。未来的研究仍有必要阐明与EM相关的治疗效果,尤其需要评估患者长期结局。

原始出处:

Campos, Débora R.et al.Early Neuromuscular Electrical Stimulation in Addition to Early Mobilization Improves Functional Status and Decreases Hospitalization Days of Critically Ill Patients.critical care medicine.2022.https://journals.lww.com/ccmjournal/Fulltext/9900/Early_Neuromuscular_Electrical_Stimulation_in.4.aspx

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    2022-05-08 ms300

    学习

    0

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    2022-05-08 小胖蟹921

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