Arthritis Rheumatol:膝关节、髋关节和手部骨关节炎的致病因素

2019-05-21 xiangting MedSci原创

BMI对负重关节的OA风险有主要的因果影响,但对手部没有影响。

骨关节炎(OA)是关节炎的最常见类型,没有治愈性疗法。这项研究目的是确定膝关节、髋关节和手部OA的因果危险因素。

研究分析了来自英国生物银行研究的384,838名无血缘关系参与者个体水平的数据。进行孟德尔随机分析以检验体重指数(BMI)、骨矿物质密度(BMD)、血清HDL-胆固醇、LDL-胆固醇、甘油三酯、2型糖尿病、收缩压(SBP)和C-反应蛋白的因果关系。蛋白质(CRP)。主要结局是使用医院诊断的OA(所有部位,n=48,431;膝关节,n=19,727;髋关节,n=11,875;手部,n=2,330)。

MR分析显示遗传决定的BMI与所有部位(每升高1SD,OR=1.57 [95%CI 1.44至1.71])、膝关节和髋关节OA存在强大的因果关联,但与手部OA无关。遗传决定的股骨颈BMD增加与所有部位(每升高1SD,OR=1.14 [95%CI 1.06至1.22])、膝关节和髋关节OA有因果关系。低SBP与所有部位OA(每降低1SD OR=1.55 [95%CI 1.29至1.87])、膝关节和髋关节OA有因果关系。没有证据表明测试的其他代谢因子或C反应蛋白与OA存在因果关系。

BMI对负重关节的OA风险有主要的因果影响,但对手部没有影响。观察到高BMD和低SBP与所有部位、膝关节和髋关节OA存在因果关系,但没有证据表明其他代谢因素或CRP与OA存在因果关系。

原始出处:

Thomas Funck‐Brentano. Causal factors for knee, hip and hand osteoarthritis: a Mendelian randomization study in the UK Biobank. Arthritis Rheumatol. 16 May 2019.

本文系梅斯医学(MedSci)原创编译整理,转载需授权!



 


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    2020-03-03 lisa438
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    2019-05-23 lmm397
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    2019-05-23 zhaojie88

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