JAHA:自发性脑出血患者房颤情况分析

2021-09-01 MedSci原创 MedSci原创

ICH患者AF患病率和OAC的使用随着时间的推移有所增加。病前使用OAC与ICH后不良结局相关,因此,在AF患者开始或继续OAC治疗之前需要更好地识别ICH风险。

心房颤动(AF)是口服抗凝剂(OAC)治疗的主要指症,但会导致自发性脑出血(ICH)。

近日,血管疾病领域权威杂志JAHA上发表了一篇研究文章,该研究旨在评估ICH患者AF患病率、时间趋势以及患者的早期功能结局和死亡。


首次ICH患者被前瞻性地纳入法国第戎的基于人群的卒中登记处(2006-2017)。研究人员使用序数和Logistic回归分析AF与ICH患者早期结局(序数修正Rankin量表评分和出院时死亡)之间的关联。

在444名ICH患者中,97名(21.9%)患者伴有AF,其中65名(14.6%)先前已知的AF患者接受了OAC治疗,13名(2.9%)患者为新诊断AF。AF患病率从17.2%(2006-2011)上升到25.8%(2012-2017)(趋势P=0.05)。研究人员观察到使用OAC治疗的AF(11.3%至17.5%,趋势P=0.09)和新诊断的AF(1.5%至4.2%,趋势P=0.11)的比例有所增加。在多变量分析中,调整发病前服用OAC后,在ICH患者中AF与改良Rankin量表评分(比值比[OR]为1.29;95%CI为0.69-2.42)或死亡(OR为0.89;95%CI为0.40-1.96)无显著相关性。尽管如此,调整后的病前OAC使用仍然与较高的死亡概率高度相关(OR为2.53;95%CI为1.11-5.78)。
 
由此可见,ICH患者AF患病率和OAC的使用随着时间的推移有所增加。病前使用OAC与ICH后不良结局相关,因此,在AF患者开始或继续OAC治疗之前需要更好地识别ICH风险,并制定AF患者发生ICH后的急性治疗和二级预防策略。

原始出处:

Amélie Gabet.et al.Atrial Fibrillation in Spontaneous Intracerebral Hemorrhage, Dijon Stroke Registry (2006–2017).JAHA.2021.https://www.ahajournals.org/doi/10.1161/JAHA.120.020040

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    2021-09-03 zhaohui6731
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    2021-09-03 sodoo
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    2021-09-02 236172785

    学习了,很有帮助

    0

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    2021-09-02 1ddeefe8m70(暂无匿称)

    很好

    0

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    2021-09-02 心介

    房颤,临床上碰到很多哦

    0

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    2021-09-02 土豆你个马铃薯

    www玉兔

    0

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