Gut:精神类药物治疗功能性消化不良是否有效?

2017-03-20 常路 环球医学编译

功能性消化不良(FD)是一种慢性胃十二指肠疾病。已经证实,FD个体具有内脏高敏感性、中枢性疼痛处理异常和情绪低落,但是精神类药物是否是该疾病的一种有效治疗手段是未知的。2017年3月,研究人员进行了一项随机对照试验(RCT)的系统评价和Meta分析对此进行分析。



功能性消化不良(FD)是一种慢性胃十二指肠疾病。已经证实,FD个体具有内脏高敏感性、中枢性疼痛处理异常和情绪低落,但是精神类药物是否是该疾病的一种有效治疗手段是未知的。2017年3月,研究人员进行了一项随机对照试验(RCT)的系统评价和Meta分析对此进行分析。

在该项研究中,研究人员检索了截止到2015年6月的Medline、Embase、Embase Classic、PsychINFO和Cochrane临床对照试验登记,检索内容为比较精神类药物与安慰剂在FD成人中效果的RCTs。为了最大限度的提高试验入组标准和最小化研究的偏倚风险,研究人员直接联系了作者。研究人员汇总了二分症状数据来获得治疗后残留症状的相对风险(RR)及其95%可信区间。

检索鉴别出2795条索引;13项RCTs(1241名患者)符合入组标准。10项试验的偏倚风险低。与安慰剂相比使用精神类药物未改善FD症状的RR为0.78(95% CI,0.68~0.91)(需要治疗数,6;95% CI,4~16)。但是,获益局限于抗精神病药物和三环类抗抑郁药。当仅考虑排除合并情绪障碍个体的研究时,获益不再。不良事件和导致停药的不良事件的总数量显着性更常见,二者产生较差结局的病例数为21。

结果表明,精神类药物是FD的有效治疗方法,但是其效果局限于抗精神病药和三环类抗抑郁药,研究其他药物的试验较少,意味着不能做出确切的有效性结论。需要更多的高质量RCTs数据来支持精神类药物在FD治疗中的使用。

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    2017-03-28 jyzxjiangqin

    精神类药物治疗功能性消化不良。

    0

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    2017-03-22 doctor_hong

    好思路也是创新啊,消化道被喻为第二大脑!

    0

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    2017-03-20 knowheart

    功能性消化不良(FD)是一种慢性胃十二指肠疾病。

    0

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