NEJM:埃罗妥珠单抗加泊马度胺和地塞米松治疗多发性骨髓瘤的疗效分析

2018-11-08 xing.T MedSci原创

由此可见,在使用来那度胺和蛋白酶体抑制剂治疗的多发性骨髓瘤患者中,接受埃罗妥珠单抗加泊马度胺和地塞米松治疗的患者的进展或死亡风险明显低于接受泊马度胺加地塞米松治疗的患者。

免疫刺激性单克隆抗体埃罗妥珠单抗加来那度胺和地塞米松已被证明对复发或难治性多发性骨髓瘤患者有效。免疫调节剂泊马度胺加地塞米松已被证明对患有来那度胺和蛋白酶体抑制剂难以治愈的多发性骨髓瘤的患者有效。

近日,顶级医学期刊NEJM上发表了一篇研究文章,研究人员将患有难治性或复发且对来那度胺和蛋白酶体抑制剂治疗无效的多发性骨髓瘤患者被随机分配接受埃罗妥珠单抗加泊马度胺和地塞米松(埃罗妥珠单抗组)或单独接受泊马度胺和地塞米松治疗(对照组)。该研究的主要终点是研究者评估的无进展生存期。

共有117名患者被随机分配到埃罗妥珠单抗组(60名患者)或对照组(57名患者)。在最短的9.1个月随访期后,埃罗妥珠单抗组的中位无进展生存期为10.3个月,对照组为4.7个月。与对照组相比,埃罗妥珠单抗组疾病进展或死亡的风险比为0.54(95%可信区间[CI]为0.34-0.86; P=0.008)。埃罗妥珠单抗组的总反应率为53%,而对照组为26%(比值比为3.25; 95%CI为1.49-7.11)。最常见的3级或4级不良事件是中性粒细胞减少症(埃罗妥珠单抗组为13%,对照组为27%)、贫血(10% vs. 20%)和高血糖(8% vs. 7%)。每组中总共65%的患者有感染。埃罗妥珠单抗组3例(5%)发生输液反应。

由此可见,在使用来那度胺和蛋白酶体抑制剂治疗的多发性骨髓瘤患者中,接受埃罗妥珠单抗加泊马度胺和地塞米松治疗的患者的进展或死亡风险明显低于接受泊马度胺加地塞米松治疗的患者。

原始出处:

Meletios A. Dimopoulos, et al.Elotuzumab plus Pomalidomide and Dexamethasone for Multiple Myeloma.NEJM.2018.https://www.nejm.org/doi/full/10.1056/NEJMoa1805762

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    2019-03-24 jml2009
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    2018-11-09 衣带渐宽

    学习

    0

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    2018-11-08 内科新手

    谢谢梅斯提供这么好的信息,学到很多

    0

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    2018-11-08 lovetcm

    单抗优势确实大

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=1889951, encodeId=b13918899515d, content=<a href='/topic/show?id=760c430895a' target=_blank style='color:#2F92EE;'>#多发性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=43089, encryptionId=760c430895a, topicName=多发性)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=04d6114, createdName=jml2009, createdTime=Sun Mar 24 05:21:00 CST 2019, time=2019-03-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=352058, encodeId=e50935205868, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmhead/Q3auHgzwzM6P57Bs8gOPaY1cQP9lIia0lmZOEXraGaoicqNToIslXDKw/0, createdBy=7a041951742, createdName=衣带渐宽, createdTime=Fri Nov 09 19:16:50 CST 2018, time=2018-11-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1647220, encodeId=c296164e220f8, content=<a href='/topic/show?id=e9bae04003f' target=_blank style='color:#2F92EE;'>#疗效分析#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=22, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=70400, encryptionId=e9bae04003f, topicName=疗效分析)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=219323401160, createdName=rebeccajiejie, createdTime=Wed Dec 05 04:21:00 CST 2018, time=2018-12-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1031966, encodeId=bf34103196686, content=谢谢梅斯提供这么好的信息,学到很多, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=内科新手, createdTime=Thu Nov 08 10:21:00 CST 2018, time=2018-11-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=351920, encodeId=866335192019, content=单抗优势确实大, beContent=null, objectType=article, channel=null, level=null, likeNumber=1, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=c4a5105539, createdName=lovetcm, createdTime=Thu Nov 08 08:53:34 CST 2018, time=2018-11-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=351915, encodeId=4b053519152b, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=52, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmhead/Q3auHgzwzM6P57Bs8gOPaY1cQP9lIia0lmZOEXraGaoicqNToIslXDKw/0, createdBy=7a041951742, createdName=衣带渐宽, createdTime=Thu Nov 08 08:28:31 CST 2018, time=2018-11-08, status=1, ipAttribution=)]
    2018-11-08 衣带渐宽

    学习

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