BMC Gastroenterology:炎症性肠病经常出现的肝胆和胰腺症状分析

2019-04-15 不详 MedSci原创

已经有文献报道,克罗恩病或溃疡性结肠炎患者易出现肝胆和胰腺疾病并发症。因此,本项研究旨在探究炎症性肠病中肝胆和胰腺表现的流行程度及其与疾病本身和所用药物的关系。

背景
已经有文献报道,克罗恩病溃疡性结肠炎患者易出现肝胆和胰腺疾病并发症。因此,本项研究旨在探究炎症性肠病中肝胆和胰腺表现的流行程度及其与疾病本身和所用药物的关系。

方法
本项研究是一项回顾性观察研究,研究人员从三级IBD转诊中心随访的患者的临床记录中收集相关数据,并做相应的分析。

结果
本项研究共纳入了602名IBD患者,平均随访时间为5.8年。2其中有20名患者进行了腹部影像学检查,55%的患者(120/220)显示有肝脏,胆道和胰腺的疾病并发症。来自肝脏,胆道和胰腺的最常见的发现或表现分别是脂肪肝(20%,44/220),胆石症(14.5%,32/220)和急性胰腺炎(0.6%,4/602)。关于肝炎病毒,三分之一的患者接受了乙肝和丙型肝炎的检测,0.5%(12/225)的患者乙型肝炎病毒表面抗原阳性,13.4%的患者感染乙型肝炎病毒(阳性抗-HBcore) 。此外,大多数患者对乙型肝炎(抗-HBs阴性)无免疫力,而3%的患者抗-HCV阳性,只有一名患者患有活动性丙型肝炎。此外,24名患者的肝脏和肝脏有药物相关的副作用。

结论
本项研究表明大约四分之一的炎症性肠病患者会出现肝胆或胰腺疾病并发症。因此,要求我们临床工作要定期监测炎症性肠病患者的肝功能。

原始出处:

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    2020-01-16 许安
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