SCI TRANSL MED:人源化的抗CD47抗体可以有效治疗儿童恶性脑部肿瘤!

2017-03-17 xing.T MedSci原创

因此,Hu5F9-G4是一个针对多个儿童中枢神经系统肿瘤潜在的安全和有效的治疗剂。

儿童恶性原发性脑部肿瘤的发病率和死亡率仍然很高,并且缺乏有效的治疗方法。巨噬细胞介导的肿瘤细胞吞噬,通过采用抗CD47抗体阻断抗吞噬CD47-SIRPα相互作用已经允许多种人类恶性肿瘤的前临床异种移植。

CD47是一种经常表达在肿瘤细胞表面的蛋白,它充当一个“不要吃我”的信号从而阻断巨噬细胞攻击肿瘤。为了攻克这一信号,使得巨噬细胞可以攻击肿瘤细胞。近日,Science Translational Medicine杂志上发表了一篇研究文章。研究人员设计了一种人源化抗体阻断CD47的信号。

这种人源化的抗CD47抗体,即Hu5F9-G4,研究人员证明了Hu5F9-G4对5种进展的和病因不同的小儿脑肿瘤有效:髓母细胞瘤(原发和转移)、非典型畸胎样横纹肌样瘤、原始神经外胚层肿瘤、小儿神经母细胞瘤和弥漫性的内在脑桥胶质瘤。研究人员证明Hu5F9-G4对来源于患者的体外和体内原位移植模型治疗有效。脑室内注射Hu5F9-G4可以进一步增强其对弥漫性髓母细胞瘤脑膜病变的疗效。值得注意的是,Hu5F9-G4对体外和体内的正常人的神经细胞效应最小,在免疫功能正常的移植瘤模型中可以重复这一现象。

因此,Hu5F9-G4是一个针对多个儿童中枢神经系统肿瘤潜在的安全和有效的治疗剂。

原始出处:

Sharareh Gholamin,et al.Disrupting the CD47-SIRPα anti-phagocytic axis by a humanized anti-CD47 antibody is an efficacious treatment for malignant pediatric brain tumors.Science Translational Medicine  15 Mar 2017:DOI: 10.1126/scitranslmed.aaf2968

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    2017-08-21 bsmagic9140
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    2017-12-10 qidongfanjian
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    2017-03-28 葫芦糊涂

    啦啦啦萝莉控阿卡丽神秘商店

    0

  4. [GetPortalCommentsPageByObjectIdResponse(id=1656754, encodeId=cc571656e5485, content=<a href='/topic/show?id=3ca31e71903' target=_blank style='color:#2F92EE;'>#TRA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=22, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=17719, encryptionId=3ca31e71903, topicName=TRA)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=757b24868428, createdName=bsmagic9140, createdTime=Mon Aug 21 05:20:00 CST 2017, time=2017-08-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1864218, encodeId=d830186421836, content=<a href='/topic/show?id=f930432538' target=_blank style='color:#2F92EE;'>#CD4#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4325, encryptionId=f930432538, topicName=CD4)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b09892, createdName=qidongfanjian, createdTime=Sun Dec 10 06:20:00 CST 2017, time=2017-12-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=183173, encodeId=730f1831e338, content=啦啦啦萝莉控阿卡丽神秘商店, beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=38b31934560, createdName=葫芦糊涂, createdTime=Tue Mar 28 07:20:52 CST 2017, time=2017-03-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=183012, encodeId=80871830120f, content=非常完美居然阿里来了, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=38b31934560, createdName=葫芦糊涂, createdTime=Mon Mar 27 08:44:20 CST 2017, time=2017-03-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2067207, encodeId=b02b206e207d7, content=<a href='/topic/show?id=d0841e75535' target=_blank style='color:#2F92EE;'>#Transl#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=22, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=17755, encryptionId=d0841e75535, topicName=Transl)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdqq.qlogo.cn/qqapp/101173734/363C99735735B7F4CB11D5F78F580525/100, createdBy=aab22500211, createdName=ms3025846204744509, createdTime=Thu May 18 04:20:00 CST 2017, time=2017-05-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=182603, encodeId=9dcb1826033e, content=考虑考虑牟利, beContent=null, objectType=article, channel=null, level=null, likeNumber=57, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=38b31934560, createdName=葫芦糊涂, createdTime=Sat Mar 25 09:04:25 CST 2017, time=2017-03-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=182360, encodeId=eb2a1823602b, content=阿菊KTV了阿卡丽, beContent=null, objectType=article, channel=null, level=null, likeNumber=72, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=38b31934560, createdName=葫芦糊涂, createdTime=Fri Mar 24 08:20:42 CST 2017, time=2017-03-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=182121, encodeId=ef34182121f2, content=hhgfrrdssfgg, beContent=null, objectType=article, channel=null, level=null, likeNumber=73, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=38b31934560, createdName=葫芦糊涂, createdTime=Thu Mar 23 08:54:07 CST 2017, time=2017-03-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=181855, encodeId=aaed181855e7, content=胡图图啦啦啦结局, beContent=null, objectType=article, channel=null, level=null, likeNumber=20, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=38b31934560, createdName=葫芦糊涂, createdTime=Wed Mar 22 07:54:33 CST 2017, time=2017-03-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=181624, encodeId=59a3181624f5, content=近距离奎, beContent=null, objectType=article, channel=null, level=null, likeNumber=18, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=38b31934560, createdName=葫芦糊涂, createdTime=Tue Mar 21 08:56:54 CST 2017, time=2017-03-21, status=1, ipAttribution=)]
    2017-03-27 葫芦糊涂

    非常完美居然阿里来了

    0

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  6. [GetPortalCommentsPageByObjectIdResponse(id=1656754, encodeId=cc571656e5485, content=<a href='/topic/show?id=3ca31e71903' target=_blank style='color:#2F92EE;'>#TRA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=22, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=17719, encryptionId=3ca31e71903, topicName=TRA)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=757b24868428, createdName=bsmagic9140, createdTime=Mon Aug 21 05:20:00 CST 2017, time=2017-08-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1864218, encodeId=d830186421836, content=<a href='/topic/show?id=f930432538' target=_blank style='color:#2F92EE;'>#CD4#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4325, encryptionId=f930432538, topicName=CD4)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b09892, createdName=qidongfanjian, createdTime=Sun Dec 10 06:20:00 CST 2017, time=2017-12-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=183173, encodeId=730f1831e338, content=啦啦啦萝莉控阿卡丽神秘商店, beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=38b31934560, createdName=葫芦糊涂, createdTime=Tue Mar 28 07:20:52 CST 2017, time=2017-03-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=183012, encodeId=80871830120f, content=非常完美居然阿里来了, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=38b31934560, createdName=葫芦糊涂, createdTime=Mon Mar 27 08:44:20 CST 2017, time=2017-03-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2067207, encodeId=b02b206e207d7, content=<a href='/topic/show?id=d0841e75535' target=_blank style='color:#2F92EE;'>#Transl#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=22, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=17755, encryptionId=d0841e75535, topicName=Transl)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdqq.qlogo.cn/qqapp/101173734/363C99735735B7F4CB11D5F78F580525/100, createdBy=aab22500211, createdName=ms3025846204744509, createdTime=Thu May 18 04:20:00 CST 2017, time=2017-05-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=182603, encodeId=9dcb1826033e, content=考虑考虑牟利, beContent=null, objectType=article, channel=null, level=null, likeNumber=57, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=38b31934560, createdName=葫芦糊涂, createdTime=Sat Mar 25 09:04:25 CST 2017, time=2017-03-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=182360, encodeId=eb2a1823602b, content=阿菊KTV了阿卡丽, beContent=null, objectType=article, channel=null, level=null, likeNumber=72, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=38b31934560, createdName=葫芦糊涂, createdTime=Fri Mar 24 08:20:42 CST 2017, time=2017-03-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=182121, encodeId=ef34182121f2, content=hhgfrrdssfgg, beContent=null, objectType=article, channel=null, level=null, likeNumber=73, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=38b31934560, createdName=葫芦糊涂, createdTime=Thu Mar 23 08:54:07 CST 2017, time=2017-03-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=181855, encodeId=aaed181855e7, content=胡图图啦啦啦结局, beContent=null, objectType=article, channel=null, level=null, likeNumber=20, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=38b31934560, createdName=葫芦糊涂, createdTime=Wed Mar 22 07:54:33 CST 2017, time=2017-03-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=181624, encodeId=59a3181624f5, content=近距离奎, beContent=null, objectType=article, channel=null, level=null, likeNumber=18, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=38b31934560, createdName=葫芦糊涂, createdTime=Tue Mar 21 08:56:54 CST 2017, time=2017-03-21, status=1, ipAttribution=)]
    2017-03-25 葫芦糊涂

    考虑考虑牟利

    0

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    2017-03-24 葫芦糊涂

    阿菊KTV了阿卡丽

    0

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    2017-03-23 葫芦糊涂

    hhgfrrdssfgg

    0

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    2017-03-22 葫芦糊涂

    胡图图啦啦啦结局

    0

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    2017-03-21 葫芦糊涂

    近距离奎

    0

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