Arthritis Rheumatol:痛风和血清尿酸与心血管结局的关联

2019-06-27 xiangting MedSci原创

伴和不伴痛风的患者ACS后的存活率相近。痛风患者因心衰再入院的风险高,并且住院时间长。

这项研究旨在确定痛风和血清尿酸(SU)是否与心血管疾病患者的死亡风险升高、任何心血管事件或心衰的首次再入院时间相关。

急性冠脉综合征(ACS)患者被纳入冠脉疾病队列研究。从指数住院期间收集临床数据,并在出院后收集临床、超声心动图和生化数据。通过自我报告或使用降尿酸治疗或秋水仙碱,并且病历有痛风证据来定义痛风。主要终点是全因死亡率、因心脏缺血事件或心衰再入院的时间。

1514名参与者的数据可用。随访期间,53/160名(33.1%)痛风患者,298/1354名(22.1%)非痛风患者死亡。在调整了已知与死亡率相关的其他因素之后,没有痛风特异性的死亡风险升高(调整后的HR为0.98(95%CI 0.69-1.38))。与非痛风患者相比,痛风患者心衰的再入院时间明显更短(调整后HR 1.46(95%CI 1.02-1.97))。无论是否有痛风,随着SU升高,死亡风险和因心血管事件或心衰再入院的风险均升高。

伴和不伴痛风的患者ACS后的存活率相近。痛风患者因心衰再入院的风险高,并且住院时间长。这些事件的风险与SU并行升高。

原始出处:

Lisa K Stamp. Associations of gout and baseline serum urate with cardiovascular outcomes: analysis of the Coronary Disease Cohort Study. Arthritis Rheumatol. 04 June 2019.

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