Am J Gastroenterol:结肠粘膜炎症并非憩室病的致病因素

2019-03-10 zhangfan MedSci原创

研究认为,憩室病与结肠粘膜炎症无关,症状性结肠憩室病的病因需要进一步研究。

低度慢性炎症被认为是非复杂无症状或有症状肠憩室病的致病因素,然而上述结伦缺乏以人口为基础的研究证据。近日研究人员在组织学和血清学基础上考察了憩室病与结肠炎症的相关性。

254名患者参与研究,接受结肠镜、结肠组织炎症标志物和血清C反应蛋白水平考察,采用逻辑回归和线性回归模型比较有无肠憩室病患者间的差异。

组间基本信息(如年龄、性别、体重指数、吸烟以及抗生素使用)无显著差异。肠憩室病患者报告的腹痛和腹泻症状多于对照组。组间平均C反应蛋白水平无显著差异。除肠憩室病组盲肠淋巴聚合体数目增加以外,在组织学上没有发现憩室病与炎症标志物之间的其他关联。与无症状对照组相比,血清学或黏膜炎症与症状性腹泻或腹痛无关。

研究认为,憩室病与结肠粘膜炎症无关,症状性结肠憩室病的病因需要进一步研究。

原始出处:


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    2019-06-03 guoyibin
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    2019-12-23 许安
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    2019-03-12 zutt
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