Arthritis Rheumatol:纤维肌痛中颈髓静息状态活动的改变

2018-10-06 xiangting MedSci原创

研究结果表明,纤维肌痛中腹侧和背侧颈髓的活动不平衡。

传入和中枢神经调节的改变被认为有助于改善纤维肌痛的症状,并且这些过程在脊髓内会聚。这项研究假设,使用颈髓静息状态功能性磁共振成像(rs-fMRI),可以观察到纤维肌痛中频率依赖性活动的改变。

对纤维肌痛患者和健康对照进行颈髓rs-fMRI检查。分析了频率0.01-0.198Hz和频率子带的低频振荡功率、低频波动幅度(ALFF)指标,以确定纤维肌痛的区域和频率特异性改变。还分析了功能连接和图表指标。

与对照组相比,在纤维肌痛患者中观察到频率0.01-0.198Hz和所有子带的腹侧颈髓平均ALFF较大,而背侧平均ALFF较小(p<0.05,未校正)。另外,在纤维肌痛患者中观察到频率0.01-0.198Hz和子带频率0.073-0.198Hz的右背侧象限平均ALFF较小(p<0.05,已校正)。区域性平均ALFF与疼痛无关,但区域性平均ALFF较小与患者的疲劳相关(r=0.763,p=0.001)。组间的功能连接和图表指标相似。

研究结果表明,纤维肌痛中腹侧和背侧颈髓的活动不平衡。腹侧神经活动增加和背侧神经活动减少反映了存在中枢致敏,并导致了纤维肌痛的疲劳和其他身体症状。

原始出处:
Katherine T Martucci. Altered Cervical Spinal Cord Resting State Activity in Fibromyalgia. Arthritis Rheumatol. 03 October 2018.

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    2018-10-09 wxl882001

    学习一下

    0

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    2018-10-08 zhaojie88
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    2018-10-07 秀红

    学习了

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=1972546, encodeId=2fde19e2546fc, content=<a href='/topic/show?id=8a6a2e8839' target=_blank style='color:#2F92EE;'>#Arthritis#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2788, encryptionId=8a6a2e8839, topicName=Arthritis)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTIibticIBly5jCSic5ZElW4He3rO4DMpUHUFaFX57OicNMnzckWaicBNeStwugWHFCuOdicoakApM4HGmtw/132, createdBy=f8672500006, createdName=ms6390871039024434, createdTime=Thu Jun 20 20:05:00 CST 2019, time=2019-06-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2078412, encodeId=30b420e84125a, content=<a href='/topic/show?id=3b04990841c' target=_blank style='color:#2F92EE;'>#静息状态#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=99084, encryptionId=3b04990841c, topicName=静息状态)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=08e964, createdName=drwjr, createdTime=Thu Mar 07 05:05:00 CST 2019, time=2019-03-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=348639, encodeId=4ed834863940, content=学习一下, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6KcicAVC1MwuOgo3iaicb1Imgk1yIfnvr6oXzibcAFB6puAyNJXbzWhNuLqaFYBVRWjh7rghkvFLPxMAfD5ib3nXwVD/0, createdBy=bed21972958, createdName=wxl882001, createdTime=Tue Oct 09 17:51:19 CST 2018, time=2018-10-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1356948, encodeId=c80d1356948c5, content=<a href='/topic/show?id=b0702e84b9' target=_blank style='color:#2F92EE;'>#ART#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2784, encryptionId=b0702e84b9, topicName=ART)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=zhaojie88, createdTime=Mon Oct 08 02:05:00 CST 2018, time=2018-10-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=348286, encodeId=520234828673, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2018/01/15/8213228fe923915543544ad3da7e1c64.jpg, createdBy=6bd82014262, createdName=秀红, createdTime=Sun Oct 07 04:46:47 CST 2018, time=2018-10-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=348196, encodeId=fcf034819646, content=嗯嗯,学习了。, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2018/07/16/3b24606172648eea459125cb74754afe.jpg, createdBy=6c022216608, createdName=liumin1987, createdTime=Sat Oct 06 11:42:59 CST 2018, time=2018-10-06, status=1, ipAttribution=)]
    2018-10-06 liumin1987

    嗯嗯,学习了。

    0

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