Alzheimers Dementia:随访2万人20年,痴呆诊断前后,医疗开支情况如何?

2022-03-15 Freeman MedSci原创

早在正式诊断痴呆症前10年就出现了超额的医疗费用

目前,痴呆症是导致死亡和残疾的主要原因之一,给痴呆症疾病(以下简称 "痴呆症")患者、其家人和社会带来了巨大的负担。由于65岁以后患痴呆症的风险每5年翻一番,而且许多国家的老年人口在不断增长,因此患病率和相关的医疗费用也可能在加速增长。2018年,全世界估计有>5000万痴呆症患者,预计到2050年,这一数字将上升到>1.52亿。

随着痴呆症发病率的上升,政策越来越有动力去考虑经济学家的观点,并更准确地考虑是什么在驱动成本。决策者需要可靠的、最新的、关于痴呆症后果的信息来规划服务和制定适当的政策。此外,了解解释痴呆症这些后果的基本因素也有助于确定和评估具体的干预方案。

据估计,全球每年的痴呆症成本为1万亿美元。对医疗费用的分析可以提供与特定疾病相关的护理负担的来源和程度的有用信息。有几项研究估计了不同国家环境下的痴呆症成本。例如,最近对26项研究的系统回顾估计,欧洲和美国的痴呆症患者每人每年的成本分别为32,507欧元和43,899欧元(2015价格年)。

然而,许多研究都缺乏对比组--即认知健康的人群,因此很难衡量痴呆症的超额医疗费用。此外,审查中的大多数研究都是基于横断面数据,没有提供关于痴呆症费用随时间发展的信息。

藉此,瑞典隆德大学的Sofie Persson等人, 探究了17年内归因于痴呆症的医疗费用,并提供诊断前十年的费用洞察,估计诊断时费用的增加程度,并检查诊断后6年的费用发展趋势。由于以前的研究表明,痴呆症的认知障碍可能在诊断前18年就已经形成。

核心假设是,在痴呆症正式诊断前几年就可以观察到医疗费用的增加。

他们利用瑞典南部被诊断为痴呆症患者(2010-2016年)的行政登记数据(n = 21,184),以及一个没有痴呆症的对比组,使用纵向回归分析对17年的医疗费用进行了研究。

他们发现:痴呆组每人每年的平均医疗费用在诊断前一直较高(10年前,瑞典克朗(SEK)2063,P < .005;1年前。SEK8166,P < .005)。

在诊断时,保健费用是其两倍多(44,410瑞典克朗,P < .005)。

诊断后4至6年,与比较者相比,费用没有明显差异。

该研究的重要意义在于发现了:早在正式诊断痴呆症前10年就出现了超额的医疗费用,虽然诊断后费用激增,但4年后的医疗费用并无不同。这些发现对目前公认的痴呆症成本假设提出质疑。


原文出处:
Persson S, Saha S, Gerdtham U, Toresson H, Trépel D, Jarl J. Healthcare costs of dementia diseases before, during and after diagnosis: Longitudinal analysis of 17 years of Swedish register data. Alzheimer’s & Dementia. Published online February 21, 2022:alz.12619. doi:10.1002/alz.12619

 

版权声明:
本网站所有内容来源注明为“梅斯医学”或“MedSci原创”的文字、图片和音视频资料,版权均属于梅斯医学所有。非经授权,任何媒体、网站或个人不得转载,授权转载时须注明来源为“梅斯医学”。其它来源的文章系转载文章,或“梅斯号”自媒体发布的文章,仅系出于传递更多信息之目的,本站仅负责审核内容合规,其内容不代表本站立场,本站不负责内容的准确性和版权。如果存在侵权、或不希望被转载的媒体或个人可与我们联系,我们将立即进行删除处理。
在此留言
评论区 (7)
#插入话题
  1. [GetPortalCommentsPageByObjectIdResponse(id=1718131, encodeId=12521e18131cf, content=<a href='/topic/show?id=8f0658433a' target=_blank style='color:#2F92EE;'>#dementia#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5843, encryptionId=8f0658433a, topicName=dementia)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=307e32501717, createdName=linlin2323, createdTime=Fri Oct 14 07:53:15 CST 2022, time=2022-10-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1779829, encodeId=cb431e798290a, content=<a href='/topic/show?id=51b4238909' target=_blank style='color:#2F92EE;'>#alzheimers#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2389, encryptionId=51b4238909, topicName=alzheimers)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=930e243, createdName=dingxiaobo, createdTime=Fri Nov 18 06:53:15 CST 2022, time=2022-11-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1878490, encodeId=d5bb18e849020, content=<a href='/topic/show?id=c157696175' target=_blank style='color:#2F92EE;'>#ERS#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=6961, encryptionId=c157696175, topicName=ERS)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e93e105, createdName=anminleiryan, createdTime=Sat Dec 10 19:53:15 CST 2022, time=2022-12-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1202707, encodeId=ddc01202e078b, content=随访, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210511/ddebdec707734c8390a07bd0c1048717/cc11caf5d607430e9f4ca556fed68ab1.jpg, createdBy=2c4d5497888, createdName=梅斯助教, createdTime=Tue Mar 15 10:51:53 CST 2022, time=2022-03-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1202705, encodeId=b9d61202e05ec, content=<a href='/topic/show?id=1ff01043052c' target=_blank style='color:#2F92EE;'>#谢谢#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=104305, encryptionId=1ff01043052c, topicName=谢谢)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210511/ddebdec707734c8390a07bd0c1048717/cc11caf5d607430e9f4ca556fed68ab1.jpg, createdBy=2c4d5497888, createdName=梅斯助教, createdTime=Tue Mar 15 10:51:09 CST 2022, time=2022-03-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1338551, encodeId=3bce1338551f2, content=<a href='/topic/show?id=767711566a9' target=_blank style='color:#2F92EE;'>#MERS#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11566, encryptionId=767711566a9, topicName=MERS)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdwx.qlogo.cn/mmopen/vi_32/71tKRib0PibveVjnEa7tPLMaCzoKicFlKSEOzRTGf4wNvDV54kJyNx1ott1D5Xp5gRu7IwUia77oN0YFdffvQMu6Ug/132, createdBy=9e302500146, createdName=ms49895894946433513521, createdTime=Fri Mar 11 08:53:15 CST 2022, time=2022-03-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1246675, encodeId=822612466e5da, content=老年性痴呆,未来还是希望借助神经电生理吧,也许更为有效!, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=neuro.Dr, createdTime=Wed Mar 09 20:53:15 CST 2022, time=2022-03-09, status=1, ipAttribution=)]
  2. [GetPortalCommentsPageByObjectIdResponse(id=1718131, encodeId=12521e18131cf, content=<a href='/topic/show?id=8f0658433a' target=_blank style='color:#2F92EE;'>#dementia#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5843, encryptionId=8f0658433a, topicName=dementia)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=307e32501717, createdName=linlin2323, createdTime=Fri Oct 14 07:53:15 CST 2022, time=2022-10-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1779829, encodeId=cb431e798290a, content=<a href='/topic/show?id=51b4238909' target=_blank style='color:#2F92EE;'>#alzheimers#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2389, encryptionId=51b4238909, topicName=alzheimers)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=930e243, createdName=dingxiaobo, createdTime=Fri Nov 18 06:53:15 CST 2022, time=2022-11-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1878490, encodeId=d5bb18e849020, content=<a href='/topic/show?id=c157696175' target=_blank style='color:#2F92EE;'>#ERS#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=6961, encryptionId=c157696175, topicName=ERS)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e93e105, createdName=anminleiryan, createdTime=Sat Dec 10 19:53:15 CST 2022, time=2022-12-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1202707, encodeId=ddc01202e078b, content=随访, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210511/ddebdec707734c8390a07bd0c1048717/cc11caf5d607430e9f4ca556fed68ab1.jpg, createdBy=2c4d5497888, createdName=梅斯助教, createdTime=Tue Mar 15 10:51:53 CST 2022, time=2022-03-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1202705, encodeId=b9d61202e05ec, content=<a href='/topic/show?id=1ff01043052c' target=_blank style='color:#2F92EE;'>#谢谢#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=104305, encryptionId=1ff01043052c, topicName=谢谢)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210511/ddebdec707734c8390a07bd0c1048717/cc11caf5d607430e9f4ca556fed68ab1.jpg, createdBy=2c4d5497888, createdName=梅斯助教, createdTime=Tue Mar 15 10:51:09 CST 2022, time=2022-03-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1338551, encodeId=3bce1338551f2, content=<a href='/topic/show?id=767711566a9' target=_blank style='color:#2F92EE;'>#MERS#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11566, encryptionId=767711566a9, topicName=MERS)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdwx.qlogo.cn/mmopen/vi_32/71tKRib0PibveVjnEa7tPLMaCzoKicFlKSEOzRTGf4wNvDV54kJyNx1ott1D5Xp5gRu7IwUia77oN0YFdffvQMu6Ug/132, createdBy=9e302500146, createdName=ms49895894946433513521, createdTime=Fri Mar 11 08:53:15 CST 2022, time=2022-03-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1246675, encodeId=822612466e5da, content=老年性痴呆,未来还是希望借助神经电生理吧,也许更为有效!, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=neuro.Dr, createdTime=Wed Mar 09 20:53:15 CST 2022, time=2022-03-09, status=1, ipAttribution=)]
  3. [GetPortalCommentsPageByObjectIdResponse(id=1718131, encodeId=12521e18131cf, content=<a href='/topic/show?id=8f0658433a' target=_blank style='color:#2F92EE;'>#dementia#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5843, encryptionId=8f0658433a, topicName=dementia)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=307e32501717, createdName=linlin2323, createdTime=Fri Oct 14 07:53:15 CST 2022, time=2022-10-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1779829, encodeId=cb431e798290a, content=<a href='/topic/show?id=51b4238909' target=_blank style='color:#2F92EE;'>#alzheimers#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2389, encryptionId=51b4238909, topicName=alzheimers)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=930e243, createdName=dingxiaobo, createdTime=Fri Nov 18 06:53:15 CST 2022, time=2022-11-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1878490, encodeId=d5bb18e849020, content=<a href='/topic/show?id=c157696175' target=_blank style='color:#2F92EE;'>#ERS#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=6961, encryptionId=c157696175, topicName=ERS)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e93e105, createdName=anminleiryan, createdTime=Sat Dec 10 19:53:15 CST 2022, time=2022-12-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1202707, encodeId=ddc01202e078b, content=随访, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210511/ddebdec707734c8390a07bd0c1048717/cc11caf5d607430e9f4ca556fed68ab1.jpg, createdBy=2c4d5497888, createdName=梅斯助教, createdTime=Tue Mar 15 10:51:53 CST 2022, time=2022-03-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1202705, encodeId=b9d61202e05ec, content=<a href='/topic/show?id=1ff01043052c' target=_blank style='color:#2F92EE;'>#谢谢#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=104305, encryptionId=1ff01043052c, topicName=谢谢)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210511/ddebdec707734c8390a07bd0c1048717/cc11caf5d607430e9f4ca556fed68ab1.jpg, createdBy=2c4d5497888, createdName=梅斯助教, createdTime=Tue Mar 15 10:51:09 CST 2022, time=2022-03-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1338551, encodeId=3bce1338551f2, content=<a href='/topic/show?id=767711566a9' target=_blank style='color:#2F92EE;'>#MERS#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11566, encryptionId=767711566a9, topicName=MERS)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdwx.qlogo.cn/mmopen/vi_32/71tKRib0PibveVjnEa7tPLMaCzoKicFlKSEOzRTGf4wNvDV54kJyNx1ott1D5Xp5gRu7IwUia77oN0YFdffvQMu6Ug/132, createdBy=9e302500146, createdName=ms49895894946433513521, createdTime=Fri Mar 11 08:53:15 CST 2022, time=2022-03-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1246675, encodeId=822612466e5da, content=老年性痴呆,未来还是希望借助神经电生理吧,也许更为有效!, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=neuro.Dr, createdTime=Wed Mar 09 20:53:15 CST 2022, time=2022-03-09, status=1, ipAttribution=)]
    2022-12-10 anminleiryan
  4. [GetPortalCommentsPageByObjectIdResponse(id=1718131, encodeId=12521e18131cf, content=<a href='/topic/show?id=8f0658433a' target=_blank style='color:#2F92EE;'>#dementia#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5843, encryptionId=8f0658433a, topicName=dementia)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=307e32501717, createdName=linlin2323, createdTime=Fri Oct 14 07:53:15 CST 2022, time=2022-10-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1779829, encodeId=cb431e798290a, content=<a href='/topic/show?id=51b4238909' target=_blank style='color:#2F92EE;'>#alzheimers#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2389, encryptionId=51b4238909, topicName=alzheimers)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=930e243, createdName=dingxiaobo, createdTime=Fri Nov 18 06:53:15 CST 2022, time=2022-11-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1878490, encodeId=d5bb18e849020, content=<a href='/topic/show?id=c157696175' target=_blank style='color:#2F92EE;'>#ERS#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=6961, encryptionId=c157696175, topicName=ERS)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e93e105, createdName=anminleiryan, createdTime=Sat Dec 10 19:53:15 CST 2022, time=2022-12-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1202707, encodeId=ddc01202e078b, content=随访, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210511/ddebdec707734c8390a07bd0c1048717/cc11caf5d607430e9f4ca556fed68ab1.jpg, createdBy=2c4d5497888, createdName=梅斯助教, createdTime=Tue Mar 15 10:51:53 CST 2022, time=2022-03-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1202705, encodeId=b9d61202e05ec, content=<a href='/topic/show?id=1ff01043052c' target=_blank style='color:#2F92EE;'>#谢谢#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=104305, encryptionId=1ff01043052c, topicName=谢谢)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210511/ddebdec707734c8390a07bd0c1048717/cc11caf5d607430e9f4ca556fed68ab1.jpg, createdBy=2c4d5497888, createdName=梅斯助教, createdTime=Tue Mar 15 10:51:09 CST 2022, time=2022-03-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1338551, encodeId=3bce1338551f2, content=<a href='/topic/show?id=767711566a9' target=_blank style='color:#2F92EE;'>#MERS#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11566, encryptionId=767711566a9, topicName=MERS)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdwx.qlogo.cn/mmopen/vi_32/71tKRib0PibveVjnEa7tPLMaCzoKicFlKSEOzRTGf4wNvDV54kJyNx1ott1D5Xp5gRu7IwUia77oN0YFdffvQMu6Ug/132, createdBy=9e302500146, createdName=ms49895894946433513521, createdTime=Fri Mar 11 08:53:15 CST 2022, time=2022-03-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1246675, encodeId=822612466e5da, content=老年性痴呆,未来还是希望借助神经电生理吧,也许更为有效!, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=neuro.Dr, createdTime=Wed Mar 09 20:53:15 CST 2022, time=2022-03-09, status=1, ipAttribution=)]
    2022-03-15 梅斯助教

    随访

    0

  5. [GetPortalCommentsPageByObjectIdResponse(id=1718131, encodeId=12521e18131cf, content=<a href='/topic/show?id=8f0658433a' target=_blank style='color:#2F92EE;'>#dementia#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5843, encryptionId=8f0658433a, topicName=dementia)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=307e32501717, createdName=linlin2323, createdTime=Fri Oct 14 07:53:15 CST 2022, time=2022-10-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1779829, encodeId=cb431e798290a, content=<a href='/topic/show?id=51b4238909' target=_blank style='color:#2F92EE;'>#alzheimers#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2389, encryptionId=51b4238909, topicName=alzheimers)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=930e243, createdName=dingxiaobo, createdTime=Fri Nov 18 06:53:15 CST 2022, time=2022-11-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1878490, encodeId=d5bb18e849020, content=<a href='/topic/show?id=c157696175' target=_blank style='color:#2F92EE;'>#ERS#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=6961, encryptionId=c157696175, topicName=ERS)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e93e105, createdName=anminleiryan, createdTime=Sat Dec 10 19:53:15 CST 2022, time=2022-12-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1202707, encodeId=ddc01202e078b, content=随访, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210511/ddebdec707734c8390a07bd0c1048717/cc11caf5d607430e9f4ca556fed68ab1.jpg, createdBy=2c4d5497888, createdName=梅斯助教, createdTime=Tue Mar 15 10:51:53 CST 2022, time=2022-03-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1202705, encodeId=b9d61202e05ec, content=<a href='/topic/show?id=1ff01043052c' target=_blank style='color:#2F92EE;'>#谢谢#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=104305, encryptionId=1ff01043052c, topicName=谢谢)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210511/ddebdec707734c8390a07bd0c1048717/cc11caf5d607430e9f4ca556fed68ab1.jpg, createdBy=2c4d5497888, createdName=梅斯助教, createdTime=Tue Mar 15 10:51:09 CST 2022, time=2022-03-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1338551, encodeId=3bce1338551f2, content=<a href='/topic/show?id=767711566a9' target=_blank style='color:#2F92EE;'>#MERS#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11566, encryptionId=767711566a9, topicName=MERS)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdwx.qlogo.cn/mmopen/vi_32/71tKRib0PibveVjnEa7tPLMaCzoKicFlKSEOzRTGf4wNvDV54kJyNx1ott1D5Xp5gRu7IwUia77oN0YFdffvQMu6Ug/132, createdBy=9e302500146, createdName=ms49895894946433513521, createdTime=Fri Mar 11 08:53:15 CST 2022, time=2022-03-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1246675, encodeId=822612466e5da, content=老年性痴呆,未来还是希望借助神经电生理吧,也许更为有效!, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=neuro.Dr, createdTime=Wed Mar 09 20:53:15 CST 2022, time=2022-03-09, status=1, ipAttribution=)]
  6. [GetPortalCommentsPageByObjectIdResponse(id=1718131, encodeId=12521e18131cf, content=<a href='/topic/show?id=8f0658433a' target=_blank style='color:#2F92EE;'>#dementia#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5843, encryptionId=8f0658433a, topicName=dementia)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=307e32501717, createdName=linlin2323, createdTime=Fri Oct 14 07:53:15 CST 2022, time=2022-10-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1779829, encodeId=cb431e798290a, content=<a href='/topic/show?id=51b4238909' target=_blank style='color:#2F92EE;'>#alzheimers#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2389, encryptionId=51b4238909, topicName=alzheimers)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=930e243, createdName=dingxiaobo, createdTime=Fri Nov 18 06:53:15 CST 2022, time=2022-11-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1878490, encodeId=d5bb18e849020, content=<a href='/topic/show?id=c157696175' target=_blank style='color:#2F92EE;'>#ERS#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=6961, encryptionId=c157696175, topicName=ERS)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e93e105, createdName=anminleiryan, createdTime=Sat Dec 10 19:53:15 CST 2022, time=2022-12-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1202707, encodeId=ddc01202e078b, content=随访, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210511/ddebdec707734c8390a07bd0c1048717/cc11caf5d607430e9f4ca556fed68ab1.jpg, createdBy=2c4d5497888, createdName=梅斯助教, createdTime=Tue Mar 15 10:51:53 CST 2022, time=2022-03-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1202705, encodeId=b9d61202e05ec, content=<a href='/topic/show?id=1ff01043052c' target=_blank style='color:#2F92EE;'>#谢谢#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=104305, encryptionId=1ff01043052c, topicName=谢谢)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210511/ddebdec707734c8390a07bd0c1048717/cc11caf5d607430e9f4ca556fed68ab1.jpg, createdBy=2c4d5497888, createdName=梅斯助教, createdTime=Tue Mar 15 10:51:09 CST 2022, time=2022-03-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1338551, encodeId=3bce1338551f2, content=<a href='/topic/show?id=767711566a9' target=_blank style='color:#2F92EE;'>#MERS#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11566, encryptionId=767711566a9, topicName=MERS)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdwx.qlogo.cn/mmopen/vi_32/71tKRib0PibveVjnEa7tPLMaCzoKicFlKSEOzRTGf4wNvDV54kJyNx1ott1D5Xp5gRu7IwUia77oN0YFdffvQMu6Ug/132, createdBy=9e302500146, createdName=ms49895894946433513521, createdTime=Fri Mar 11 08:53:15 CST 2022, time=2022-03-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1246675, encodeId=822612466e5da, content=老年性痴呆,未来还是希望借助神经电生理吧,也许更为有效!, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=neuro.Dr, createdTime=Wed Mar 09 20:53:15 CST 2022, time=2022-03-09, status=1, ipAttribution=)]
  7. [GetPortalCommentsPageByObjectIdResponse(id=1718131, encodeId=12521e18131cf, content=<a href='/topic/show?id=8f0658433a' target=_blank style='color:#2F92EE;'>#dementia#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5843, encryptionId=8f0658433a, topicName=dementia)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=307e32501717, createdName=linlin2323, createdTime=Fri Oct 14 07:53:15 CST 2022, time=2022-10-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1779829, encodeId=cb431e798290a, content=<a href='/topic/show?id=51b4238909' target=_blank style='color:#2F92EE;'>#alzheimers#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2389, encryptionId=51b4238909, topicName=alzheimers)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=930e243, createdName=dingxiaobo, createdTime=Fri Nov 18 06:53:15 CST 2022, time=2022-11-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1878490, encodeId=d5bb18e849020, content=<a href='/topic/show?id=c157696175' target=_blank style='color:#2F92EE;'>#ERS#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=6961, encryptionId=c157696175, topicName=ERS)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e93e105, createdName=anminleiryan, createdTime=Sat Dec 10 19:53:15 CST 2022, time=2022-12-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1202707, encodeId=ddc01202e078b, content=随访, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210511/ddebdec707734c8390a07bd0c1048717/cc11caf5d607430e9f4ca556fed68ab1.jpg, createdBy=2c4d5497888, createdName=梅斯助教, createdTime=Tue Mar 15 10:51:53 CST 2022, time=2022-03-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1202705, encodeId=b9d61202e05ec, content=<a href='/topic/show?id=1ff01043052c' target=_blank style='color:#2F92EE;'>#谢谢#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=104305, encryptionId=1ff01043052c, topicName=谢谢)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210511/ddebdec707734c8390a07bd0c1048717/cc11caf5d607430e9f4ca556fed68ab1.jpg, createdBy=2c4d5497888, createdName=梅斯助教, createdTime=Tue Mar 15 10:51:09 CST 2022, time=2022-03-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1338551, encodeId=3bce1338551f2, content=<a href='/topic/show?id=767711566a9' target=_blank style='color:#2F92EE;'>#MERS#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11566, encryptionId=767711566a9, topicName=MERS)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdwx.qlogo.cn/mmopen/vi_32/71tKRib0PibveVjnEa7tPLMaCzoKicFlKSEOzRTGf4wNvDV54kJyNx1ott1D5Xp5gRu7IwUia77oN0YFdffvQMu6Ug/132, createdBy=9e302500146, createdName=ms49895894946433513521, createdTime=Fri Mar 11 08:53:15 CST 2022, time=2022-03-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1246675, encodeId=822612466e5da, content=老年性痴呆,未来还是希望借助神经电生理吧,也许更为有效!, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=neuro.Dr, createdTime=Wed Mar 09 20:53:15 CST 2022, time=2022-03-09, status=1, ipAttribution=)]
    2022-03-09 neuro.Dr

    老年性痴呆,未来还是希望借助神经电生理吧,也许更为有效!

    0

相关资讯

Lancet:警惕!年轻人焦虑、抑郁等精神问题会增加日后痴呆的风险

如今,被焦虑和抑郁等精神问题困扰的人已越来越多,甚至年轻人已是高危群体。

Neurology:追踪3年,脑卒中后1年期脑白质高信号体积与同时期认知评分密切相关!

脑卒中发生后,波动的脑白质高信号(WMH)显示,1年中而非基线,WMH量与同时期的认知评分密切相关。 纵向协变卒中后认知和日常活动独立性的下降是痴呆诊断的核心,与WMH量的增加有关。

Neurology: 疫情当下,孤独难免常伴:全美大规模队列研究追踪10年,孤独增加罹患痴呆风险!

在这项队列研究中,经过10多年的密切临床痴呆症监测,孤独与痴呆症风险的增加有关,也与ADRD脆弱性的神经认知标志较差有关,这表明了早期致病作用。这些发现可能会对临床和公共卫生发生重要影响。

Alzheimers Dement:血液中的神经退行性蛋白,可提前预测痴呆

GFAP可能是在p-tau181和NfL之前增加的早期AD生物标志物

Alzheimers Dement:种族不同,阿尔兹海默相关指标的长期变化趋势不同

该研究的重要意义在于观察到淀粉样蛋白生物标志物的纵向种族差异。

Alzheimers Dementia:抑郁和长期的认知减退,关系如何?

抑郁症和种族群体之间的关系是复杂的

拓展阅读

BMC MED:代谢综合征、血清尿酸与痴呆症风险之间的关系——一项前瞻性队列研究

本研究提供了强有力的证据,支持 MetS 及其组成部分与痴呆症风险之间的关联。

Eur Urol Focus:抗胆碱能药物、β-3 激动剂或两者联合治疗膀胱过度活动症后,患者患痴呆症的风险如何?

研究人员比较了单独使用 beta-3 激动剂、单独使用抗胆碱能药物或联合上述两种药物治疗 OAB 时,患者患痴呆症的风险情况。结果发现,与单独使用β-3受体激动剂相比,其他组合均会增加新发痴呆症风险。

JAMA Netw Open: 5%-10%的痴呆患者可能存在未确诊的肝硬化,而肝硬化可能是导致整体认知障碍的重要因素

FIB-4 应被视为一种筛查工具,用于检测患有痴呆症的老年退伍军人是否患有肝硬化和潜在的HE,FIB-4 高分者(如>2.67)应考虑进一步评估和治疗。

Nat Aging:这种血液生物标志物可提前15年预测痴呆发病风险

这项研究结果有力地证明了GFAP是预测痴呆症的最佳生物标志物,甚至在痴呆症确诊前15年就可以预测,这对筛查痴呆症高危人群和早期干预具有重要意义。

Neurology:血浆 YKL-40 与核磁共振、脑脊液以及大脑健康和痴呆症认知标记物的关系

较高的血浆YKL-40水平与较低的脑容量、较差的认知能力和痴呆症的发生有关。

中国3亿人缺它,大规模研究发现,补充维生素D,降低痴呆风险

该研究显示,缺乏维生素D与痴呆风险增加相关,补充维生素D与痴呆风险降低相关。缺乏维生素D的人,全因痴呆风险增加25%,阿尔茨海默病风险增加19%,血管性痴呆风险增加24%。