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J Biol Chem：从基因和蛋白层面揭示肝再生的机制

2020-03-18 MedSci原创 MedSci原创

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肝脏的再生能力很可能被编码为肝脏内分子网络的可塑性。通过综合运用表观基因组，转录组和蛋白质组的综合分析，我们在此描述了肝脏再生的分子格局。

肝脏的再生能力很可能被编码为肝脏内分子网络的可塑性。通过综合运用表观基因组，转录组和蛋白质组的综合分析，我们在此描述了肝脏再生的分子格局。

 

结果证明，组蛋白H3 Lys-4在许多基因座的启动子区域被三甲基化，其中只有一部分，包括细胞周期相关基因，在转录环节被上调。在组蛋白甲基化模式和转录组的指导下进行的Cistrome分析确定FOXM1是促进肝脏再生的关键转录因子，在体外使用肝癌细胞系证实了这一点。细胞周期相关基因和Foxm1的启动子区域获得更高水平的三甲基化组蛋白H3 Lys-4，这表明这些关键调控基因的表观遗传学调控决定了肝细胞的静止和再生。对再生肝脏的蛋白质组学定量分析表明，条件蛋白降解还介导了再生特异性蛋白表达。

 

总之，这些信息资源集有利于进一步了解肝脏再生的机制。

 

原始出处：

 

Yoshihiro Sato, Yasutake Katoh, et al., Regulatory signatures of liver regeneration distilled by integrative analysis of mRNA, histone methylation, and proteomics. J Biol Chem. 2017 May 12; 292(19): 8019–8037. doi: 10.1074/jbc.M116.774547

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评论区 (3)
#插入话题
  1. [GetPortalCommentsPageByObjectIdResponse(id=1919023, encodeId=2f441919023d7, content=<a href='/topic/show?id=4f26341994' target=_blank style='color:#2F92EE;'>#Bio#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3419, encryptionId=4f26341994, topicName=Bio)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=12de429, createdName=sunylz, createdTime=Sun Dec 27 04:52:04 CST 2020, time=2020-12-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1767749, encodeId=5d3a1e677498d, content=<a href='/topic/show?id=64f5343e2f' target=_blank style='color:#2F92EE;'>#Biol#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3437, encryptionId=64f5343e2f, topicName=Biol)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=446937890434, createdName=12498ebem31暂无昵称, createdTime=Thu Feb 11 14:52:04 CST 2021, time=2021-02-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1039209, encodeId=3721103920996, content=机制研究离临床仍然有距离，不过与临床结合思考，仍然有帮助的，不能仅仅是纯临床思维，转化思维同样重要, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=肿肿, createdTime=Wed Mar 18 22:52:04 CST 2020, time=2020-03-18, status=1, ipAttribution=)]
    2020-12-27 sunylz

    #Bio#

    0

  2. [GetPortalCommentsPageByObjectIdResponse(id=1919023, encodeId=2f441919023d7, content=<a href='/topic/show?id=4f26341994' target=_blank style='color:#2F92EE;'>#Bio#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3419, encryptionId=4f26341994, topicName=Bio)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=12de429, createdName=sunylz, createdTime=Sun Dec 27 04:52:04 CST 2020, time=2020-12-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1767749, encodeId=5d3a1e677498d, content=<a href='/topic/show?id=64f5343e2f' target=_blank style='color:#2F92EE;'>#Biol#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3437, encryptionId=64f5343e2f, topicName=Biol)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=446937890434, createdName=12498ebem31暂无昵称, createdTime=Thu Feb 11 14:52:04 CST 2021, time=2021-02-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1039209, encodeId=3721103920996, content=机制研究离临床仍然有距离，不过与临床结合思考，仍然有帮助的，不能仅仅是纯临床思维，转化思维同样重要, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=肿肿, createdTime=Wed Mar 18 22:52:04 CST 2020, time=2020-03-18, status=1, ipAttribution=)]
    2021-02-11 12498ebem31暂无昵称

    #Biol#

    0

  3. [GetPortalCommentsPageByObjectIdResponse(id=1919023, encodeId=2f441919023d7, content=<a href='/topic/show?id=4f26341994' target=_blank style='color:#2F92EE;'>#Bio#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3419, encryptionId=4f26341994, topicName=Bio)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=12de429, createdName=sunylz, createdTime=Sun Dec 27 04:52:04 CST 2020, time=2020-12-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1767749, encodeId=5d3a1e677498d, content=<a href='/topic/show?id=64f5343e2f' target=_blank style='color:#2F92EE;'>#Biol#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3437, encryptionId=64f5343e2f, topicName=Biol)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=446937890434, createdName=12498ebem31暂无昵称, createdTime=Thu Feb 11 14:52:04 CST 2021, time=2021-02-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1039209, encodeId=3721103920996, content=机制研究离临床仍然有距离，不过与临床结合思考，仍然有帮助的，不能仅仅是纯临床思维，转化思维同样重要, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=肿肿, createdTime=Wed Mar 18 22:52:04 CST 2020, time=2020-03-18, status=1, ipAttribution=)]
    2020-03-18 肿肿

    机制研究离临床仍然有距离，不过与临床结合思考，仍然有帮助的，不能仅仅是纯临床思维，转化思维同样重要

    0