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科技奖｜华西医院精神疾病研究获奖

2015-04-30 朱方 cmt

脑科学计划磁共振精神疾病
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21世纪是脑科学时代，美欧相继启动了与人类基因组计划相媲美的脑科学计划，其目的是阐明人类大脑工作机制，为揭示重大神经精神疾病的脑机制进而研发新型诊治方法打下理论基础。如何准确无创的测量脑结构和功能成为揭示脑活动机制的核心问题。医学磁共振成像属于新型交叉学科领域，能活体无创评估脑结构、功能等信息，为揭示脑工作机制提供了新的手段和研究方向。龚启勇教授项目组在相关国家重大课题的连续资助下，经过10年的努

21世纪是脑科学时代，美欧相继启动了与人类基因组计划相媲美的脑科学计划，其目的是阐明人类大脑工作机制，为揭示重大神经精神疾病的脑机制进而研发新型诊治方法打下理论基础。如何准确无创的测量脑结构和功能成为揭示脑活动机制的核心问题。医学磁共振成像属于新型交叉学科领域，能活体无创评估脑结构、功能等信息，为揭示脑工作机制提供了新的手段和研究方向。

龚启勇教授项目组在相关国家重大课题的连续资助下，经过10年的努力不断探索功能磁共振新方法，并用于精神分裂症等精神疾病的研究。发现了静息态磁共振BOLD信号低频振幅这一评价脑局部功能的稳定指标。在此基础上联合结构和功能磁共振提出了局部脑结构通过功能网络影响精神分裂症患者临床症状的新观点。同时揭示了患者发病初期微小脑结构和功能异常，阐明了疾病相关行为和临床耐药性发生的潜在神经机理。研究成果不仅为揭示人脑工作机制提供了新的手段和研究方向，也为揭示相关重大神经精神疾病的脑机制打下了理论基础。

上述系列研究成果发表在《美国科学院院报》(IF=9.737)和《美国精神病学杂志》(IF=13.559)等相关领域顶级期刊。被“脑默认网络”的发现者Raichle教授(美国科学院院士)在Nature系列杂志多次正面引用。首次提出的疾病-脑机制模型得到《美国精神病学杂志》编辑的重点述评。基于本项目的成果，项目团队入选教育部创新团队。第一完成人多次受邀前往哈佛、斯坦福和耶鲁等大学讲学，并为第23届国际医学磁共振学会(ISMRM)大会作NIBIB New Horizons Lecture冠名荣誉主题演讲(8000名ISMRM会员中，每年有一位学者入选)，体现了本项目团队的国际影响。

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    2015-12-25 amy0550

    #疾病研究#

    0

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    2015-12-05 12498cf9m35(暂无昵称)

    #西医院#

    0

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    2015-07-07 zhouanxiu

    厉害

    0

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    2015-06-02 若水135

    #获奖#

    0

  5. [GetPortalCommentsPageByObjectIdResponse(id=2070389, encodeId=8a1d20e038929, content=<a href='/topic/show?id=f30de0713e1' target=_blank style='color:#2F92EE;'>#疾病研究#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=48, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=70713, encryptionId=f30de0713e1, topicName=疾病研究)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=010d202, createdName=amy0550, createdTime=Fri Dec 25 23:34:00 CST 2015, time=2015-12-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1974080, encodeId=c57119e40802e, content=<a href='/topic/show?id=4d9d904e092' target=_blank style='color:#2F92EE;'>#西医院#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=90470, encryptionId=4d9d904e092, topicName=西医院)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d47b2500175, createdName=12498cf9m35(暂无昵称), createdTime=Sat Dec 05 02:34:00 CST 2015, time=2015-12-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=30950, encodeId=5cfd3095048, content=厉害, beContent=null, objectType=article, channel=null, level=null, likeNumber=147, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3yz0JbjHQ7nicJU7lHMOu0Itf3Zv3VBzEvK3k4AFPBXhiaxIRNGVI33GicoRXQEjkaasjdlWKwZuwcyhDP9Jibqt5ct/0, createdBy=f1281613275, createdName=zhouanxiu, createdTime=Tue Jul 07 02:42:00 CST 2015, time=2015-07-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1763942, encodeId=65471e639427b, content=<a href='/topic/show?id=ecf88800939' target=_blank style='color:#2F92EE;'>#获奖#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=88009, encryptionId=ecf88800939, topicName=获奖)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=9d5937606588, createdName=若水135, createdTime=Tue Jun 02 22:34:00 CST 2015, time=2015-06-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1721444, encodeId=d4821e214448a, content=<a href='/topic/show?id=c7c5e4947cb' target=_blank style='color:#2F92EE;'>#科技奖#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=74947, encryptionId=c7c5e4947cb, topicName=科技奖)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=423733003907, createdName=w363522460, createdTime=Sun Nov 15 22:34:00 CST 2015, time=2015-11-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1445828, encodeId=88ed1445828ab, content=<a href='/topic/show?id=949e3593330' target=_blank style='color:#2F92EE;'>#华西#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=35933, encryptionId=949e3593330, topicName=华西)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/nE4GrbxL2qh8HCfQ9Aic863Ks6MQVCgNnxZib6aVhV679l2JX0YVwulK1GZ3QaOicPXvFNvZHicPicQ95qx3OH9evVw/132, createdBy=cbc15186945, createdName=fengyqf, createdTime=Sat May 02 00:34:00 CST 2015, time=2015-05-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=22303, encodeId=d6ef22303ba, content=可喜！, beContent=null, objectType=article, channel=null, level=null, likeNumber=116, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=121e1622385, createdName=chenhui888, createdTime=Thu Apr 30 09:50:00 CST 2015, time=2015-04-30, status=1, ipAttribution=)]
    2015-11-15 w363522460

    #科技奖#

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=2070389, encodeId=8a1d20e038929, content=<a href='/topic/show?id=f30de0713e1' target=_blank style='color:#2F92EE;'>#疾病研究#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=48, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=70713, encryptionId=f30de0713e1, topicName=疾病研究)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=010d202, createdName=amy0550, createdTime=Fri Dec 25 23:34:00 CST 2015, time=2015-12-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1974080, encodeId=c57119e40802e, content=<a href='/topic/show?id=4d9d904e092' target=_blank style='color:#2F92EE;'>#西医院#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=90470, encryptionId=4d9d904e092, topicName=西医院)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d47b2500175, createdName=12498cf9m35(暂无昵称), createdTime=Sat Dec 05 02:34:00 CST 2015, time=2015-12-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=30950, encodeId=5cfd3095048, content=厉害, beContent=null, objectType=article, channel=null, level=null, likeNumber=147, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3yz0JbjHQ7nicJU7lHMOu0Itf3Zv3VBzEvK3k4AFPBXhiaxIRNGVI33GicoRXQEjkaasjdlWKwZuwcyhDP9Jibqt5ct/0, createdBy=f1281613275, createdName=zhouanxiu, createdTime=Tue Jul 07 02:42:00 CST 2015, time=2015-07-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1763942, encodeId=65471e639427b, content=<a href='/topic/show?id=ecf88800939' target=_blank style='color:#2F92EE;'>#获奖#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=88009, encryptionId=ecf88800939, topicName=获奖)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=9d5937606588, createdName=若水135, createdTime=Tue Jun 02 22:34:00 CST 2015, time=2015-06-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1721444, encodeId=d4821e214448a, content=<a href='/topic/show?id=c7c5e4947cb' target=_blank style='color:#2F92EE;'>#科技奖#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=74947, encryptionId=c7c5e4947cb, topicName=科技奖)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=423733003907, createdName=w363522460, createdTime=Sun Nov 15 22:34:00 CST 2015, time=2015-11-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1445828, encodeId=88ed1445828ab, content=<a href='/topic/show?id=949e3593330' target=_blank style='color:#2F92EE;'>#华西#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=35933, encryptionId=949e3593330, topicName=华西)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/nE4GrbxL2qh8HCfQ9Aic863Ks6MQVCgNnxZib6aVhV679l2JX0YVwulK1GZ3QaOicPXvFNvZHicPicQ95qx3OH9evVw/132, createdBy=cbc15186945, createdName=fengyqf, createdTime=Sat May 02 00:34:00 CST 2015, time=2015-05-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=22303, encodeId=d6ef22303ba, content=可喜！, beContent=null, objectType=article, channel=null, level=null, likeNumber=116, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=121e1622385, createdName=chenhui888, createdTime=Thu Apr 30 09:50:00 CST 2015, time=2015-04-30, status=1, ipAttribution=)]
    2015-05-02 fengyqf

    #华西#

    0

  7. [GetPortalCommentsPageByObjectIdResponse(id=2070389, encodeId=8a1d20e038929, content=<a href='/topic/show?id=f30de0713e1' target=_blank style='color:#2F92EE;'>#疾病研究#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=48, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=70713, encryptionId=f30de0713e1, topicName=疾病研究)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=010d202, createdName=amy0550, createdTime=Fri Dec 25 23:34:00 CST 2015, time=2015-12-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1974080, encodeId=c57119e40802e, content=<a href='/topic/show?id=4d9d904e092' target=_blank style='color:#2F92EE;'>#西医院#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=90470, encryptionId=4d9d904e092, topicName=西医院)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d47b2500175, createdName=12498cf9m35(暂无昵称), createdTime=Sat Dec 05 02:34:00 CST 2015, time=2015-12-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=30950, encodeId=5cfd3095048, content=厉害, beContent=null, objectType=article, channel=null, level=null, likeNumber=147, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3yz0JbjHQ7nicJU7lHMOu0Itf3Zv3VBzEvK3k4AFPBXhiaxIRNGVI33GicoRXQEjkaasjdlWKwZuwcyhDP9Jibqt5ct/0, createdBy=f1281613275, createdName=zhouanxiu, createdTime=Tue Jul 07 02:42:00 CST 2015, time=2015-07-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1763942, encodeId=65471e639427b, content=<a href='/topic/show?id=ecf88800939' target=_blank style='color:#2F92EE;'>#获奖#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=88009, encryptionId=ecf88800939, topicName=获奖)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=9d5937606588, createdName=若水135, createdTime=Tue Jun 02 22:34:00 CST 2015, time=2015-06-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1721444, encodeId=d4821e214448a, content=<a href='/topic/show?id=c7c5e4947cb' target=_blank style='color:#2F92EE;'>#科技奖#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=74947, encryptionId=c7c5e4947cb, topicName=科技奖)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=423733003907, createdName=w363522460, createdTime=Sun Nov 15 22:34:00 CST 2015, time=2015-11-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1445828, encodeId=88ed1445828ab, content=<a href='/topic/show?id=949e3593330' target=_blank style='color:#2F92EE;'>#华西#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=35933, encryptionId=949e3593330, topicName=华西)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/nE4GrbxL2qh8HCfQ9Aic863Ks6MQVCgNnxZib6aVhV679l2JX0YVwulK1GZ3QaOicPXvFNvZHicPicQ95qx3OH9evVw/132, createdBy=cbc15186945, createdName=fengyqf, createdTime=Sat May 02 00:34:00 CST 2015, time=2015-05-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=22303, encodeId=d6ef22303ba, content=可喜！, beContent=null, objectType=article, channel=null, level=null, likeNumber=116, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=121e1622385, createdName=chenhui888, createdTime=Thu Apr 30 09:50:00 CST 2015, time=2015-04-30, status=1, ipAttribution=)]
    2015-04-30 chenhui888

    可喜！

    0