湘雅二院学者研究显示,HDL-C水平与主动脉夹层院内死亡呈负相关

2018-02-27 卢芳 中国循环杂志

主动脉夹层是有名的凶险,中南大学湘雅二医院柴湘平、李文等进行的研究显示,这类患者存在明显的血脂代谢异常,而且那些死里逃生者的血清高密度脂蛋白胆固醇(HDL-C)水平要比死亡者明显要高。

主动脉夹层是有名的凶险,中南大学湘雅二医院柴湘平、李文等进行的研究显示,这类患者存在明显的血脂代谢异常,而且那些死里逃生者的血清高密度脂蛋白胆固醇(HDL-C)水平要比死亡者明显要高。

研究者发现,与单纯高血压患者相比,主动脉夹层患者的总胆固醇(TC)水平明显较高、HDL-C水平则显着较低。也就是说,主动脉夹层患者血脂代谢紊乱更明显。

研究者指出,TC增高可能与加重主动脉血管内皮舒张功能受损进而促成主动脉夹层形成有关;而低水平HDL-C或与加重主动脉粥样硬化有关。

不过也有研究显示,低水平TC与A型主动脉夹层患者高死亡率相关,研究者表示具体原因还有待进一步研究。

此外研究还显示,A型(胸主动脉夹层)主动脉夹层患者HDL-C/TC比值明显低于B型(腹主动脉夹层)患者,提示前者HDL-C水平与TC水平比例失调严重,造成血脂代谢更加紊乱。

研究者还比较了生死患者的血脂情况,结果不仅发现死者血清HDL-C 水平显着低于死者,进一步分析还显示,HDL-C水平与主动脉夹层患者的院内死亡呈中度负相关。

研究者推测,HDL-C水平低死亡风险高,或与HDL-C水平较低不利于调节细胞外基质重建、细胞分化及增殖有关。

研究者表示,调脂治疗可能成为治疗主动脉疾病的新靶点。

该研究回顾性分析了153例主动脉夹层患者血脂水平的改变,其中包括80例A 型主动脉夹层患者和73例B型主动脉夹层患者,同时选取50例单纯高血压患者作为对照。

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    2018-03-01 ZGMFX24A
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  5. [GetPortalCommentsPageByObjectIdResponse(id=1635239, encodeId=fc3016352395d, content=<a href='/topic/show?id=bb41983049e' target=_blank style='color:#2F92EE;'>#院内死亡#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=98304, encryptionId=bb41983049e, topicName=院内死亡)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=78f122436081, createdName=yuhaisheng_ibp_32061718, createdTime=Fri Dec 21 13:41:00 CST 2018, time=2018-12-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1316431, encodeId=582e13164319f, content=<a href='/topic/show?id=73f386080a' target=_blank style='color:#2F92EE;'>#HDL#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=22, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=8608, encryptionId=73f386080a, topicName=HDL)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7fb6449, createdName=ZGMFX24A, createdTime=Thu Mar 01 11:41:00 CST 2018, time=2018-03-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1415281, encodeId=39f014152816f, content=<a href='/topic/show?id=04812314540' target=_blank style='color:#2F92EE;'>#主动脉#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=23145, encryptionId=04812314540, topicName=主动脉)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=77603112682, createdName=circumcision, createdTime=Thu Mar 01 11:41:00 CST 2018, time=2018-03-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1480825, encodeId=c18a1480825b1, content=<a href='/topic/show?id=edd28609dd' target=_blank style='color:#2F92EE;'>#HDL-C#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=8609, encryptionId=edd28609dd, topicName=HDL-C)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b0a97689161, createdName=ms920641618706883, createdTime=Thu Mar 01 11:41:00 CST 2018, time=2018-03-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1519566, encodeId=8078151956626, content=<a href='/topic/show?id=b63a3323558' target=_blank style='color:#2F92EE;'>#动脉夹层#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=33235, encryptionId=b63a3323558, topicName=动脉夹层)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ae5711287462, createdName=mhzhuang@stu.e, createdTime=Thu Mar 01 11:41:00 CST 2018, time=2018-03-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1573233, encodeId=24ab15e3233c2, content=<a href='/topic/show?id=34009226531' target=_blank style='color:#2F92EE;'>#负相关#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=92265, encryptionId=34009226531, topicName=负相关)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=2c2115837741, createdName=hmwwww, createdTime=Thu Mar 01 11:41:00 CST 2018, time=2018-03-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1595796, encodeId=96301595e9609, content=<a href='/topic/show?id=d39e6642328' target=_blank style='color:#2F92EE;'>#湘雅#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=66423, encryptionId=d39e6642328, topicName=湘雅)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=853618305022, createdName=xiaoshitou, createdTime=Thu Mar 01 11:41:00 CST 2018, time=2018-03-01, status=1, ipAttribution=)]
  6. [GetPortalCommentsPageByObjectIdResponse(id=1635239, encodeId=fc3016352395d, content=<a href='/topic/show?id=bb41983049e' target=_blank style='color:#2F92EE;'>#院内死亡#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=98304, encryptionId=bb41983049e, topicName=院内死亡)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=78f122436081, createdName=yuhaisheng_ibp_32061718, createdTime=Fri Dec 21 13:41:00 CST 2018, time=2018-12-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1316431, encodeId=582e13164319f, content=<a href='/topic/show?id=73f386080a' target=_blank style='color:#2F92EE;'>#HDL#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=22, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=8608, encryptionId=73f386080a, topicName=HDL)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7fb6449, createdName=ZGMFX24A, createdTime=Thu Mar 01 11:41:00 CST 2018, time=2018-03-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1415281, encodeId=39f014152816f, content=<a href='/topic/show?id=04812314540' target=_blank style='color:#2F92EE;'>#主动脉#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=23145, encryptionId=04812314540, topicName=主动脉)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=77603112682, createdName=circumcision, createdTime=Thu Mar 01 11:41:00 CST 2018, time=2018-03-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1480825, encodeId=c18a1480825b1, content=<a href='/topic/show?id=edd28609dd' target=_blank style='color:#2F92EE;'>#HDL-C#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=8609, encryptionId=edd28609dd, topicName=HDL-C)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b0a97689161, createdName=ms920641618706883, createdTime=Thu Mar 01 11:41:00 CST 2018, time=2018-03-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1519566, encodeId=8078151956626, content=<a href='/topic/show?id=b63a3323558' target=_blank style='color:#2F92EE;'>#动脉夹层#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=33235, encryptionId=b63a3323558, topicName=动脉夹层)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ae5711287462, createdName=mhzhuang@stu.e, createdTime=Thu Mar 01 11:41:00 CST 2018, time=2018-03-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1573233, encodeId=24ab15e3233c2, content=<a href='/topic/show?id=34009226531' target=_blank style='color:#2F92EE;'>#负相关#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=92265, encryptionId=34009226531, topicName=负相关)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=2c2115837741, createdName=hmwwww, createdTime=Thu Mar 01 11:41:00 CST 2018, time=2018-03-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1595796, encodeId=96301595e9609, content=<a href='/topic/show?id=d39e6642328' target=_blank style='color:#2F92EE;'>#湘雅#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=66423, encryptionId=d39e6642328, topicName=湘雅)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=853618305022, createdName=xiaoshitou, createdTime=Thu Mar 01 11:41:00 CST 2018, time=2018-03-01, status=1, ipAttribution=)]
    2018-03-01 hmwwww
  7. [GetPortalCommentsPageByObjectIdResponse(id=1635239, encodeId=fc3016352395d, content=<a href='/topic/show?id=bb41983049e' target=_blank style='color:#2F92EE;'>#院内死亡#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=98304, encryptionId=bb41983049e, topicName=院内死亡)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=78f122436081, createdName=yuhaisheng_ibp_32061718, createdTime=Fri Dec 21 13:41:00 CST 2018, time=2018-12-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1316431, encodeId=582e13164319f, content=<a href='/topic/show?id=73f386080a' target=_blank style='color:#2F92EE;'>#HDL#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=22, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=8608, encryptionId=73f386080a, topicName=HDL)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7fb6449, createdName=ZGMFX24A, createdTime=Thu Mar 01 11:41:00 CST 2018, time=2018-03-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1415281, encodeId=39f014152816f, content=<a href='/topic/show?id=04812314540' target=_blank style='color:#2F92EE;'>#主动脉#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=23145, encryptionId=04812314540, topicName=主动脉)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=77603112682, createdName=circumcision, createdTime=Thu Mar 01 11:41:00 CST 2018, time=2018-03-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1480825, encodeId=c18a1480825b1, content=<a href='/topic/show?id=edd28609dd' target=_blank style='color:#2F92EE;'>#HDL-C#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=8609, encryptionId=edd28609dd, topicName=HDL-C)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b0a97689161, createdName=ms920641618706883, createdTime=Thu Mar 01 11:41:00 CST 2018, time=2018-03-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1519566, encodeId=8078151956626, content=<a href='/topic/show?id=b63a3323558' target=_blank style='color:#2F92EE;'>#动脉夹层#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=33235, encryptionId=b63a3323558, topicName=动脉夹层)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ae5711287462, createdName=mhzhuang@stu.e, createdTime=Thu Mar 01 11:41:00 CST 2018, time=2018-03-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1573233, encodeId=24ab15e3233c2, content=<a href='/topic/show?id=34009226531' target=_blank style='color:#2F92EE;'>#负相关#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=92265, encryptionId=34009226531, topicName=负相关)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=2c2115837741, createdName=hmwwww, createdTime=Thu Mar 01 11:41:00 CST 2018, time=2018-03-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1595796, encodeId=96301595e9609, content=<a href='/topic/show?id=d39e6642328' target=_blank style='color:#2F92EE;'>#湘雅#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=66423, encryptionId=d39e6642328, topicName=湘雅)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=853618305022, createdName=xiaoshitou, createdTime=Thu Mar 01 11:41:00 CST 2018, time=2018-03-01, status=1, ipAttribution=)]
    2018-03-01 xiaoshitou